Polydatin retards the progression of osteoarthritis by maintaining bone metabolicbalance and inhibiting macrophage polarization.

Background: Polydatin (PD), also known as tiger cane glycoside, is a natural compound extracted from the Japanese knotweed plant, which is often referred to as white resveratrol. It exhibits anti-inflammatory, antioxidant, and anti-apoptotic effects in the treatment of various diseases. However, the potential molecular mechanisms of PD in osteoarthritis have not been clearly elucidated.

WKB ameliorates DSS-induced colitis through inhibiting enteric glial cells activation and altering the intestinal microbiota.

Background: Inflammatory bowel disease (IBD) is a chronic condition influenced by diet, which affects gut microbiota and immune functions. The rising prevalence of IBD, linked to Western diets in developing countries, highlights the need for dietary interventions. This study aimed to assess the impact of white kidney beans (WKB) on gut inflammation and microbiota changes, focusing on their effects on enteric glial cells (EGCs) and immune activity in colitis.

LDHAα, a lactate dehydrogenase A isoform, promotes glycolysis and tumor progression.

Lactate dehydrogenase A (LDHA) is upregulated in multiple cancer types and contributes to the Warburg effect. Several studies have found that many tumor-related genes have subtypes and play important roles in promoting cancer development. Here, we identified a novel LDHA transcript, which produced a new protein 3 kDa larger than LDHA, which we named LDHAα.

Coffee Consumption, Additive Use, and Risk of Type 2 Diabetes- Results from Three Large Prospective US Cohort Studies.

Background: Consumption of coffee has been consistently associated with lower risk of type 2 diabetes (T2D). However, it is unknown whether the use of additives may modify the association.

Objective: To study the association between coffee consumption and risk of T2D by considering the addition of sugar, artificial sweeteners, cream or a non-dairy coffee whitener.

Adiponectin regulates proliferation and differentiation of chicken skeletal muscle satellite cells via ERK1/2 and p38 signaling pathways.

Skeletal muscle satellite cells (SMSCs) are critical for postnatal skeletal muscle growth and regeneration. Adiponectin plays a pivotal role in regulating muscle glucose uptake and fatty acid metabolism. However, its function in the proliferation and differentiation of chicken SMSCs remains poorly understood.

The Clinical Outcomes of Arthroscopic Tenotomy versus Tenodesis with Medium-to-Massive Rotator Cuff Tear in the Elderly: A Retrospective Study.

Purpose: Shoulder arthroscopic repair of rotator cuff tears with simultaneous treatment of lesions of the long head of the biceps tendon has become increasingly accepted. However, the clinical outcomes between tenotomy and tenodesis remain unclear. This study aimed to compare the efficacy of tenotomy and tenodesis combined with rotator cuff repair in elderly patients with medium-to-massive rotator cuff tears.

Association of a healthy lifestyle index with anthropometric indices and obesity in Hong Kong Chinese women: Evidence from the MECH-HK cohort study.

Aim: This cross-sectional study aimed to examine the associations of a healthy lifestyle index (HLI) with several anthropometric indices and obesity among Hong Kong Chinese women.

Subjects/methods: A total of 3174 women (56.16 ± 8.

Monounsaturated fatty acids from plant or animal sources and risk of type 2 diabetes in three large prospective cohorts of men and women.

Aims/hypothesis: Existing evidence on the relationship between intake of monounsaturated fatty acids (MUFAs) and type 2 diabetes is conflicting. Few studies have examined whether MUFAs from plant or animal sources (MUFA-Ps and MUFA-As, respectively) exhibit differential associations with type 2 diabetes. We examined associations of intakes of total MUFAs, MUFA-Ps and MUFA-As with type 2 diabetes risk.

CT Predictors of Angiolymphatic Invasion in Non-Small Cell Lung Cancer 30 mm or Smaller.

Background Angiolymphatic invasion (ALI) is an important prognostic indicator in non-small cell lung cancer (NSCLC). However, few studies focus on radiologic features for predicting ALI in patients with early-stage NSCLCs 30 mm or smaller. Purpose To identify radiologic features for predicting ALI in NSCLCs 30 mm or smaller in maximum diameter.

A lineage 1 branch porcine reproductive and respiratory syndrome virus live vaccine candidate provides broad cross-protection against HP-like PRRSV in piglets.

