J Trace Elem Med Biol
December 2024
Background: Selenium can inhibit cervical cancers, but the specific mechanism of anti-cervical cancer is not fully understood.
Methods: In this study, we investigated the anti-cervical cancer effect of sodium selenite (SS) in vivo and in vitro to reveal the role of the phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) signaling pathway in terms of the mechanism. In vivo experiments, HeLa cell xenografts were constructed in BALB/c female nude mice, and then intraperitoneally injected with 3 mg/kg sodium selenite (SS) for 14 days.
Background: There is a dearth of information on the effects of bone conductive devices on temporal processing in individuals with single-sided deafness (SSD). This study investigates the effect of an adhesive bone conductive device on temporal processing in adults with SSD.
Methods: A prospective cohort study of temporal processing in adults with SSD was undertaken.
Background: The progression of triple-negative breast cancer is shaped by both tumor cells and the surrounding tumor microenvironment (TME). Within the TME, tumor-associated macrophages (TAMs) represent a significant cell population and have emerged as a primary target for cancer therapy. As antigen-presenting cells within the innate immune system, macrophages are pivotal in tumor immunotherapy through their phagocytic functions.
View Article and Find Full Text PDFAccumulating evidence indicates that maternal exposure to carbon black nanoparticles (CBNPs) during gestation can induce multiple system abnormalities in offspring, whereas its potential mechanism in respiratory disease is still largely unknown. In order to explore the effect of maternal exposure to CBNPs on offspring's lung and latent pathogenesis, we respectively established in vivo model of pregnant rats exposed to CBNPs and ex vivo model of lung epithelial cells treated with pups' serum of pregnant rats exposed to CBNPs. After maternal exposure to CBNPs, epithelial-mesenchymal transition (EMT) and fibrosis levels increased as a result of DDRGK1-mediated reticulophagy upregulated in offspring's lung.
View Article and Find Full Text PDFA large number of nanoparticles are produced and enter the aquatic environment, where they interact with each other, posing a potential threat to aquatic organisms. The toxicity of two types of nanoparticles (nCu and nSiO) on Nitzschia closterium f. minutissima (N.
View Article and Find Full Text PDFPhotoacoustic tomography (PAT), as a novel biomedical imaging technique, is able to capture temporal, spatial and spectral tomographic information from organisms. Organ-level multi-parametric analysis of continuous PAT images are of interest since it enables the quantification of organ specific morphological and functional parameters in small animals. Accurate organ delineation is imperative for organ-level image analysis, yet the low contrast and blurred organ boundaries in PAT images pose challenge for their precise segmentation.
View Article and Find Full Text PDFTong sheep, known for their superior meat quality and disease resilience, face breeding challenges due to low prolificacy, unlike Hu sheep, which exhibit higher fertility and growth rates. This study identified over 700,000 genetic variants between these breeds through pooled whole-genome sequencing. Functional analysis reveals key differences in pathways related to fat metabolism, insulin signaling, and cell cycle regulation.
View Article and Find Full Text PDFBackground And Objective: Acute exacerbation (AE) is often the fatal complication of idiopathic pulmonary fibrosis (IPF). Emerging evidence indicates that metabolic reprogramming and dysregulation of lipid metabolism are distinctive characteristics of IPF. However, the lipid metabolic mechanisms that underlie the pathophysiology of AE-IPF remain elusive.
View Article and Find Full Text PDFObjective: To evaluate the impact of connective tissue growth factor (CTGF) and inflammatory factors on the condition and prognosis of patients undergoing reperfusion therapy for acute ischemic stroke (AIS).
Methods: A retrospective analysis was conducted on 212 AIS patients who received reperfusion therapy at Wu Xi Traditional Chinese Medicine Hospital, Suqian Hospital of Traditional Chinese Medicine, The Affiliated Wuxi People's Hospital of Nanjing Medical University from January 2021 to January 2024. Patients were divided into a control group (modified Rankin Scale [mRS] score = 0-3, n = 132) and a study group (mRS score = 4-6, n = 80).
Multispectral photoacoustic tomography (PAT) is an imaging modality that utilizes the photoacoustic effect to achieve non-invasive and high-contrast imaging of internal tissues but also molecular functional information derived from multi-spectral measurements. However, the hardware cost and computational demand of a multispectral PAT system consisting of up to thousands of detectors are huge. To address this challenge, we propose an ultra-sparse spiral sampling strategy for multispectral PAT, which we named U3S-PAT.
View Article and Find Full Text PDFIntroduction And Objectives: Tumor-associated macrophages (TAM) can influence both cancer growth and chemoresistance, but the specific mechanisms involved in these processes in cholangiocarcinoma (CCA) are unclear.
Materials And Methods: We explored the distribution of TAM in CCA samples by multiplex immunofluorescence staining and tested the effects of TAM on CCA in vitro and in vivo. We then investigated the mechanisms underlying these effects using the Luminex assay, RNA sequencing, western blotting, flow cytometry, and co-immunoprecipitation.
