Prognostic value of JAK3 promoter methylation and mRNA expression in clear cell renal cell carcinoma.

Introduction: Janus kinase 3 (JAK3) is a well-established oncogene in clear cell renal cell carcinoma (ccRCC). The methylation status of oncogene promoters has emerged as biomarkers for cancer diagnosis and prognosis.

Objective: This study aims to investigate the biological and clinical significance of JAK3 promoter methylation in ccRCC.

National Land Use Regression Model for NO Using Street View Imagery and Satellite Observations.

Land use regression (LUR) models are widely applied to estimate intra-urban air pollution concentrations. National-scale LURs typically employ predictors from multiple curated geodatabases at neighborhood scales. In this study, we instead developed national NO models relying on innovative street-level predictors extracted from Google Street View [GSV] imagery.

Mechanisms of Sodium/Iodide Symporter-Mediated Mammary Gland Iodine Compensation during Lactation.

This research aimed to investigate the compensation mechanism of iodine deficiency and excess in the mammary gland during lactation. Female rats were divided into the low iodine group (LI), the normal iodine group (NI), the 10-fold high iodine group (10HI) and the 50-fold high iodine group (50HI). We measured the iodine levels in the urine, blood, milk, and mammary gland.

An Analysis of the Cultivation Methods of Visual Communication Design in New Media Environment.

In order to better adapt to the teaching development needs of visual communication design in the new media environment, a method of visual communication design training based on the ecological environment of the new media environment is proposed. This method constructs a web-based professional course network teaching platform by cultivating practical design talents under the new platform, new environment, and new technology, starting from the perspective of practical application, starting from the teaching process of visual communication design specialty, combined with the needs of social development for students' creative needs, so as to provide rich visual communication design cases, design practice, and exchange and discussion platform for professional teaching. The results show that the local display time of the system page is too long.

Molecular detection and characterization of Enterocytozoon bieneusi in captive alpine musk deer (Moschus chrysogaster) in Central and Eastern of Gansu Province, China.

The most ubiquitously diagnosed microsporidian species in animals and humans is Enterocytozoon bieneusi (E. bieneusi). In this case, this work aimed to probe the occurrence and genotypes of this pathogen in captive alpine musk deer (Moschus chrysogaster) in Gansu Province, China.

Chiral cyclic architectonics with tetraphenylethylenes: conformation immobilization, optical resolution and circularly polarized luminescence.

Chiral cyclic tetraphenylethylenes (TPEs) were synthesized by cyclization with chiral binaphthols. The helical conformation can be immobilized and multi-isomers can be separated resulting from (/)-isomerism and helical chirality of TPE. The chiral cyclic TPEs can emit deep blue circularly polarized luminescence (CPL) in both solution and film states.

Investigating Accessibility of Hospitals in Cold Regions: A Case Study of Harbin in China.

Objective: The objective of this study is to explore healthcare resource accessibility in Harbin, a typical city in a cold region in China.

Background: Recently, investments in the construction of medical resources have been increasing annually in China, and consequently, the allocation of these resources has improved. Snow and ice on surfaces in China's cold regions have certain effects on the traffic capacity of urban roads, leading to a great difference in the accessibility of medical resources in winter and summer.

Mechanism of 17β-estradiol degradation by Rhodococcus equi via the 4,5-seco pathway and its key genes.

Steroid estrogens have been detected in oceans, rivers, lakes, groundwaters, soils, and even urban water supply systems, thereby inevitably imposing serious impacts on human health and ecological safety. Indeed, many estrogen-degrading bacterial strains and degradation pathways have been reported, with the 4,5-seco pathway being particularly important. However, few studies have evaluated the use of the 4,5-seco pathway by actinomycetes to degrade 17β-estradiol (E2).

A Deep Learning Method for Motion Artifact Correction in Intravascular Photoacoustic Image Sequence.

In vivo application of intravascular photoacoustic (IVPA) imaging for coronary arteries is hampered by motion artifacts associated with the cardiac cycle. Gating is a common strategy to mitigate motion artifacts. However, a large amount of diagnostically valuable information might be lost due to one frame per cycle.