Multiple porcine reproductive and respiratory syndrome virus (PRRSV) subtypes coinfect numerous pig farms in China, and commercial PRRSV vaccines offer limited cross-protection against heterologous strains. Our previous research confirmed that a PRRSV lineage 1 branch attenuated live vaccine (SD-R) provides cross-protection against HP-PRRSV, NADC30-like PRRSV and NADC34-like PRRSV. HP-PRRSV has undergone significant genetic variation following nearly two decades of evolution and has transformed into a subtype referred to as HP-like PRRSV, which also exhibits high pathogenicity.

Lignan Intake and Mortality Among Adults with Incident Type 2 Diabetes-Prospective Cohort Studies.

Background: Lignans are polyphenolic compounds abundant in plant-based foods such as seeds, whole grains, and certain fruits and vegetables and may lead to favorable metabolic health. It remains to be elucidated regarding the role of lignan consumption in the etiology of premature deaths among individuals with diabetes.

Objectives: To prospectively examine the association between post-diagnosis lignan intake and mortality among individuals with type 2 diabetes (T2D).

Co-occurrence of microplastics, PFASs, antibiotics, and antibiotic resistance genes in groundwater and their composite impacts on indigenous microbial communities: A field study.

There is a major gap in the occurrence of mixed emerging contaminants, which hinders our efforts in exploring their behaviors and transport in environmental media, as well as their toxicity to human and ecosystem. This study assessed the occurrence and their correlations of mixed contamination by microplastics (MPs), per- and polyfluoroalkyl substances (PFASs), antibiotics, and antibiotic resistance genes (ARGs) in groundwater collected from a pharmaceutical and chemical industrial park. MPs, PFASs, antibiotics and ARGs were detected at all monitoring wells.

Coffee drinking timing and mortality in US adults.

Background And Aims: To identify the patterns of coffee drinking timing in the US population and evaluate their associations with all-cause and cause-specific mortality.

Methods: This study included 40 725 adults from the National Health and Nutrition Examination Survey 1999-2018 who had complete information on dietary data and 1463 adults from the Women's and Men's Lifestyle Validation Study who had complete data on 7-day dietary record. Clustering analysis was used to identify patterns of coffee drinking timing.

Genome-Wide Identification and Expression Analysis of Gene Family Members in Seashore Paspalum Under Salt Stress.

The gene family plays a crucial role in plant growth, development, and responses to biotic and abiotic stresses. , a warm-season turfgrass with exceptional salt tolerance, can be irrigated with seawater. However, the gene family in seashore paspalum remains poorly understood.

Size-specific clonidine-loaded liposomes: Advancing melanoma microenvironment suppression with safety and precision.

The immunosuppressive tumor microenvironment (TME) plays a crucial role in the progression and treatment resistance of melanoma. Modulating the TME is thus a key strategy for enhancing therapeutic outcomes. Previousstudies have identified clonidine (CLD), an α2-adrenergic receptor agonist, as a promising agent that enhances T lymphocyte infiltration and reduces myeloid-derived suppressor cells within the TME, thereby promoting antitumor immune responses.

Diagnostic value of digital continuous bowel sounds in critically ill patients with acute gastrointestinal injury: A prospective observational study.

Background: Acute gastrointestinal injury (AGI) is common in intensive care unit (ICU) and worsens the prognosis of critically ill patients. The four-point grading system proposed by the European Society of Intensive Care Medicine is subjective and lacks specificity. Therefore, a more objective method is required to evaluate and determine the grade of gastrointestinal dysfunction in this patient population.

Strategic analysis of avian conservation within key areas and key species - A case study of Baiyangdian, China.

Global climate change and extensive human activities are causing rapid transformations in natural ecosystems, leading to the rapid loss of suitable habitats for wildlife, which urgently requires measures to protect global biodiversity. In the past decade, China has invested heavily in ecological restoration, but current projects often do not prioritize biodiversity conservation. Therefore, developing systematic conservation strategies and using quantitative methods to identify conservation key areas and key species within a regional scale is of great importance for current ecological restoration.

[Preparation of Silicon-based Magnetic Biochar and Its Remediation Mechanism for Cd（Ⅱ） and As（Ⅲ） Co-contaminated Water].