Herein, we investigate the yield, micro-structures, rheological properties and bioactivities of new Ganoderma leucocontextum polysaccharide (GLP) obtained from Kangding via ultrasound combined mechanical wall-breaking extraction (UBE), and examine the effect of GLP as a structural and functional improver on the physicochemical, sensory, aromatic, water-holding capacity (WHC), textural, rheological, micro-structural and protein structural properties, and bioactivities of set fat-free goat yogurt (set-FGY). Through response surface optimisation, the extracted GLP achieved a maximum yield of 2.18 %, showing good apparent viscosity and elastic behaviour in 3 % aqueous solution as well as good micro-structure and significant anti-oxidant and anti-diabetic activities.
View Article and Find Full Text PDFDazhu glutinous rice wine is a well-known traditional Chinese rice wine, and many local factories and handicraft workshops use different fermentation methods to produce it. Still, the influence of fermentation processes on glutinous rice wine is unclear. This study aimed to compare the difference between the two fermentation methods in the quality and bacterial composition of Dazhu glutinous rice wine.
View Article and Find Full Text PDFThe microbial agents based on plant growth promoting rhizobacteria (PGPR) have become a hot topic in agricultural research, while the optimization of fermentation conditions for PGPR-based microbial agents still lack systematic research. The single-factor and orthogonal experiments were conducted to determine the optimal fermentation conditions of M1. The results indicated that the glycerol and shaker speed was the most significant factors that influence the number of bacteria of M1 fermentation liquid.
View Article and Find Full Text PDFObjective: To evaluate the protective effects of gentiopicroside (GPS) against reactive oxygen species (ROS)-induced NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation in endothelial cells, aiming to reduce atherosclerosis.
Methods: Eight-week-old male ApoE-deficient mice were randomly divided into 2 groups (n=10 per group): the vehicle group and the GPS treatment group. Both groups were fed a high-fat diet for 16 weeks.
Mar Biotechnol (NY)
December 2024
In recent years, CRISPR/Cas9 gene editing technology has emerged as a powerful genetic tool with potential application in aquaculture. Crassostrea gigas, as a valuable species in aquaculture, holds promising potential for genetic enhancement and breeding through gene editing. However, the lack of efficient promoters for driving exogenous gene expression poses a major obstacle in bivalve gene editing.
View Article and Find Full Text PDFSocial equity consists of opportunity equity and outcome equity, where outcome equity refers to the equitable distribution of resource, while opportunity equity refers to equivalent sets of opportunities to obtain a satisfactory outcome, ensuring equality in expected payoffs rather than the actual payoffs. Previous studies showed the existence of inequity aversion for opportunity inequality and identified some differences between opportunity equity and outcome equity in the behavior pattern of evaluation and reaction processes. However, the commonalities and distinctions in brain activity during the fairness decision-making of opportunity equity and outcome equity remain unclear.
View Article and Find Full Text PDFObjectives: This study aimed to investigate the characteristics of attentional capture by reward signals in individuals with depression during classical conditioning.
Methods: A variant of the additional singleton paradigm was adopted with a high- or low-reward signal as the prominent distracting stimulus. In Experiment 1, 46 participants with depressive symptoms and 46 healthy controls were asked to conduct a keypress response to the visual target.
Purpose: To analyze the correlation between obstructive sleep apnea (OSA) and hypoxia-inducible factor (HIF)-1, interleukin (IL)-6 and inducible nitric oxide synthase (iNOS) in patients complicated with OSA after lung transplantation. To identify serum markers of OSA after lung transplantation.
Methods: We retrospectively selected patients who planned to undergo lung transplantation between 2018 and 2020, including 25 without OSA before lung transplantation (group A), 20 with OSA after lung transplantation (group B), and 15 patients without OSA after lung transplantation (group C).
Purpose: To investigate the potential associations between unhealthy chrononutrition behaviors (meal timing, frequency, and regularity) and their combined impact on cardiometabolic risk in adolescence.
Methods: Chrononutrition behaviors were assessed using a 7-day ecological momentary assessment (EMA). The unhealthy chrononutrition score (ranging from 0 to 8) was determined based on late meal timing, low meal frequency, and meal irregularity.
Schizophrenia, a mental disorder characterized by delayed onset, high relapse rates, and significant disability, ranks among the top 20 contributors to the global burden of disease and poses a substantial public health challenge. Effective self-management is crucial for the recovery of individuals with schizophrenia, with medication experience playing a vital role. However, the underlying mechanisms and logical relationships remain elusive, hindering the development of effective self-management and enhancement strategies from the perspective of medication experience.
View Article and Find Full Text PDFCircular RNAs are a single-stranded non-coding RNAs and play an important role in the development of many diseases. Alternative polyadenylation (APA) regulates the gene 3'UTR length for controlling gene expressions. Although the APA mechanism has been widely studied in the development of diseases, there is no data on its role in the burned intestinal mucosa.
View Article and Find Full Text PDFPurpose: To explore the clinical efficacy of perforated Kirschner wire tension band in the treatment of Mayo IIA olecranon fracture.
Method: A retrospective study was conducted to analyze the clinical data of 96 adult patients with olecranon fractures of the ulna. Thirty-four cases underwent perforated Kirschner wire tension band fixation(group A), which included 21 males and 13 females, with an average age of 49.
Front Cell Dev Biol
November 2024
The family is essential for cell proliferation, differentiation, and metabolism, particularly in embryonic development and stem cell functions. However, the specific role of in porcine early embryonic development is not fully understood. This study observed high expression during the four-cell stage of porcine embryos.
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