Diet, Polycyclic Aromatic Hydrocarbons, and Oxidative Stress Biomarkers in Pregnancy: a Los Angeles Pregnancy Cohort.

Polycyclic aromatic hydrocarbon (PAH) exposure during pregnancy has been associated with increased oxidative stress. Few studies have evaluated the relationship between diet, urinary PAHs, and oxidative stress biomarkers among pregnant women. We enrolled a prospective cohort of pregnant women who gave birth at UCLA between 2016-2019.

Monte Carlo Neural PDE Solver for Learning PDEs Via Probabilistic Representation.

In scenarios with limited available data, training the function-to-function neural PDE solver in an unsupervised manner is essential. However, the efficiency and accuracy of existing methods are constrained by the properties of numerical algorithms, such as finite difference and pseudo-spectral methods, integrated during the training stage. These methods necessitate careful spatiotemporal discretization to achieve reasonable accuracy, leading to significant computational challenges and inaccurate simulations, particularly in cases with substantial spatiotemporal variations.

Association between composite dietary antioxidant index and rheumatoid arthritis: results from NHANES 2003-2018.

: Increasing evidence has revealed oxidative stress as an essential risk factor in the development of rheumatoid arthritis (RA). Composite dietary antioxidant index (CDAI) is an important tool for assessing dietary antioxidant capacity. However, the association between CDAI and RA is still unclear.

Effect of Ascites Syndrome on Diversity of Cecal Microbiota of Broiler Chickens.

Ascites syndrome (AS) is a metabolic disease that seriously affects the growth and development of broiler chickens. Intestinal microbiota play a significant role in the growth of broiler chickens. Therefore, further research on the relationship between AS and intestinal microbiota will help to better understand the impact of AS on broiler growth.

Potential neural mechanisms of acupuncture therapy on migraine: a systematic review and activation likelihood estimation meta-analysis update.

Background: Migraine is a common, disabling, chronic headache disorder. Acupuncture is one of the effective complementary therapies for migraine. However, the neural mechanisms of acupuncture on migraine remain unclear.

GraphSleepFormer: a multi-modal graph neural network for sleep staging in OSA patients.

Obstructive sleep apnea (OSA) is a prevalent sleep disorder. Accurate sleep staging is one of the prerequisites in the study of sleep-related disorders and the evaluation of sleep quality. We introduce a novel GraphSleepFormer (GSF) network designed to effectively capture global dependencies and node characteristics in graph-structured data.

Silver Molybdate Nanoparticles for Enhanced Tumor Immunotherapy through Pyroptosis Conversion and Ferroptosis Induction.

Pyroptosis holds great potential in tumor therapy due to its strong immunogenicity. Several strategies, including ion interference therapy (IIT), are developed to induce pyroptosis. However, the mechanism by which metal oxoanions induced pyroptosis remained unclear.

Molecular characterization and subtype analysis of Blastocystis sp. in captive wildlife in Henan, China.

Blastocystis sp. is a zoonotic intestinal protozoan that is ubiquitous globally, residing in the gastrointestinal tracts of both humans and various animals. In the present study, a PCR-sequencing tool based on the SSU rRNA gene was employed to investigate the prevalence and subtypes of Blastocystis spp.

Residual and pharmacokinetic behavior of berberine in Carassius auratus under intraperitoneal injection conditions by HPLC-Q-TOF/MS.

The present study investigated the distribution characteristics of Berberine (BBR) in Carassius auratus under artificial environmental conditions (temperature: 26 ± 1.0 °C; continuous air pumping) following a single administration via intraperitoneal injection of an appropriate dosage of 2.0 mg/Kg per body weight.

Neospora caninum Inhibits Lewis Cancer and B16f10 Melanoma Lung Metastasis Development by Activating the Immune Response in Murine Models.

Malignant tumors are prevalent with high mortality rates in humans, dogs, and cats. Some microorganisms have been shown to inhibit cancer progression. The objective of this study is to evaluate the inhibitory effects of Neospora caninum, a livestock parasite, on three different tumor models in C57BL/6 mice, including Lewis subcutaneous tumors, Lewis and B16F10 melanoma lung metastasis.

Curcumin-Loaded ZIF-8 Nanomaterials: Exploring Drug Loading Efficiency and Biomedical Performance.

Curcumin (cur) possesses excellent therapeutic properties, including anti-inflammatory, antioxidant, and healing-promoting effects. However, its biomedical application is impeded by its rapid degradation, limited bioavailability, and poor aqueous solubility. Zeolitic imidazole framework (ZIF-8), with a high surface area and tunable pore size, is designed and used as a cur delivery carrier to overcome these limitations.

Exploring the dynamic responses of group 3 innate lymphoid cells at different times in response to LPS challenge.

Group 3 innate lymphoid cells (ILC3s) have clear roles in regulating mucosal immunity and tissue homeostasis in the intestine, though the immunological functions in lungs remain unclear. This study aimed to demonstrate the dynamic responses of ILC3s to acute inflammation upon LPS challenge. Microarray data and single-cell RNA sequencing (scRNA-seq) data obtained from the GEO database were combined to analyze the function of ILC3 subset, confirmed by flow cytometry assay and qRT-PCR.

