CAFs-derived TIAM1 Promotes OSCC Cell Growth and Metastasis by Regulating ZEB2.

Previous studies have suggested that cancer-associated fibroblasts (CAFs) within the tumor microenvironment are a critical factor in tumorigenesis and tumor development. However, the regulatory mechanisms of CAFs on oral squamous cell carcinoma (OSCC) are poorly defined. A CAF-conditioned medium (CAF-CM) was collected and applied to culture OSCC cells.

Efficacy and Safety of Anti-Programmed Cell Death Protein 1/Programmed Death-Ligand 1 Antibodies Plus Chemotherapy as First-Line Treatment for NSCLC in the People's Republic of China: a Systematic Review and Meta-Analysis.

Introduction: The available approved anticancer drugs for Chinese patients are relatively limited because of China's low participation rate in international clinical trials. Therefore, a focus on approved anti-programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) drugs in China is needed. This study aims to assess the heterogeneity of anti-PD-1/PD-L1 antibodies manufactured in China (domestic PD-1/PD-L1) and overseas (imported PD-1/PD-L1) when combined with chemotherapy as the first-line treatment of NSCLC.

Driving forces of digital transformation in chinese enterprises based on machine learning.

With advanced science and digital technology, digital transformation has become an important way to promote the sustainable development of enterprises. However, the existing research only focuses on the linear relationship between a single characteristic and digital transformation. In this study, we select the data of Chinese A-share listed companies from 2010 to 2020, innovatively use the machine learning method and explore the differences in the predictive effects of multi-dimensional features on the digital transformation of enterprises based on the Technology-Organization-Environment (TOE) theory, thus identifying the main drivers affecting digital transformation and the fitting models with stronger predictive effect.

A study on the influencing factors of corporate digital transformation: empirical evidence from Chinese listed companies.

In an era where digital technology is reshaping business landscapes, understanding the factors that drive corporate digital transformation is essential. In this paper we explore these influencing factors, focusing on Chinese A-share listed companies from 2007 to 2021. Our approach involved a comprehensive analysis of multiple variables through regression techniques to determine their impact on digital transformation.

Study on the impact of digital transformation on the innovation potential based on evidence from Chinese listed companies.

Digital transformation has emerged as a powerful force in reshaping the business landscape and enabling organizations to enhance their capabilities. One critical aspect of this change is how it impacts an enterprise's innovation ability. To explore this question, we select data regarding China's A-share listed enterprises from 2007 to 2021 as the research sample.

Outcomes following KRAS inhibitor treatment in patients with KRAS-mutated solid tumors: A systematic review and meta-analysis.

Objective: To assess the efficacy and safety of FDA-approved KRAS inhibitors in patients with KRAS-mutated solid tumors.

Methods: We searched PubMed, EMBASE, Cochrane Library, and major international conferences for clinical trials published in English up to March 6, 2023. Clinical trials investigating sotorasib or adagrasib and reporting the clinical outcomes of the objective response rate (ORR), disease control rate (DCR), or incidence rate of grade ≥ 3 adverse events (AEs) were eligible.

Large-scale sports events, sports gambling market and promotion risk management: Theoretical model and case analysis based on option hedging theory.

Large-scale sports events have become a good opportunity for major enterprises to promote due to their high social attention; however, they also force enterprises to confront the risks of uncertainty and extreme loss. During the 2018 Russia World Cup, Vatti Co., Ltd.

Preparation and Properties of Fluorosilicone Fouling-Release Coatings.

To improve the antifouling performance of silicone fouling-release coatings, some fluorosilicone and silicone fouling-release coatings were prepared and cured at room temperature with hydroxyl-terminated fluoropolysiloxane (FPS) or hydroxy-terminated polydimethylsiloxane (PDMS) as a film-forming resin, tetraethyl orthosilicate (TEOS) as a crosslinking agent, and dibutyltin dilaurate (DBTDL) as a catalyst. The chemical structure, surface morphology and roughness, tensile properties, and antifouling properties of the coating were studied by infrared spectroscopy, a laser confocal scanning microscope, contact angle measurement, tensile tests, and marine bacteria and benthic diatom attachment tests. The results showed that the FPS coatings were not only hydrophobic but also oleophobic, and the contact angles of the FPS coatings were larger than those of the PDMS coatings.

Preserving Minority Structures in Graph Sampling.

Sampling is a widely used graph reduction technique to accelerate graph computations and simplify graph visualizations. By comprehensively analyzing the literature on graph sampling, we assume that existing algorithms cannot effectively preserve minority structures that are rare and small in a graph but are very important in graph analysis. In this work, we initially conduct a pilot user study to investigate representative minority structures that are most appealing to human viewers.