Publications by authors named "Qi-Lei Chen"

Article Synopsis
  • Cancer is a leading global cause of death, and a major obstacle in treatment is multidrug resistance (MDR) in tumors.
  • Recent research has shown that compounds derived from natural products, like flavonoids and alkaloids, can potentially reverse MDR.
  • This review discusses past successes and current advancements in using natural products as treatments, aiming to contribute insights into combating MDR in cancer therapy.
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During the survey on freshwater hyphomycetes in Guangxi, Guizhou and Hainan Provinces, China, five fresh collections were encountered. Based on their morphology, these five isolates were identified as belonging to , , , and . Multi-gene phylogenetic analyses were performed for each genus, which resulted in the identification of five new species, namely , , , , and .

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Cancer is a common and intractable disease that seriously affects quality of life of patients and imposes heavy economic burden on families and the entire society. Current medications and intervention strategies for cancer have respective shortcomings. In recent years, it has been increasingly spotlighted that chemokines and their receptors play vital roles in the pathophysiology of cancer.

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Article Synopsis
  • Morindae Officinalis Radix (MOR) is a traditional supplement in southeastern China used for bone health and reproductive care, typically derived from 3-4 year old roots, with the xylem sometimes removed.
  • This study employed metabolomics and glycomics techniques to analyze the chemical properties of MOR at different ages (1-7 years) and from different tissues (xylem and cortex).
  • Findings revealed that the highest concentration of beneficial bioactive components occurs at 3-4 years, while the xylem has more potentially harmful substances and fewer beneficial components than the cortex, supporting the current practices of using younger roots without the xylem.
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This study establishes a new combinatorial approach for histochemical analysis of polysaccharides in herbal medicines using laser microdissection followed by high performance gel permeation chromatography coupled with charged aerosol detector and ultra-performance liquid chromatography hyphenated with triple quadrupole mass spectrometry. Ginseng was employed as a study model. Tissue-specific qualitative and quantitative characterization of ginseng polysaccharides was performed by determining their molar masses and monosaccharide compositions in three macro-dissected parts (rhizome, main and branched roots) and five micro-dissected tissues (cork, cortex, xylem, phloem and resin canal).

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Bikunin is a proteoglycan exhibiting broad-spectrum inhibitory activity against serine proteases and could potentially suppress tumor cell invasion and metastasis. Here, we have successfully expressed recombinant human bikunin (rh-bikunin) in Pichia pastoris and also established the purification procedure. Different fusion genes of h-UTI and domain I, domain I and domain II, domain I, domain II and domain III of human serum albumin (HSA) were inserted into expression vector pPICZαA.

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