Anthropogenic pressure induced discontinuities of microbial communities along the river.

Microorganisms play a fundamental role in driving biogeochemical functions within rivers. Theoretically, the directional flowing nature of river contributes to the continuous downstream change pattern of microbial communities. This continuity is anticipated to be influenced by human activities as anthropogenic materials lead to the mixing of environmental substances and their resident microorganisms with local communities.

Comparative analysis of niche adaptation strategies of AOA, AOB, and comammox along a gate-controlled river-estuary continuum.

Ammonia oxidizers are key players in the biogeochemical nitrogen cycle. However, in critical ecological zones such as estuaries, especially those affected by widespread anthropogenic dam control, our understanding of their occurrence, ecological performance, and survival strategies remains elusive. Here, we sampled sediments along the Haihe River-Estuary continuum in China, controlled by the Haihe Tidal Gate, and employed a combination of biochemical and metagenomic approaches to investigate the abundance, activity, and composition of ammonia-oxidizing archaea (AOA), ammonia-oxidizing bacteria (AOB), and complete ammonia oxidizers (comammox).

The prevalence of occult malignancy in women undergoing hysterectomy or myomectomy for benign indications and the impact of morcellation on survival outcomes: a meta-analysis.

Introduction Uterine fibroids (UFs), also known as leiomyomas, are the most common benign gynecological tumors. Currently, morcellation is discouraged owing to the risk of disseminating undetected malignancies. This study aims to update the prevalence data on occult malignancies in surgeries for suspected benign uterine lesions and analyze the impact of treatment strategies on survival outcomes in patients with occult malignancies.

Nuclear remodeling during cell fate transitions.

Totipotent stem cells, the earliest cells in embryonic development, can differentiate into complete embryos and extra-embryonic tissues, making them essential for understanding both development and regenerative medicine. This review examines recent advances in the dynamic remodeling of nuclear structures during the transition between totipotency and pluripotency, as well as other cell fate transition processes. Additionally, we highlight innovative experimental and computational methods that elucidate the relationship between nuclear architecture and cell fate decisions.

Association of short-term exposure to PM with hospital admission from total and cause-specific respiratory diseases.

Background And Objective: Evidence of short-term exposure to particulate matter with an aerodynamic diameter ≤1 μm (PM) on hospital admission for respiratory diseases (RDs) is limited. We aimed to estimate the associated risk of PM on hospital admissions for RDs.

Methods: In this time-stratified case-crossover study, we assigned cases who had been admitted to hospital for RDs in Guangdong, China between 2016 and 2019.

Murray anthocyanin-driven neuroprotection modulates the gut microbiome and metabolome of MPTP-treated mice.

Emerging evidence suggests that Parkinson's disease (PD) is strongly associated with altered gut microbiota. The present study investigated the prophylactic effects of anthocyanins (ACNs) from Murray on Parkinson's disease based on microbiomics and metabolomics. In this study, sixty-six adult male C57BL/6J mice were randomized into the control group, model group, positive drug (Madopar) group, and low-, medium- and high-dose ACN groups.

Effects of Nurse-Led e-Health Interventions on the Health-Related Outcomes of Pregnant Women: A Systematic Review.

Background: Pregnancy is a special time for women that involves substantial emotional, physical, social, and family changes, which can lead to physical and psychological harm. The rapid development of e-health has provided a favourable platform for managing health-related outcomes in pregnant women, and nurses are the professional group that is most likely to provide e-health services. Nurse-led e-health interventions have attracted increasing attention, but their effects are uncertain.

The Mediation Effect of Academic Self-Efficacy on Academic Procrastination, Performance, and Satisfaction of Chinese Local Technology University Undergraduates.

Purpose: To identify the relationship between academic procrastination, performance, self-efficacy, and satisfaction, we investigate the mediational role of academic self-efficacy between academic procrastination and satisfaction, and between academic performance and satisfaction, respectively, among undergraduate students of local technology universities in China.

Methods: A cross-sectional study was conducted involving 388 undergraduate students from 22 local technology universities in Hubei, China. Data was collected through an online questionnaire measuring academic procrastination, performance, self-efficacy, and satisfaction.

Impact of salting-in/out assisted extraction on rheological, biological, and digestive, and proteomic properties of Tenebrio molitor larvae protein isolates.

In this study, NaCl (salting-in) and (NH4)SO (salting-out) treatments were employed in alkaline extraction and acid precipitation procedures, respectively, to enhance the extraction of Tenebrio molitor larvae protein isolates (TPIs). The in vitro digestibility, rheological properties, biological activities, and proteomic analysis of TPIs were investigated. The results showed that salting-in treatment did not result in significant differences (P > 0.

