Endoplasmic Reticulum and Its Significance in Periodontal Disease.

The endoplasmic reticulum has emerged as a modulator that is essential for cellular homeostasis and human health. It is an extensive membranous organelle that acts as a hub for the physiological and pathological processes. In recent years, it has become a topic of interest in studies on the relationship between endoplasmic reticulum homeostasis and system diseases.

Mechanosensing by Gli1 cells contributes to the orthodontic force-induced bone remodelling.

Objectives: Gli1 cells have received extensive attention in tissue homeostasis and injury mobilization. The aim of this study was to investigate whether Gli1 cells respond to force and contribute to bone remodelling.

Materials And Methods: We established orthodontic tooth movement (OTM) model to assess the bone response for mechanical force.