To evaluate the effects of Hydroxypropyl methylcellulose acetate succinate(HPMCAS MF) on absorption of silybin(SLB) from supersaturable self-nanoemulsifying drug delivery system which was pre-prepared at the early stage experiment. The cell toxicity of self-emulsifying preparation was evaluated by the MTT method, and the in vitro membrane permeability and absorption promoting effect of the self-emulsifying preparation were evaluated by establishing a Caco-2 cell monolayer model. The in vivo and in vitro supersaturation correlation was evaluated via the blood concentration of SLB.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
February 2021
Zhongguo Zhong Yao Za Zhi
August 2020
In order to improve the supersaturation and maintenance time of drug dispersion in curcumin self-nanoemulsion(CUR-SNEDDS), precipitation inhibitors(PPIs) were introduced to prepare curcumin supersaturated self-emulsion(CUR-SSNEDDS). The composition of CUR-SNEDDS prescriptions was selected through the solubility test, the compatibility of oil phase and surfactant, the investigation of the emulsifying ability of the surfactant and the drawing of the pseudo-ternary phase diagram. Analytic hierarchy process was used in combination with central composite design-response surface method to optimize the prescription.
View Article and Find Full Text PDFA non-exclusion paternity case with a mismatch in the autosomal short tandem repeats (STR) locus FGA is reported. The genotypes of the suspected father, the mother and the questioned child in FGA locus were 18/25, 20/26 and 20/22, respectively. Examination of 38 autosomal STR loci revealed no mismatches, and the paternity index is up to 1.
View Article and Find Full Text PDF