Publications by authors named "Qi-Sheng Xia"

Although photodynamic therapy (PDT) has been extensively studied as an established modality of cancer treatment, it still suffers from a few clinical limitations, such as skin phototoxicity and tumor hypoxia. To circumvent these hurdles, hollow silica mesoporous nanoparticles (HMSNs) loaded with photosensitizers were employed as the nanoplatform to construct multifunctional nanoparticles (NPs). Specifically, an ultra-uniform polydopamine (PDA) shell was highly controlled grown around HMSNs by photogenerated outwards-diffused O, followed by conjugation of folic acid-poly(ethylene glycol) and chelation of Fe ions.

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Article Synopsis
  • Current diagnostic markers for gastric neuroendocrine neoplasms (g-NENs) are lacking, but previous studies indicate that miRNA-202-3p is overexpressed in tumor tissues of type 1 g-NEN patients.
  • A study with 27 type 1 g-NEN patients and 27 matched controls measured miRNA-202-3p levels in serum, revealing significantly higher levels in patients (3.84 × 10 copies/nl) compared to controls (0.635 × 10 copies/nl).
  • The findings suggest that miRNA-202-3p could serve as a promising biomarker for type 1 g-NEN, with a sensitivity of 88.
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Objective: To investigate the effect of inhibiting the expression of human suppressor of morphogenesis in genitalia-1 (hSMG-1) on chemosensitivity in human lung cancer H1299 cells.

Methods: Specialized small interference RNAs (siRNAs) of hSMG-1 were transfected into H1299 cells. The knockdown effect was evaluated by quantitative real-time reverse transcription-polymerase chain reaction (RT-PCR) and immunofluorescence.

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Current treatment modalities for melanoma do not offer satisfactory efficacy. We have developed a new, minimally invasive hyperthermia technology based on radio-frequency hyperthermia. Herein, we investigated the feasibility of using a nickel-copper thermoseed for inductive hyperthermia at a relatively high temperature (46-55 ˚C).

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Article Synopsis
  • The study investigates how anticancer agents affect the expression of the microRNA-155 precursor, BIC, which is often overexpressed in tumors.
  • Using various chemical inhibitors and RNA interference, the researchers explored different signaling pathways that may influence BIC expression.
  • They found that the anti-cancer drug gemcitabine increases BIC levels in pancreatic cancer cells and that the PI3K pathway, specifically involving SMG-1, is crucial for this process.
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The Family with sequence similarity 107 (FAM107) possesses an N-terminal domain of unknown function (DUF1151) that is highly conserved beyond species. In human, FAM107A termed TU3A/DRR1 has been reported as a candidate tumor suppressor gene which expression is downregulated in several types of cancer, however no studies have investigated the other family protein, FAM107B. In the present study, we designated FAM107B as heat shock-inducible tumor small protein (HITS) and studied its expression and functional properties in cancer.

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Objective: To investigate the effect of anti-cancer drugs on the expression of B-cell integration cluster (BIC) RNA/miRNA-155 in human pancreatic cancer PANC-1 cells.

Methods: PANC-1 cells were treated with different concentrations of anti-cancer drugs. Total RNA of the treated cells were harvested and the expression levels of BIC RNA and mature miR-155 were quantified by using Taqman FAM/MGB probes on a real-time PCR system.

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The magnetite (Fe(3)O(4)) nanoparticles were prepared by coprecipitation of Fe(3+) and Fe(2+) with an aqueous NaOH solution. The Fe(3)O(4)/polyaniline (PANI) magnetic composite nanoparticles with a core-shell structure with a diameter of 30-50 nm were prepared via an in situ polymerization of aniline in an aqueous solution containing the Fe(3)O(4) magnetic fluid. The inductive heat property of Fe(3)O(4)/PANI composite nanoparticles in an alternating current (ac) magnetic field was investigated.

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Background & Objective: Ferromagnet has thermal effect in alternating magnetic field (AMF). Magnetically mediating hyperthermia is to localize magnetic substance within tumor tissue under AMF to promote the targeting ability and heat distribution of hyperthermia. This study was to develop a new method of showing the thermal effect of iron oxide Fe3O4 nanoparticles in AMF in vitro.

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