MiR-17-5p inhibits cerebral hypoxia/reoxygenationinjury by targeting PTEN through regulation of PI3K/AKT/mTOR signaling pathway.

Objective: To investigate the role and mechanism of miR-17-5p in cerebral hypoxia/reoxygenation (H/R)-induced apoptosis.

Methods: The present study used human brain microvascular endothelial cells (HBMVECs) to establish cerebral H/R model. MTT was used to measure the cell viability.

Extract of L. Seeds Ameliorates Hypertension in Spontaneously Hypertensive Rats by Inhibition of Angiotensin Converting Enzyme.

L. seeds is a common folk medicine with a long history of medical use in China because of its antipyretic, diuretic, and expectorant properties. It has been applied to treat hypertension clinically due to its diuresis, however, its efficacy and mechanisms on anti-hypertension has not been reported yet to our knowledge.

Bioactive diterpenoids and flavonoids from the aerial parts of Scoparia dulcis.

Six new diterpenoids, 4-epi-7α-O-acetylscoparic acid A (1), 7α-hydroxyscopadiol (2), 7α-O-acetyl-8,17β-epoxyscoparic acid A (3), neo-dulcinol (4), dulcinodal-13-one (5), and 4-epi-7α-hydroxydulcinodal-13-one (6), and a new flavonoid, dillenetin 3-O-(6″-O-p-coumaroyl)-β-D-glucopyranoside (10), along with 12 known compounds, were isolated from the aerial parts of Scoparia dulcis. The 7S absolute configuration of the new diterpenoids 1-4 and 6 was deduced by comparing their NOESY spectra with that of a known compound, (7S)-4-epi-7-hydroxyscoparic acid A (7), which was determined by the modified Mosher's method. The flavonoids scutellarein (11), hispidulin (12), apigenin (15), and luteolin (16) and the terpenoids 4-epi-scopadulcic acid B (9) and betulinic acid (19) showed more potent α-glucosidase inhibitory effects (with IC50 values in the range 13.

Apolipoprotein H gene polymorphisms and risk of primary cerebral hemorrhage in a Chinese population.

Background And Purpose: Apolipoprotein H (ApoH) has been implicated in several physiologic pathways including lipid metabolism, coagulation and the production of hypertension, which are related to the pathogenesis of primary cerebral hemorrhage (PICH). The gene coding for ApoH is polymorphic, with the occurrence of several common alleles in the general population. This genetically determined variation can effect lipid metabolism and the production of hypertension.

[The relationship of apolipoprotein H gene polymorphism with stroke].

Objective: To study the association between apolipoprotein H (apoH) gene polymorphism and cerebral apoplexy among the Hans in Changsha, Hunan Province.

Methods: Polymorphisms in exon 3 of apoH gene was determined by PCR-single strand conformation polymorphism (PCR-SSCP) analysis and DNA sequencing among 260 patients with stroke of Han nationality in Changsha, including 130 cerebral hemorrhage (CH) patients, of which 50 were with a family history of CH, and 79 with hypertension and 51 without hypertension, and 130 cerebral infarction (CI) patients, of which 50 were with a family history of CI, and 66 with hypertension and 64 without hypertension; 20 members of stroke pedigrees, and 100 healthy controls.

Results: G341A (Ser88Asn) polymorphism in exon 3 of apoH gene was found in Changsha Hans.