Publications by authors named "Qi-Fang Yan"

Objective: To explore the cytotoxicity of concentrate growth factors (CGF) and the effects on the apoptosis, proliferation and differentiation of human dental pulp cells (hDPCs), which were closely correlated with future application of CGF in the treatment of dental pulpal and periapical diseases.

Methods: hDPCs were isolated from permanent teeth extracted for orthodontic purpose, and expanded . hDPCs were treated with CGF and mineral trioxide aggregate (MTA) respectively.

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Article Synopsis
  • The study investigated the effects of concentrate growth factor extracts (CGFe) on human umbilical vein endothelial cells (HUVECs) in a controlled lab setting.
  • Four groups of varying CGFe concentrations (2%, 5%, 10%, and control) were used to assess how these extracts influenced cell growth, movement, and specific gene expressions related to blood vessel formation.
  • Results showed that CGFe enhanced cell proliferation and migration in a dose-dependent manner and increased the expression of important growth factors, suggesting CGFe's potential role in dental pulp treatment.
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