A Nomogram Combined Radiomics and Kinetic Curve Pattern as Imaging Biomarker for Detecting Metastatic Axillary Lymph Node in Invasive Breast Cancer.

To construct and validate a nomogram model integrating the magnetic resonance imaging (MRI) radiomic features and the kinetic curve pattern for detecting metastatic axillary lymph node (ALN) in invasive breast cancer preoperatively. Materials and Methods: A total of 145 ALNs from two institutions were classified into negative and positive groups according to the pathologic or surgical results. One hundred one ALNs from institution I were taken as the training cohort, and the other 44 ALNs from institution II were taken as the external validation cohort.

[Mixed logit model and its application in insurance choices of the new rural cooperative medical system].

Objective: To apply mixed logit model for analyzing the data of new rural cooperative medical with suitability and identify the factors affecting the residents choices of insurance mode.

Methods: Hypothesis test of IIA was performed using the mogtest module of Stata10.0 to test the eligibility of the condition.

A novel dual PI3Kalpha/mTOR inhibitor PI-103 with high antitumor activity in non-small cell lung cancer cells.

PI-103, the first synthetic multitargeted compound which simultaneously inhibits PI3Kalpha and mammalian target of rapamycin (mTOR) shows high antitumor activity in glioma xenografts. In the present study, clear antitumor activity was observed with PI-103 treatment in two gefitinib-resistant non-small cell lung cancer (NSCLC) cell lines, A549 and H460, by simultaneously inhibiting p70s6k phosporylation and Akt phosphorylation in response to mTOR inhibition. In addition, H460 cells with activating mutations of PIK3CA were more sensitive to PI-103 than A549 cells with wild-type PIK3CA.

Contribution of Kv channel subunits to glutamate-induced apoptosis in cultured rat hippocampal neurons.

Potassium channel dysfunction has been implicated in apoptosis in many pathological conditions. However, which Kv channel subunit is involved in glutamate-induced apoptosis remains unknown. In this study, the contributions of nine Kv alpha and three Kv beta subunits to glutamate-induced hippocampal neuronal apoptosis were investigated.

[An age-period-cohort modelling study on primary liver cancer incidence rate in Qidong].

Objective: To analyze the incidence trends of primary liver cancer (PLC) in Qidong.

Methods: Data of PLC incidence from 1975 to 1999 in Qidong were analyzed to delineate temporal trends and birth cohort patterns, using age-period-cohort models.

Results: Significant moderation or decreasing trends were began to notice in incidence rates on cohorts born in 1913 - 1917 and 1958 - 1962.