Diagnostic value of serum vascular endothelial growth factor and interleukin-17 in primary hepatocellular carcinoma.

Background: Despite significant advancements in the medical treatment of primary hepatocellular carcinoma (PHC) in recent years, enhancing therapeutic effects and improving prognosis remain substantial challenges worldwide.

Aim: To investigate the expression levels of serum vascular endothelial growth factor (VEGF) and interleukin (IL)-17 in patients with PHC and evaluate their diagnostic value while exploring their relationship with patients' clinical characteristics.

Methods: The study included 50 patients with confirmed PHC who visited Wuhan Hanyang Hospital from January 2021 to January 2022, and 50 healthy individuals from the same period served as the control group.

Impact of anatomic variability and other vascular factors on lamina cribrosa hypoxia.

Insufficient oxygenation in the lamina cribrosa (LC) may contribute to axonal damage and glaucomatous vision loss. To understand the range of susceptibilities to glaucoma, we aimed to identify key factors influencing LC oxygenation and examine if these factors vary with anatomical differences between eyes. We reconstructed 3D, eye-specific LC vessel networks from histological sections of four healthy monkey eyes.

AFM-YOLOv8s: An Accurate, Fast, and Highly Robust Model for Detection of Sporangia of with Various Morphological Variants.

Monitoring spores is crucial for predicting and preventing fungal- or oomycete-induced diseases like grapevine downy mildew. However, manual spore or sporangium detection using microscopes is time-consuming and labor-intensive, often resulting in low accuracy and slow processing speed. Emerging deep learning models like YOLOv8 aim to rapidly detect objects accurately but struggle with efficiency and accuracy when identifying various sporangia formations amidst complex backgrounds.

Efficacy Analysis of Anti-Tuberculosis Chemotherapy Combined with Arthroplasty or Joint Replacement for Tuberculous of the Elbow Joint: A Retrospective Study of 40 Patients.

Tuberculous arthritis of the elbow joint (TAEJ) is a relatively rare infectious bone and joint disease. Misdiagnosed owing to inconspicuous early symptoms, often the elbow joint has suffered serious damage at the time of treatment. This study retrospectively investigated the clinical manifestations, population characteristics, clinical diagnosis, surgical treatment, and functional recovery of elbow joint tuberculosis (TB).

Inflammatory Role of CCR1 in the Central Nervous System.

Background: Chemokine ligands and their corresponding receptors are essential for regulating inflammatory responses. Chemokine receptors can stimulate immune activation or inhibit/promote signaling pathways by binding to specific chemokine ligands. Among these receptors, CC chemokine receptor 1 (CCR1) is extensively studied as a G protein-linked receptor target, predominantly expressed in various leukocytes, and is considered a promising target for anti-inflammatory therapy.

Water-Involved Carbon-Nitrogen Triple-Bond Monomer Based Polymerization toward Processable Functional Polyamides under Ambient Conditions.

Polyamide plays a pivotal role in engineering thermoplastics. Constrained by the harsh conditions and arduous procedures for its industrial synthesis, developing facile synthesis of polyamides is still challengeable and holds profound significance. Herein, we successfully utilized water as one of the monomers to synthesize functional polyamides under ambient conditions.

Ppb-Level Ammonia Sensor for Exhaled Breath Diagnosis Based on UV-DOAS Combined with Spectral Reconstruction Fitting Neural Network.

Ammonia (NH) in exhaled breath (EB) has been a biomarker for kidney function, and accurate measurement of NH is essential for early screening of kidney disease. In this work, we report an optical sensor that combines ultraviolet differential optical absorption spectroscopy (UV-DOAS) and spectral reconstruction fitting neural network (SRFNN) for detecting NH in EB. UV-DOAS is introduced to eliminate interference from slow change absorption in the EB spectrum while spectral reconstruction fitting is proposed for the first time to map the original spectra onto the sine function spectra by the principle of least absolute deviations.

Fast-iTPN: Integrally Pre-Trained Transformer Pyramid Network With Token Migration.

We propose integrally pre-trained transformer pyramid network (iTPN), towards jointly optimizing the network backbone and the neck, so that transfer gap between representation models and downstream tasks is minimal. iTPN is born with two elaborated designs: 1) The first pre-trained feature pyramid upon vision transformer (ViT). 2) Multi-stage supervision to the feature pyramid using masked feature modeling (MFM).

Inductive State-Relabeling Adversarial Active Learning With Heuristic Clique Rescaling.

Active learning (AL) is to design label-efficient algorithms by labeling the most representative samples. It reduces annotation cost and attracts increasing attention from the community. However, previous AL methods suffer from the inadequacy of annotations and unreliable uncertainty estimation.