N,S-doped TiC MXene quantum dots-anchored metal ruthenium: Efficient electrocatalyst for pH-universal hydrogen evolution reaction.

Electrocatalytic hydrogen evolution reaction (HER) via water splitting is a prospective technology for achieving the sustainable production of hydrogen. So, ruthenium-based electrocatalysts have been extensively studied. However, metallic ruthenium tends to agglomerate due to the high cohesive energy, resulting in decreased HER performance in practical usage.

Regulation of the Endocytosis System Using Ultrathin g-CN Nanosheets for Enhanced Photodynamic Therapy of Glioma.

Glioma is the most aggressive form of brain cancer. Photodynamic therapy (PDT) has emerged as a promising treatment method for glioma; however, its efficacy is often hindered by the blood-brain barrier (BBB) and the need for precise tumor cell targeting. In the present study, a facile strategy is found to enhance the penetration of the BBB and the internalization efficiency by exfoliating the (100) crystal plane of g-CN (CN) using liquid nitrogen, resulting in ultrathin graphitic carbon nitride (CN12) nanosheets with hydroxyl-rich surfaces.

Effects of post-polymerization conditions on the mechanical properties of 3D-printed dental resin nanocomposite.

Purpose: To investigate the optimal post-polymerization temperature and time to enhance the mechanical properties of three-dimensional (3D)-printed nanocomposites.

Methods: A control group of pure 3D-printed resin was used to fabricate specimens post-polymerized at 40 °C for 15 min (n = 6). Next, 3-wt% functionalized yttria-stabilized zirconia (YSZ) nanoparticles were dispersed in a 3D-printed resin to fabricate YSZ-based nanocomposites for the experimental groups.

Long-read genome sequencing reveals the sequence characteristics of pear self-incompatibility locus.

The S-RNase-based self-incompatibility locus (S-locus) in Petunia species contains 16-20 F-box genes, which collaboratively function in the recognition and subsequent degradation of non-self S-RNases, while distinguishing them from self S-RNase. However, the number of S-locus F-box genes (SFBBs) physically interacted with non-self S-RNases remains uncertain in Pyrus species. Utilizing Pacbio long-read sequencing, we successfully assembled the genome of pear cultivar 'Yali' (Pyrus bretschneideri), and identified 19 SFBBs from the Pyrus S-locus spanning approximately 1.

Automated segmentation by SCA-UNet can be directly used for radiomics diagnosis of thymic epithelial tumors.

Background: Automatic segmentation of thymic lesions in preoperative computed tomography (CT) images is crucial for accurate diagnosis but remains time-consuming. Although UNet is widely used in medical imaging, its performance is limited by the inherent drawbacks of convolutional neural networks (CNNs), such as restricted receptive fields and limited global context modeling, which affect segmentation efficiency.

Method: 712 patients with mediastinal lesions admitted to Shanghai General Hospital between October 2014 and January 2023 were included in the study.

Effect of Asystasia gangetica inclusion in the diet on the feed intake, growth performance, and meat quality of Muscovy ducks.

The rising cost of imported feedstuffs in poultry production is a significant concern for producers. Utilising local resources like Asystasia gangetica, a common perennial weed with high nutritional value, offers a promising alternative. Ducks can better digest high-fibre diets than chickens, making them ideal for this study, which evaluated the effects of pelleted diets containing various levels of A.

Molecular and Biological Characterization of an Isolate of Fusarium graminearum dsRNA mycovirus 4 (FgV4) from a New Host .

Wheat Fusarium crown rot (FCR), mainly caused by , is one of the most important diseases. Some mycoviruses are reported to have a hypovirulence trait and considered as a biocontrol agent for plant fungal diseases. In most cases, mycovirus biological effects have not been explored clearly.

How Do Glycine-Induced Bent Structures Influence Hierarchical Nanostructuring and Suprastructural Handedness in Short Peptide Assembly?

Despite the multiple roles of flexible and achiral Gly in regulating protein architectures and functions, its high flexibility is seldom exploited as a structural modulator in the design of self-assembling peptides. By using minimalistic peptide sequences, the effects of Gly insertions are investigated on the molecular conformation and the supramolecular morphology, focusing on Gly-induced bent structures and their impact on self-assembled nanostructures and handedness. Different backbone bending degrees are generated by varying Gly position, which in turn resulted in distinct hydrogen bonding modes and residue shifting upon dimerization, eventually leading to β-sheets and nanofibrils with opposite handedness.