Recent advances in MXenes and their composites for wearable sensors.

Flexible wearable sensors have attracted significant interests and created high technological impact on human health monitoring, environmental pollutant detection and bimolecular identification. For sensors, the choice of sensing materials is a crucial priority. As a rising star in the family of two-dimensional materials, MXenes has metal-like electrical properties, adjustable surface chemical property, hydrophilicity and excellent mechanical properties, making them attractive for building different high-performance sensors.

Concentration Optimization of Localized Cu and Cu on Cu-Based Electrodes for Improving Electrochemical Generation of Ethanol from Carbon Dioxide.

Copper-based electrodes can catalyze electroreduction of CO to two-carbon products. However, obtaining a specific product with high efficiency depends on the oxidation state of Cu for the Cu-based materials. In this study, Cu-based electrodes were prepared on fluorinated tin oxide (FTO) using the one-step electrodeposition method.

Biochemical characterization of medaka (Oryzias latipes) fibrinogen gamma and its gene disruption resulting in anemia as a model fish.

At the final stages of blood coagulation, fibrinogen is processed into insoluble fibrin by thrombin resulting in fibril-like structure formation. Via further cross-linking reactions between the fibrin gamma subunit by the catalytic action of blood transglutaminase (Factor XIII), this molecule gains further physical stability. Meanwhile, since fibrinogen is expressed in various cells and tissues, this molecule can exhibit other functions apart from its role in blood coagulation.

MiR-942-5p targeting the IFI27 gene regulates HCT-8 cell apoptosis via a TRAIL-dependent pathway during the early phase of Cryptosporidium parvum infection.

Background: MicroRNAs (miRNAs) are involved in the regulation of both the innate and adaptive immune response to Cryptosporidium parvum infection. We previously reported that C. parvum upregulated miR‑942‑5p expression in HCT‑8 cells via TLR2/TLR4‑NF‑κB signaling.

A novel intergenic region ALK fusion is targetable by alectinib in a non-small cell lung cancer patient with brain metastasis.

Anaplastic lymphoma kinase ( ALK ) rearrangement defines a unique nonsmall cell lung cancer (NSCLC) molecular subtype, of which the patients could potentially benefit from anti- ALK therapies. So far, the outcomes of the canonical echinoderm microtubule-associated protein-like ( EML-ALK ) patients subjected to ALK inhibitors are well established. However, given the increasing complexity of ALK fusion partners, as detected by high-throughput sequencing, the responses of those with rare ALK fusion events remain to be explored.

Evolutionarily conserved role of hps1 in melanin production and blood coagulation in medaka fish.

Hermansky-Pudlak syndrome is an autosomal recessive disease characterized by albinism, visual impairment, and blood platelet dysfunction. One of the genes responsible for Hermansky-Pudlak syndrome, hps1, regulates organelle biogenesis and thus plays important roles in melanin production, blood clotting, and the other organelle-related functions in humans and mice. However, the function of hps1 in other species remains poorly understood.

Enhancing Organizational Citizenship Behaviors for the Environment: Integrating Social Identity and Social Exchange Perspectives.

Purpose: Based on social identity theory and social exchange theory, this study tests the influence of green organizational identity, exchange ideology and perceived organizational support toward the environment on organizational citizenship behaviors for the environment.

Methods: This study conducted a three-wave survey. The data was collected from 526 employees (95% response rate) across three organizations.

MXene-Derived 3D Defect-Rich TiO@Reduced Graphene Oxide Aerogel with Ultrafast Carrier Separation for Photo-Assisted Uranium Extraction: A Combined Batch, X-ray Absorption Spectroscopy, and Density Functional Theory Calculations.

Encapsulation of nano-semiconductor materials in three-dimensional (3D) adsorbents to build a typical semiconductor-adsorbent heterostructure is a forward-looking strategy for photo-assisted uranium extraction. Here, we develop 3D MXene-derived TiO(M)@reduced graphene oxide (RGO) aerogel for photo-assisted uranium extraction. Theoretical simulations demonstrate that oxygen vacancies on TiO(M) tailor the energy level structure and enhance the electron accumulation at gap states of TiO(M), thereby further realizing the spatial separation efficiency of electron-hole pairs by the Schottky junction.

