Synthesis and biological evaluation of novel tanshinone IIA derivatives for treating pain.

Due to ineffectiveness and side effects of existing analgesics, chronic pain has become one of the most complex and difficult problems in the clinic. Monoacylglycerol lipase (MAGL) is an essential hydrolase in the endocannabinoid system and has been identified as a potential target for the treatment of pain. In the present study, we designed and synthesized twelve tanshinone IIA analogs and screened their activity against MAGL.

Dual-wavelength Nd:YAG laser operation at 1319 and 1338 nm by direct pumping at 885 nm.

This paper presents a continuous wave and a Q-switched Nd:YAG laser pumped by diode laser at 885 nm. The maximum output power of the CW laser is 8.28 W with an absorbed slope efficiency of 35.

[Application of wavelet transform to the infrared diffusion reflectance spectrum of rocks].

The infrared diffuse reflectance spectra of hydrocarbon source rocks with different particle sizes were measured. The result indicated that the absorbency of the raw spectrum decreased with the reduction of particle size, but the relationship turned to be reverse after we pretreated the original spectra by using wavelet transform to eliminate the background and calibrate the baseline drift, both of which were caused by scattering. The reversed relations showed that the spectral lines were influenced deeply by the scattering of the samples.

[Surface-enhanced Raman spectra of oxidation damnification of fetal bovine serum by ozone].

Fetal bovine serum was treated by ozone for 1 hour and 3 hours before getting its surface-enhanced Raman spectra from 200 to 1 800 cm(-1). Treated with ozone for 1 hour, it shows a significant decrease in band intensity. Treated with ozone for 3 hours, the band intensity has a further decrease but not so obviously, which means that oxidation of ozone is short lived.

[The orthogonal polynomial regression method of multi-wavelength radiation thermometry].

For the problem of multi-wavelength radiation thermometry, the traditional data processing methods are the least squares techniques, the multiple linear regression fitting, and the stepwise regression fitting. There are some shortages in these methods, resulting in a certain error between the fitting result and the true temperature of the object surface. A new data processing method of multi-wavelength radiation thermometry--the orthogonal polynomial regression method was brought forward in this article on the base of variable emissivity.