Molecular mechanism of interaction between SHORT VEGETATIVE PHASE and APETALA1 in Arabidopsis thaliana.

Point mutations were introduced into specific leucine (L) amino acids within the K domain of SHORT VEGETATIVE PHASE (SVP), and their effects on the SVP-AP1 interaction were assessed. Yeast two-hybrid experiments and β-galactosidase activity assays demonstrated that SVP maintained its capacity to interact with APETALA1 (AP1) despite point mutations at the 108th, 116th, 119th, and 127th leucine residues, where leucine was substituted with alanine (A). However, the mutation of the leucine residue at position 124 to alanine abolished the interaction between SVP and AP1 regardless of whether the mutation was singular or combined with others.

Estrogen Promotes the Proliferation and Migration of Endometrial Cancer Through the GPER-Mediated NOTCH Pathway.

This study aims to investigate the expression of GPER in EC, assess the impact of estrogen on the proliferation and migration of EC via GPER, and examine the potential role of GPER in mediating the NOTCH pathway to influence EC proliferation and migration. The expression of GPER and its correlation with clinicopathological features were investigated using clinical data. Cell proliferation was assessed through MTT and EdU assays, while cell migration ability was evaluated using wound healing and transwell assays.

Sabatier Principle Inspired Bifunctional Alloy Interface for Stable and High-Depth Discharging Zinc Metal Anodes.

Achieving stable Zn anodes that can effectively couple with Zn-free cathodes is essential for advancing high-performance Zn metal batteries. Here, we propose a Sabatier principle inspired bifunctional transition-metal (TM) interface to enable homogeneous Zn dissolution during discharging and dendrite-free Zn deposition during charging. Among various TM-coated Zn (TM@Zn) electrodes, Cu@Zn exhibits the highest reversibility and structural stability, attributed to the optimal interaction between Cu and Zn.

Efficacy and safety of laser acupuncture on osteoarthritis: a systematic review and meta-analysis.

Objectives: To perform a meta-analysis of previous studies investigating the effects of laser acupuncture on osteoarthritis.

Study Design: Systematic review and meta-analysis.

Methods: Randomized controlled trials (RCTS) on laser acupuncture for osteoarthritis were searched in the databases of PubMed, Embase, Cochrane Library, and Web of Science with a search deadline of 24 December 2023.

A real-world analysis of 1,823 hospitalized osteoporotic fractures in Northeast China.

Context: There are limited real-world data evidence assessing the clinical characteristics of hospitalized osteoporotic fractures in China.

Objective: To investigate the clinical characteristics of hospitalized major osteoporotic fractures in Northeast China.

Methods: We identified hospitalized fracture patients aged 50 and over from the First Affiliated Hospital of Jinzhou Medical University between January 1, 2018, and December 31, 2022.

Comparing PD-L1 and PD-1 inhibitors plus bevacizumab combined with hepatic arterial interventional therapies in unresetable hepatocellular carcinoma: A single-center, real-world study.

With the rise of anti-vascular endothelial growth factor antibody and programmed cell death-ligand 1 (PD-L1) regimens, particularly bevacizumab and atezolizumab, as first-line treatments for advanced hepatocellular carcinoma (HCC), there is a need to explore PD-L1 and programmed cell death 1 inhibitors in combination therapies for unresectable HCC (uHCC). Integrating systemic therapies with locoregional approaches is also emerging as a potent strategy. This study compares the outcomes of atezolizumab (PD-L1 inhibitor) and sintilimab (programmed cell death 1 inhibitor) with bevacizumab or its biosimilar, combined with hepatic arterial interventional therapies (HAIT) in uHCC patients.

Recent Advances in Strategies to Enhance Photodynamic and Photothermal Therapy Performance of Single-Component Organic Phototherapeutic Agents.

Photodynamic therapy (PDT) and photothermal therapy (PTT) have emerged as promising treatment options, showcasing immense potential in addressing both oncologic and nononcologic diseases. Single-component organic phototherapeutic agents (SCOPAs) offer advantages compared to inorganic or multicomponent nanomedicine, including better biosafety, lower toxicity, simpler synthesis, and enhanced reproducibility. Nonetheless, how to further improve the therapeutic effectiveness of SCOPAs remains a challenging research area.

Calcium Signalling in Neurological Disorders, with Insights from Miniature Fluorescence Microscopy.

Neurological disorders (NDs), such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and schizophrenia, represent a complex and multifaceted health challenge that affects millions of people around the world. Growing evidence suggests that disrupted neuronal calcium signalling contributes to the pathophysiology of NDs. Additionally, calcium functions as a ubiquitous second messenger involved in diverse cellular processes, from synaptic activity to intercellular communication, making it a potential therapeutic target.

IGFBP2 Promotes Proliferation and Glycolysis of Endometrial Cancer by Regulating PKM2/HIF-1α Axis.

Endometrial cancer (EC) is a worldwide gynecologic malignancies, with a remarking increase of incidence and mortality rates in recent years. Growing evidence indicates that glucose metabolism reprogramming is the most representative metabolic signature of tumor cells and exploring its modulatory function in EC development will promote identifying potential EC therapeutic targets. IGFBP2 is an insulin-like growth factor binding protein which is closely associated with a variety of metabolic diseases.