Lectin-like oxidized low-density lipoprotein receptor-1 reduces 5-FU sensitivity in gastric cancer cells via JAK/STAT/NOX4 axis.

5-Fluorouracil (5-FU) is the primary chemotherapeutic agent for the clinical management of advanced gastric cancer (GC). However, the emergence of drug resistance remains an inescapable challenge. In drug-resistant cancer cells, prior treatments contribute to elevated oxidative stress, resulting in higher level of reactive oxygen species (ROS) compared to treatment-naïve cancer cells.

LAMP Assay Coupled with a Argonaute System for the Rapid Detection of Porcine Epidemic Diarrhea Virus.

Porcine epidemic diarrhea virus (PEDV) infection can lead to serious acute intestinal infectious disease, bringing huge economic losses to the pig industry. In addition to triggering an extremely high mortality rate for lactating piglets, there is currently a lack of effective treatments and vaccines. Therefore, rapid, accurate, sensitive, and specific detection of PEDV is critical for timely control.

The alteration of glutamate involved in the brain of Parkinson's disease patients using glutamate chemical exchange saturation transfer (GluCEST).

Increased levels of glutamate, a novel regulator of neuroinflammation, is involved in the pathogenesis of Parkinson's disease (PD). Although glutamate chemical exchange saturation transfer (GluCEST) is widely used in central nervous system (CNS) disorders, it has been less commonly used in clinical practice for PD. Here, to explore the clinical significance of variations in glutamate levels in the striatum and thalamus in PD, we included forty-nine PD patients and forty-four healthy controls (HCs).

Analysis of laser spot centroiding errors for laser acquisition system in gravitational wave detection missions.

In space-based gravitational wave detection, establishing ultra-long-distance and ultra-high-precision laser links between satellites is achieved through the laser acquisition and tracking system. The laser spot centroid positioning method, which offers low computational complexity and strong adaptability to beam shape, is currently the core measurement method during the laser acquisition phase. However, due to various interference factors encountered in practical tests, this algorithm often falls short of meeting the extremely high requirements.

Sabatier Principle Inspired Bifunctional Alloy Interface for Stable and High-Depth Discharging Zinc Metal Anodes.

Achieving stable Zn anodes that can effectively couple with Zn-free cathodes is essential for advancing high-performance Zn metal batteries. Here, we propose a Sabatier principle inspired bifunctional transition-metal (TM) interface to enable homogeneous Zn dissolution during discharging and dendrite-free Zn deposition during charging. Among various TM-coated Zn (TM@Zn) electrodes, Cu@Zn exhibits the highest reversibility and structural stability, attributed to the optimal interaction between Cu and Zn.

An involvement of a new zinc finger protein PbrZFP719 into pear self-incompatibility reaction.

This study indicated that the CCHC-type zinc finger protein PbrZFP719 involves into self-incompatibility by affecting the levels of reactive oxygen species and cellulose content at the tips of pollen tubes. S-RNase-based self-incompatibility (SI) facilitates cross-pollination and prevents self-pollination, which in turn increases the costs associated with artificial pollination in fruit crops. Self S-RNase exerts its inhibitory effects on pollen tube growth by altering cell structures and components, including reactive oxygen species (ROS) level and cellulose content.

The Effect of Nurse-led Preoperative Visits on Anxiety: An Integrative Review.

Purpose: This review aims to investigate the effectiveness of nurse-led preoperative visits for the reduction of presurgical anxiety. The review will explore the patterns and mechanisms through which these visits alleviate anxiety, identify the existing practice gaps, and suggest future directions for improvement. The findings will help health care providers choose appropriate visits for their patients.

Optimized contrast enhancement and homogeneity in aortic CT angiography: bolus tracking with personalized post-trigger delay.

Background: The bolus tracking technique has been used for decades, yet still faces the challenging task of determining the optimal scanning time for individuals. Our study aimed to assess the feasibility of a novel bolus tracking method with a personalized post-trigger delay (PTD) to optimize scanning time and achieve optimized enhancement and contrast homogeneity in aortic computed tomography angiography (CTA).

