Interleukin-33 Knockout Promotes High Mobility Group Box 1 Release from Astrocytes by Acetylation Mediated by P300/CBP-Associated Factor in Experimental Autoimmune Encephalomyelitis.

High mobility group box 1 (HMGB1), when released extracellularly, plays a pivotal role in the development of spinal cord synapses and exacerbates autoimmune diseases within the central nervous system. In experimental autoimmune encephalomyelitis (EAE), a condition that models multiple sclerosis, the levels of extracellular HMGB1 and interleukin-33 (IL-33) have been found to be inversely correlated. However, the mechanism by which IL-33 deficiency enhances HMGB1 release during EAE remains elusive.

Tribenzyl Organic Cations Carried Multidentate X-Type Lewis Soft Base for High-Performance Foldable Perovskite Light-Emitting Diodes.

Lead-halide perovskite nanocrystals (PNCs) exhibit significant potential for advancing foldable perovskite light-emitting diodes (F-PLEDs) due to their discrete crystalline morphology, bright emission across an extensive color gamut, and remarkable color purity; however, their progression remains in the early stages with the concerns of inadequate performance and mechanical instability. This study proposes a ligand strategy employing tribenzyl organic cation (tribenzylamine, TBA) carried multidentate X-type Lewis soft base (sodium acid pyrophosphate, SAPP) to address the challenges above simultaneously. Specifically, the use of multibranched aromatic ligands considerably improved the adhesion force between PNCs and adjacent layers, enhancing mechanical stability during folding, while the control sample shows deleterious cracks.

Parthenolide ameliorates diabetic retinopathy by suppressing microglia-induced Müller cell gliosis and inflammation via the NF-κB signalling.

Diabetic retinopathy (DR) is characterized by retinal inflammation and gliosis and the interaction between Müller cells and microglia plays a crucial role in DR pathogenesis. A sesquiterpene lactones, Parthenolide (PTL), has potent anti-inflammatory effects. This study aimed to evaluate the efficacy of PTL in ameliorating DR and the underlying mechanisms.

Molecular architecture of human LYCHOS involved in lysosomal cholesterol signaling.

Lysosomal membrane protein LYCHOS (lysosomal cholesterol signaling) translates cholesterol abundance to mammalian target of rapamycin activation. Here we report the 2.11-Ã… structure of human LYCHOS, revealing a unique fusion architecture comprising a G-protein-coupled receptor (GPCR)-like domain and a transporter domain that mediates homodimer assembly.

Designing Zwitterionic Bottlebrush Polymers to Enable Long-Cycling Quasi-Solid-State Lithium Metal Batteries.

Ionogel polymer electrolyte (IPE), incorporating ionic liquid (IL) within a polymer matrix, presents a promising avenue for safe quasi-solid-state lithium metal batteries. However, sluggish Li kinetics, resulting from the formation of [Li(anion)] clusters and the occupation of Li transport sites by organic cations, limit their practical applications. In this study, we have developed zwitterionic bottlebrush polymers-based IPE with promoted Li conduction by employing poly(sulfobetaine methacrylate)-grafted poly(vinylidene fluoride-co-chlorotrifluoroethylene) (PVC-g-PSBMA) bottlebrushes as matrices of IL.

Assessment of anterior scleral thickness in myopes and emmetropes using anterior segment optical coherence tomography.

Purpose: To investigate the differences in anterior scleral thickness (AST) among the refractive statuses of Chinese adults aged 18-35.

Methods: This study recruited 170 Chinese participants (mean age, 24.06 ± 2.

Supramolecular Crystals based Fast Single Ion Conductor for Long-Cycling Solid Zinc Batteries.

The solid polymer electrolytes (SPEs) used in Zn-ion batteries (ZIBs) have low ionic conductivity due to the sluggish dynamics of polymer segments. Thus, only short-range movement of cations is supported, leading to low ionic conductivity and Zn transference (t ). Zn-based supramolecular crystals (ZMCs) have considerable potential for supporting long-distance Zn transport; however, their efficiency in ZIBs has not been explored.

Rational Design and Stereodivergent Construction of Enantioenriched Tetrahydro-β-Carbolines Containing Multistereogenic Centers.

Chiral tetrahydro-β-carbolines, as one of the most intriguing subtypes of indole alkaloids, have emerged as the privileged units in plenty of natural products and biologically active molecules with an impressive range of bioactive properties. However, the stereodivergent construction of these valuable skeletons containing multistereogenic centers from readily available starting materials remains very challenging, especially, in view of the introduction of an axial chirality. Herein, we developed an efficient method toward enantioenriched tetrahydro-β-carbolines with readily available tryptophan-derived aldimine esters and allylic carbonates under mild reaction conditions.

Constructing a Janus Catholyte/Cathode Structure: A New Strategy for Stable Zn-Organic Batteries.

Organic materials are promising candidates for the electrodes of aqueous zinc-ion batteries due to their nonmetallic nature, environmental friendliness, and cost-effectiveness. However, they often suffer from significant dissolution during the charge-discharge process, which poses a major hurdle to their practical applications. Inspired by membrane-less organelles in cells, a simple and versatile strategy is proposed-constructing a Janus catholyte/cathode structured electrode based on liquid-liquid phase separation, in which redox-active organic molecules are confined in the liquid state within the activated carbon, thereby eliminating the volume effect and preventing their diffusion into the electrolyte.

Hydroxychloroquine as an add-on therapy for the induction therapy of MPO-AAV: a retrospective observational cohort study.

