Publications by authors named "Qi Long Hu"
Article Synopsis
- Peptide modification allows for the creation of peptides with specific functions, and tryptophan is a prime candidate due to its unique chemical properties.* -
- The study presents a new method for modifying tryptophan and indole derivatives without using transition metals, utilizing triazine derivatives activated by triflic acid.* -
- The new functional group introduced can be used for further chemical reactions, specifically an inverse electron demand Diels-Alder reaction, enabling additional bioconjugation opportunities.*
Article Synopsis
- Two different forms of Mn(II)-bridged Silverton-type polyoxomolybdates were synthesized using hydrothermal methods.
- The resulting compounds, Na(HO)[Mn(UMoO)] and (NH)[KNa(μ-O)(HO)Mn(UMoO)]·4.6HO, displayed unique three-dimensional structures.
- One of the compounds showed high efficiency as a heterogeneous catalyst, achieving up to 99% yield in the condensation cyclization reaction producing various valuable pyrazoles.
Article Synopsis
- The integration of transition metal ions into polyoxometalates (POMs) enhances their structural diversity and functional properties.
- The study focuses on synthesizing two new Zn(II)-containing Silverton-type polyoxomolybdates, addressing the current lack of diversity in this area.
- One of the synthesized compounds has shown promise as an effective and recyclable catalyst for reactions involving 1,4-naphthoquinones and amines, leading to the creation of valuable medicinal compounds.
Article Synopsis
- Three new compounds were created using a specific acid ligand (Htba), silver ions (Ag), and Keggin-type anions in their structures.
- The compounds have unique structural features with different arrangements of silver-tba clusters and use polyanions as linking agents to enhance their spatial structure.
- As heterogeneous catalysts, these compounds effectively produce benzimidazoles from benzene-1,2-diamines and benzaldehydes, demonstrating high stability, excellent catalytic activity, and the ability to be reused multiple times.
Article Synopsis
- * A wide range of these derivatives were successfully produced, achieving high yields and strong selectivity for specific molecular arrangements.
- * The process also demonstrated impressive enantioselectivity, reaching up to 98:2 ratios by using a specific catalyst (DHQD)PHAL in further experiments.
Article Synopsis
- Classic paired associative stimulation can enhance synaptic plasticity in both animals and humans, showing promise for improving neurologic recovery, particularly post-stroke.
- This study investigates the effects of paired associative magnetic stimulation on recovery from lower limb motor dysfunction in spinal cord injury patients by measuring various motor and sensory functions, as well as overall health and depression levels.
- The research will involve 110 patients, randomly assigned to either an experimental group receiving active stimulation or a control group undergoing sham stimulation, with outcomes assessed at several intervals after the treatment begins.
Article Synopsis
- Two new isostructural complexes, I (cobalt) and II (nickel), were synthesized through solvothermal methods using a compound featuring carboxyphenoxy and terephthalate ligands.
- Both complexes were thoroughly analyzed using various techniques, including IR spectroscopy, X-ray diffraction, and thermogravimetric analyses, revealing their distinct two-dimensional structures.
- Magnetic studies showed that both complexes exhibit antiferromagnetic interactions, with specific distances between the metal centers being related to their structural configurations.
Article Synopsis
- Methionine (Met) is important for modifying peptides because of its unique thioether group, but it's more difficult to functionalize than cysteine.
- Currently, there are not many strategies available for modifying the Met residue selectively.
- The authors present a new method that is transition-metal-free and redox-neutral for diversifying Met, which can also be used to create cyclic peptides.
Article Synopsis
- * Researchers developed a new method for modifying cysteine-containing peptides/proteins using aryl thioethers, which allows for selective bioconjugation reactions that are efficient and safe to use.
- * Different aryl groups with various tags can be added, and by slightly altering the structure, the modified peptides can be adjusted to regenerate their original forms.
Article Synopsis
- * It details a novel Pd-catalyzed reaction that specifically targets tyrosine (Tyr) residues in peptides using a removable silanol protecting group, showcasing high selectivity.
- * The method is versatile, applicable to various hexapeptides and supports different olefins, expanding options for late-stage peptide modifications and introducing new protection strategies for Tyr in solid-phase peptide synthesis (SPPS).
Article Synopsis
- The study showcases the first highly selective three-component Povarov reaction involving anilines and aldehydes, driven by a chiral amine catalyst.
- A diverse range of substituted tetrahydroquinolines were produced, achieving moderate to good yields along with exceptional enantioselectivity and diastereoselectivity (up to 99% ee and >95:5 dr).
- Additionally, the reaction intermediates were effectively transformed into other useful chemical building blocks.