Innovation in Boundary-Spanning Technology M&A: A Fuzzy-Set Analysis of Diversity Dynamics.

The growing literature on organizational innovation has drawn attention from net effect and contingent effect of diversity-related factors in the context of top management teams (TMTs) to their complementarity and interaction in the form of configurations. In post-boundary-spanning technology mergers & acquisitions (M&A), the integration between multi-boundary knowledge and resources necessitates effective communication and cooperation within TMTs that display heterogeneous attributes. Therefore, this study integrates two popular theoretical perspectives from the diversity literature (social categorization perspectives and information/decision-making perspectives) in order to explore the configurational patterns of factors stimulating innovation in boundary-spanning technology M&A (BTM&A).

A Drop-in, Focus-Extending Phase Mask Simplifies Microscopic and Microfluidic Imaging Systems for Cost-Effective Point-of-Care Diagnostics.

Microscopic imaging and imaging flow cytometry have wide potential in point-of-care assays; however, their narrow depth of focus necessitates precise mechanical or fluidic focus control of a sample in order to acquire high-quality images that can be used for downstream analysis, increasing the cost and complexity of the imaging system. This complexity represents a barrier to miniaturization and translation of point-of-care assays based on microscopic imaging or imaging flow cytometry. To address this challenge, we present a simple drop-in phase mask with a physics-informed, circularly symmetric asphere phase profile that extends the depth of focus by >5-fold while largely preserving the image quality compared to other depth extending methods.

Novel miRNA Biomarkers for Patients With Duchenne Muscular Dystrophy.

Creatine kinase (CK) as a biomarker has long been expected to be replaced by other fluid biomarkers for Duchenne muscular dystrophy (DMD) because it is independent of disease severity. Growing evidence has demonstrated that muscle-specific microRNAs, known as myomiRs, can act as biomarkers for monitoring muscle pathology and disease severity of DMD patients. To gain insights into the relationship between serum myomiRs and clinical assessment, we measured serum levels of miR-1, miR-133a, miR-133b, miR-206, miR-208a, miR-208b, and miR-499 in 48 DMD patients by using real-time quantitative reverse transcription polymerase chain reaction.

A sustainable closed-loop method of selective oxidation leaching and regeneration for lithium iron phosphate cathode materials from spent batteries.

A sustainable closed-loop method for recovering waste lithium iron phosphate batteries is developed in this paper. Li was selectively leached from cathode materials in a system of NaHSO and HO. Under the optimal conditions of leaching temperature of 65 °C, 1.

Long Noncoding RNA CASC2 Facilitated Wound Healing through miRNA-155/HIF-1 in Diabetic Foot Ulcers.

Diabetic foot ulcers (DFU) are among the serious complications which are closely linked to diabetes mellitus. However, there is still a lack of accurate and effective standard prevention and treatment programs for DFU. In this manuscript, we have investigated the function of lncRNA cancer susceptibility candidate 2 (CASC2)/miR-155/hypoxia-inducible factor 1-alpha (HIF-1) in the wound healing of DFU.

Molecular detection and genetic characterization of Cryptosporidium in kindergarten children in Southern Xinjiang, China.

Cryptosporidium is a common cause of diarrhea in children globally. However, there is limited information on the prevalence and genetic characteristics of Cryptosporidium in children in Xinjiang, China. This study aimed to assess the genetic characteristics and epidemiological status of Cryptosporidium in kindergarten children in Southern Xinjiang, China.

Effects of Soundscape on Flow State during Diabolo Exercise.

“Soundscape” is defined as “an acoustic environment as perceived or experienced and/or understood by a person or people, in context.” The research focuses on the physical properties of sound, paying attention to the relationship between the soundscape and people. Sports provide a comprehensive context, including the athletes, their behavior, the environment, spectators, and other elements.