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Publications by authors named "Qi-Qi Ren"

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Inhibition of ATP1V6G3 prompts hepatic stellate cell senescence with reducing ECM by activating Notch1 pathway to alleviate hepatic fibrosis.
Xiao-Pei Xue Yu Sheng Qi-Qi Ren Shi-Meng Xu Min Li

Tissue Cell

December 2024

Article Synopsis
  • - Liver fibrosis happens due to an overactive healing response, primarily driven by activated hepatic stellate cells (aHSCs) that accumulate extracellular matrix (ECM) in the liver.
  • - Inducing senescence (a growth halt) in aHSCs can help break down ECM and reduce fibrosis, with ATP6V1G3 being identified as a key factor in this process that needs further exploration.
  • - Preliminary findings suggest that inhibiting ATP6V1G3 can trigger senescence in aHSCs, and blocking the Notch1 pathway can reverse this effect, highlighting ATP6V1G3 as a potential target for treating liver fibrosis.
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