Chem Commun (Camb)
November 2020
A visible light promoted deaminative strategy for the difluoroalkylation reaction utilizing pyridinium-activated aliphatic primary amines and difluoroenoxysilane as substrates has been developed. This protocol is characteriazed by its mild reaction conditions and broad substrate scope, which converted a diverse array of amine-containing molecules to the alkyl-CFCOPh products. Moreover, the resulting products can be easily transformed into a vast array of structurally novel and interesting difluoro-containing moieties, therefore providing a facile route for applications in medicinal chemistry and the life sciences.
View Article and Find Full Text PDFA polarisation-division-multiplexing (PDM)-based four-level pulse amplitude modulation (PAM4) fibre-free-space optical (FSO) convergent system with optical band-pass filters (OBPFs) for polarisation de-multiplexing is feasibly demonstrated for the first time. In a PDM scenario with PAM4 modulation, the transmission capacity of fibre-FSO convergent systems is enhanced four times with an aggregate channel capacity of 128 Gb/s (64 Gb/s PAM4/polarisation × 2 polarisations). With an OBPF, polarisation-tracking free de-multiplexing is attained by eliminating other optical carrier with orthogonal polarisation.
View Article and Find Full Text PDFA polarization-division-multiplexing (PDM)-based bi-directional fibre-free-space optical (FSO) integration with two reflective semiconductor optical amplifiers (RSOAs) scheme to efficiently wipe off the modulated data for upstream modulation is proposed and successfully demonstrated. For downstream modulation, a high-speed 128 Gb/s vestigial sideband (VSB)-four-level pulse amplitude modulation (PAM4) fibre-FSO integration is feasibly established. The transmission capacity is increased up to four times through PDM operation and VSB-PAM4 modulation.
View Article and Find Full Text PDFA micropipette technique was used to investigate the effects of four synthetic peptides, YIGSR, CDPGYIGSR, RGDS and GRGDTP, on the adhesion of hepatocellular carcinoma (HCC) cells onto type IV collagen/laminin/fibronectin coated surfaces. Adhesion of HCC cells to laminin was found to be YIGSR- or CDPGYIGSR-dependent while that to fibronectin and type IV collagen was RGDS- or GRGDTP-dependent. The reduction in adhesion strengths of HCC cells was slight to moderate (up to 55%), and was dependent on the peptide concentration.
View Article and Find Full Text PDFSheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai)
November 2002
Using a cyclic strain unit, the proliferation and reorganization of alpha(5), beta(1 ) integrins in human pulmonary epithelial A549 cells that underwent mechanical strain were studied. Flow cytometry revealed that cellular proliferative index reduced significantly after cells were subjected to 15% elongation at frequency 20 cycles/min or 40 cycles/min for 48 h. Confocal microscopy revealed that alpha(5), beta(1 ) integrins in human pulmonary epithelial A549 cells transferred from the apic al layer to the basal layer and created adhesion plaques after 24 h exposure to 15% elongation at frequency 40 cycles/min.
View Article and Find Full Text PDF