Background: The remission rate of myeloperoxidase (MPO)-antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) patients who received standard induction therapy is far from satisfactory. Improving the remission rate of MPO-AAV patients is essential. Hydroxychloroquine (HCQ), one of the classic antimalarial drugs, has been widely used in various autoimmune rheumatic diseases.

The analysis of GM (1, 1) grey model to predict the health resource allocation in Jilin Province, China: An observational study.

To predict the development of health resource allocation in Jilin Province during the 14th 5-Year Plan period, and to provide a scientific basis for promoting the improvement of its service capacity. The data of the health resource from 2015 to 2022 were obtained from the Jilin Statistical Yearbook, and the number of medical institutions, medical beds, health technicians, licensed (assistant) physicians, registered nurses and pharmacists were selected as evaluation indicators, and the grey prediction model constructed by Python was used to predict the development from 2023 to 2025. In the 14th 5-Year Plan period, the health resource in Jilin Province showed an increasing trend, and it is predicted that in 2025, the number of medical institutions, medical beds, health technicians, licensed (assistant) physicians, registered nurses, and pharmacists in Jilin Province will reach 28,999, 196,328, 262,219, 101,273, 129,586, and 9469, respectively.

A retrospective study of anlotinib in patients with persistent, recurrent or metastatic cervical and endometrial cancer.

Background: The prognosis of persistent, recurrent or metastatic cervical and endometrial cancer is poor. Anlotinib is a novel multitarget tyrosine kinase inhibitor (TKI). The efficacy and safety of anlotinib in patients with cervical and endometrial cancer need to be evaluated.

A drug-mediated organic electrochemical transistor for robustly reusable biosensors.

Reusable point-of-care biosensors offer a cost-effective solution for serial biomarker monitoring, addressing the critical demand for tumour treatments and recurrence diagnosis. However, their realization has been limited by the contradictory requirements of robust reusability and high sensing capability to multiple interactions among transducer surface, sensing probes and target analytes. Here we propose a drug-mediated organic electrochemical transistor as a robust, reusable epidermal growth factor receptor sensor with striking sensitivity and selectivity.

Role of ZNF334 in cervical cancer: implications for EMT reversal and tumor suppression.

Zinc-finger proteins are involved in many biological processes. However, the role of Zinc-finger protein 334 (ZNF334) in cervical cancer remains unidentified. This study showed that promoter methylation of ZNF334 was responsible for its reduced expression.

Quantifying Asymmetric Zinc Deposition: A Guide Factor for Designing Durable Zinc Anodes.

Zinc metal is recognized as the most promising anode for aqueous energy storage but suffers from severe dendrite growth and poor reversibility. However, the coulombic efficiency lacks specificity for zinc dendrite growth, particularly in Zn||Zn symmetric cells. Herein, a novel indicator (f) based on the characteristic crystallization peaks is proposed to evaluate the growth and distribution of zinc dendrites.

Metastatic adult Wilms' tumor managed by chemotherapy, immunotherapy and target therapy: a case report.

Wilms' tumor is a rare type of tumor in adult. Herein, we reported a case of 37-year-old female with adult Wilms' tumor (AWT) admitted in our institution. After a multidisciplinary team discussion, she underwent receiving immunotherapy plus chemotherapy and VEGF-targeted therapy.

Pattern-Matched Polymer Ligands Toward Near-Perfect Synergistic Passivation for High-Performance and Stable Br/Cl Mixed Perovskite Light-Emitting Diodes.

Mixed Br/Cl perovskite nanocrystals (PeNCs) exhibit bright pure-blue emission benefiting for fulfilling the Rec. 2100 standard. However, phase segregation remains a significant challenge that severely affects the stability and emission spectrum of perovskite light-emitting diodes (PeLEDs).

Inhibiting Residual Solvent Induced Side Reactions in Vinylidene Fluoride-Based Polymer Electrolytes Enables Ultra-Stable Solid-State Lithium Metal Batteries.

Residual solvents in vinylidene fluoride (VDF)-based solid polymer electrolytes (SPEs) have been recognized as responsible for their high ionic conductivity. However, side reactions by the residual solvents with the lithium (Li) metal induce poor stability, which has been long neglected. This study proposes a strategy to achieve a delicate equilibrium between ion conduction and electrode stability for VDF-based SPEs.

Trigeminal nerve electrical stimulation attenuates early traumatic brain injury through the TLR4/NF-κB/NLRP3 signaling pathway mediated by orexin-A/OX1R system.

Background: Traumatic brain injury (TBI) is a significant contributor to global mortality and disability, and emerging evidence indicates that trigeminal nerve electrical stimulation (TNS) is a promising therapeutic intervention for neurological impairment following TBI. However, the precise mechanisms underlying the neuroprotective effects of TNS in TBI are poorly understood. Thus, the objective of this study was to investigate the potential involvement of the orexin-A (OX-A)/orexin receptor 1 (OX1R) mediated TLR4/NF-κB/NLRP3 signaling pathway in the neuroprotective effects of TNS in rats with TBI.

Safety evaluation of single-sperm cryopreservation technique applied in intracytoplasmic sperm injection.

Intracytoplasmic sperm injection (ICSI) is a technique that directly injects a single sperm into the cytoplasm of mature oocytes. Here, we explored the safety of single-sperm cryopreservation applied in ICSI. This retrospective study enrolled 186 couples undergoing ICSI-assisted pregnancy.