Publications by authors named "Qi-Gao Zhang"
Article Synopsis
- The study aimed to understand how epicardial adipocytes change their characteristics during the development of coronary atherosclerosis, focusing on potential molecular mechanisms.
- The experiment involved 30 male rabbits divided into two groups: one group was fed a high-fat diet to induce atherosclerosis, while the control group received normal food.
- Results showed a decrease in essential fat-burning markers (UCP-1 and PPARγ) and an increase in leptin, indicating a shift in adipose tissue phenotype; IL-6 was identified as a key factor in this conversion through the JAK-STAT3 signaling pathway.
Objective: To investigate the correlation of CTRP9 with coronary atherosclerosis.
Methods: Coronary angiography confirmed CAD in 241 patients (62 received CABG) and non-CAD in 121 (55 received valve replacement).
Results: Serum levels of LDL-C, CRP, TNF-α, IL-6, and leptin in CAD patients were significantly higher than those in non-CAD patients (P < 0.
An 82-year-old female patient undergoing cardiogenic shock caused by atrioventricular junctional rhythm immediately after percutaneous coronary intervention (PCI) is described. Pharmacotherapy was invalid, and subsequent application of atrial pacing reversed the cardiogenic shock. PCI-related injury of sinuatrial nodal artery leading to acute atrial contractility loss, accompanied by atrioventricular junctional arrhythmia, was diagnosed.
View Article and Find Full Text PDF[Impact of anti-OX-LDL antibodies on CD36 mRNA expression in monocytes].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
September 2012
Aim: To investigate the impact of antibodies to oxidized low-density lipoprotein (OX-LDL) on CD36 mRNA expression in monocytes and explore the mechanism underlying the impact on the formation of foam cells.
Methods: U937 cells and the monocytes of New Zealand rabbit were respectively cultured in vitro and divided into 4 groups: the control group (cultured in nutrient medium of RPMI1640), the OX-LDL group (with additional OX-LDL of 50 μg/L in nutrient medium), the OX-LDL+Ab-OX-LDL group (with additional OX-LDL of 50 μg/L and Ab-OX-LDL of 100 μg/L in nutrient medium) and the Ab-OX-LDL group (with additional Ab-OX-LDL of 100 μg/L in nutrient medium). After 24-hour culture, the expression of CD36 mRNA was detected by semi-quantitative RT-PCR.
[Membrane testosterone receptors in cultured vascular smooth muscle cells].
Zhonghua Nan Ke Xue
May 2010
Objective: To determine the presence of membrane testosterone receptors in cultured vascular smooth muscle cells (VSMC), and investigate their relationship with classical intracellular androgen receptors (iAR).
Methods: VSMCs were cultured from the thoracic aorta of male Sprague-Dawley rats by the explant method. Subconfluent VSMCs were incubated with serum-free medium for 24 h to obtain quiescent non-dividing cells, and then treated with the indicated agents.
Objective: To explore the acute effects of testosterone at the physiological level on PGF2alpha-induced increase in intracellular Ca2+ in cultured vascular smooth muscle cells (VSMCs).
Methods: VSMCs from the thoracic aorta of male Sprague-Dawley rats were cultured using the explant method. The subconfluent VSMCs were incubated with serum-free medium for 24 hours to obtain quiescent non-dividing cells and then treated with the indicated agents.