Methods: Participants undergoing aortic CTA with bolus tracking were prospectively assigned to two different groups: Group A with a fixed 6-second PTD and Group B with a personalized PTD.

A study on sleep quality under the shadow of school bullying: The interwoven effects of depressed mood, low self-esteem, and negative parenting practices.

Objective: The aim of this study was to reveal the relationship between school bullying and sleep quality in adolescents. It proposes a theoretical model where depressed mood, low self-esteem, and negative parenting practices serve as mediating variables, providing new directions and measures for preventing and treating school bullying and sleep disorders.

Methods: In this study, a total of 4483 middle school students from Anhui Province in China were selected anonymously to participate in a questionnaire survey.

APOC1 inhibit NKTCL doxorubicin sensitivity by promoting mitophagy.

NKTCL is a highly aggressive malignant tumor, especially prevalent in the southern regions of China. Although chemotherapy regimens based on ADM have achieved certain therapeutic effects in early treatment, the issue of ADM resistance severely limits the therapeutic efficacy and makes it difficult to improve patient survival rates. Our research results indicate that the expression level of APOC1 is closely related to the sensitivity of NKTCL cells to ADM.

Effect of Cold Deformation on the Microstructural and Property Uniformity of AlO/Cu Composites.

Copper matrix composites (Cu-MCs) have garnered significant attention due to their exceptional electrical, wear-resistant, and mechanical properties. Among them, AlO/Cu composites, reinforced with AlO, are a focal point in the field of high-strength, high-conductivity copper alloys, owing to their high strength, excellent electrical conductivity, and superior resistance to high-temperature softening. Cold deformation is an effective method for enhancing the mechanical properties of AlO/Cu composites.

The effects of mobile phone addiction on learning engagement of Chinese college students - the mediating role of physical activity and academic self-efficacy.

Background: With the widespread adoption of smartphones, mobile phone addiction has increasingly gained prominence among Chinese college students, exerting a profound and detrimental impact on their learning engagement. This study employs self-determination theory as a framework to examine the mechanisms through which mobile phone addiction affects students' learning engagement. Specifically, it examines the mediating effects of physical activity and academic self-efficacy in this relationship.

Occurrences of heavy metal in breast milk in China: Results of the third national breast milk survey.

To investigate the exposure of infants to heavy metal during lactation, breast milk from 24 provinces in China were detected. Among As, Cd, Cr, Hg, and Pb, the detection frequencies of As (85 %, 0.50 μg/L) and Cd (91 %, 0.

MRI evaluation of neuroprotective effects of Astragaloside Ⅳ on rotenone-induced late-stage Parkinson's disease mice.

Astragaloside Ⅳ (AS-Ⅳ) improved the motor behavior of Parkinson's disease (PD) mouse but the alteration of imaging in the PD mice brain was unclear. PD models were established by unilateral injection of rotenone (ROT) into the substantia nigra pars compacta (SNc) of mice. AS-Ⅳ (20 mg/kg) was intraperitoneally injected once daily for 14 days.

Enhancement of Osseointegration via Endogenous Electric Field by Regulating the Charge Microenvironments around Implants.

The regulation of the charged microenvironment around implants is an effective way to promote osseointegration. Although homeostasis of the charged microenvironment plays an integral role in tissues, current research is externally invasive and unsuitable for clinical applications. In this study, functional materials with different surface potential differences are prepared by changing the spatial layout of Ta and Ag on the surface of a Ti-6Al-4V alloy (TC4).

Heparin and Bivalirudin in Percutaneous Coronary Intervention for Acute Coronary Syndromes: A Review Article.

Acute coronary syndrome (ACS) is one of the most common leading global causes of mortality, encompassing ST-segment elevation myocardial infarction (STEMI), non-ST-segment elevation myocardial infarction (NSTEMI), and unstable angina (UA). Percutaneous coronary intervention (PCI) has become a pivotal therapeutic approach for ACS, underscoring the importance of anticoagulation strategies. Among the commonly employed anticoagulants in PCI, heparin and bivalirudin take precedence, with heparin serving as the archetypal choice.