Cadmium （Cd） and arsenic （As） often coexist in water and agricultural soils around mining areas, and it is difficult to remove them at the same time due to their opposite chemical behaviors. Therefore, this study employed a co-precipitation-pyrolysis method to synthesize silica-based magnetic biochar （SMB） materials for the remediation of water contaminated with both Cd and As. The optimization of preparation conditions involved introducing three different types of silicates （NaSiO, CaSiO,and SiO） into the biomass-magnetite mixture, followed by pyrolysis at various temperatures （300℃, 500℃, and 700℃）, and the optimal preparation conditions were determined based on the composite batch experiments.

Topotactic Transformation in FeO Induces Spontaneous Growth of Compositionally Diverse Nanostructures.

Topotactic transformation is an emerging strategy for synthesizing materials with exotic functional properties. In this report, instead of producing new crystals with related structures, we exploited the topotactic transformation phenomenon to spontaneously produce compositionally diverse nanostructures on the transforming substrate. The surface of magnetite nanoparticles (FeO NPs) is topotactically transformed into maghemite (γ-FeO).

Electrochemical synthesis of nitrosation compounds using CHNO as a nitroso reagent.

An electrochemical synthesis of various nitroso organic compounds (NOCs) from secondary amines was developed under metal-free and oxidant-free conditions. This method used commercially available nitromethane as the nitrosation reagent to provide various NOCs in good to excellent yields. Furthermore, the valuable drug molecule form desloratadine can be prepared by this method easily.

Associations of vitamin D levels and clinical parameters with COVID-19 infection, severity and mortality in hemodialysis patients: A cohort study.

Introduction: Vitamin D deficiency is prevalent among patients undergoing hemodialysis. This study aimed to investigate the associations between vitamin D levels and clinical parameters with the risk of COVID-19 infection, severity, and mortality in hemodialysis patients with end-stage kidney disease (ESKD).

Methods: This retrospective cohort study included 198 hemodialysis patients from a single center.

Chronic sleep deprivation disturbs energy balance modulated by suprachiasmatic nucleus efferents in mice.

Background: Epidemiologic researches show that short sleep duration may affect feeding behaviors resulting in higher energy intake and increased risk of obesity, but the further mechanisms that can interpret the causality remain unclear. The circadian rhythm is fine-tuned by the suprachiasmatic nucleus (SCN) as the master clock, which is essential for driving rhythms in food intake and energy metabolism through neuronal projections to the arcuate nucleus (ARC) and paraventricular nucleus (PVN).

Results: We showed that chronic SD-induced aberrant expressions of AgRP/NPY and POMC attributed to compromised JAK/STAT3 signals and reduced energy expenditure in the mice, which can be rescued with AAV-genetic overexpression of BMAL1 into SCN.

Study on the preparation and mechanism of environmentally friendly polysaccharide-xanthan gum gel dust suppressants.

In response to the dust pollution problem in open-pit mines, an environmentally friendly network structure with a dust suppressor structure was prepared by grafting acrylamide (AM) monomers onto xanthan gum (XG). The results show that the polymer produced from 1 g XG, 15 g AM, and 0.45 g trimethylolpropane triglycidyl ether (TTE) had a more orderly structured gel with a viscosity of 81.

Do Similar Objects Have Similar Grasp Positions?

In robotic grasping tasks, shape similarity has been widely adopted as a reference in grasp positions prediction for unknown objects. However, to the best of our knowledge, the issue "do similar objects have similar grasp positions?" has not been quantitatively analyzed before. This work aims to confirm or disprove the question by analyzing the relationship between the object shape similarity and grasp positions similarity.

A Novel Detection Scheme for Motor Bearing Structure Defects in a High-Speed Train Using Stator Current.

Railway traction motor bearings (RTMB) are critical components in high-speed trains (HST) that are particularly susceptible to failure due to the high stress and rotational frequency they experience. To address the challenge of high false-positive rates in existing monitoring systems, this paper introduces a novel sensorless monitoring scheme that leverages stator current to detect fault-related characteristics, eliminating the need for additional sensors. This approach employs a hybrid signal preprocessing algorithm that integrates adaptive notch filtering (ANF) with envelope spectrum analysis (ESA) to effectively sparse the stator current and extract relevant fault features.