Global burden of Alzheimer's disease and other dementias attributed to metabolic risks from 1990 to 2021: results from the global burden of disease study 2021.

Objective: The risk of Alzheimer's disease (AD) and other dementias increases with greater global exposure to metabolic risks, making this a crucial public health issue. This study aimed to report the metabolism-attributable global burden of AD and other dementias from 1990 to 2021.

Methods: The Global Burden of Disease Study (GBD) 2021 collected data on the number of deaths and disability-adjusted life-years (DALYs) related to AD and other dementias caused by metabolic risks, including high fasting plasma glucose (FPG) and high body mass index (BMI).

Comigration Behavior of Cr(VI) and Microplastics and Remediation of Microplastics-Facilitated Cr(VI) Transportation in Saturated Porous Media.

The study of the co-transport of Cr(VI) and microplastics (MPs) in porous media is important for predicting migration behavior and for achieving pollution removal in natural soils and groundwater. In this work, the effect of MPs on Cr(VI) migration in saturated porous media was investigated at different ionic strengths (ISs) and pHs. The results showed that pH 7 and low IS (5 mM), respectively, promoted the movement of Cr(VI), which was further promoted by the presence of MPs.

Abnormal eye movements: relationship with clinical symptoms and predictive value for Alzheimer's disease.

Background: Abnormal eye movements occur at the early stages of Alzheimer's disease (AD). However, the characteristics of abnormal eye movements of patients with AD and their relationship with clinical symptoms remain inconsistent, and their predictive value for diagnosing and monitoring the progression of AD remains unclear.

Methods: A total of 42 normal controls, 63 patients with mild cognitive impairment due to AD (AD-MCI), and 49 patients with dementia due to AD (AD-D) were recruited.

Efficient Quasi-Homogenous Photocatalysis Enabled by Molecular Nanophotocatalysts with Donor-Acceptor Motif.

Polymer semiconductors have attracted much attention for photocatalytic hydrogen evolution, but they typically exhibit micrometer-sized particles in water-suspension, causing severe loss in light absorption and exciton recombination. Here a molecular nanophotocatalyst featuring a donor-acceptor motif is presented that solution is processed via a facile stirring nanoprecipitation method assisted by hydrophilic surfactants, enabling an efficient quasi-homogenous hydrogen evolution. In contrast to the original bulk powder (heterogeneous system), these quasi-homogenous nanophotocatalysts exhibit significantly improved light-harvesting, water-wettability, and exciton dissociation, resulting in distinctly enhanced (by four-order-of-magnitude) photocatalytic hydrogen evolution rate.

Desorption Electrospray Ionization-Mass Spectrometry Imaging-Based Spatial Metabolomics for Visualizing and Comparing Ginsenosides and Lipids among Multiple Parts and Positions of the Root.

Ginsenosides and lipids are both bioactive ingredients for ginseng. Targeting these two categories of components, this study was designed to develop desorption electrospray ionization-mass spectrometry imaging approaches and spatial metabolomics strategies, achieving the visualization and differentiation among different parts of root (e.g.

Characteristics of dissolved organic matter and their role in membrane fouling during simultaneous sludge thickening and reduction using flat-sheet membranes.

Four parallel simultaneous sludge thickening and reduction reactors using flat-sheet membranes were employed for the aerobic digestion of sludge to explore the characteristics of dissolved organic matter and its membrane fouling effect. During the initial 8 days of using flat-sheet membranes for simultaneous sludge thickening and reduction (MSTR), a notable increase was observed in the concentrations of humic acids and compounds that resemble soluble microbial by-products in the effluent. Subsequently, a fluctuating trend in humic acid levels ensued, accompanied by a gradual decline in soluble microbial by-product-like substances.

A comprehensive evaluation on the associations between hearing and vision impairments and risk of all-cause and cause-specific dementia: results from cohort study, meta-analysis and Mendelian randomization study.

Background: Epidemiological studies show inconsistent links between hearing/vision impairment and dementia risk. Using multisource data, we investigated how single or combined sensory impairments relate to risks of all-cause and specific types of dementia.

Methods: We employed a triangulation approach combining three methodologies.

Lewis Acid Sites in Hollow Cobalt Phytate Micropolyhedra Promote the Electrocatalytic Water Oxidation.

The acid-base microenvironment of the metal center is crucial for constructing advanced oxygen evolution reaction (OER) electrocatalysts. However, the correlation between acidic site and OER performance remains unclear for cobalt-based catalysts. Herein, Lewis acid sites in hollow cobalt phytate micropolyhedra (M-CoPA, M = Cu, Sr) were synthesized by a cation-exchange strategy, and their OER performances were studied systematically.

-Heterocyclic Carbene-Catalyzed [3 + 3] Annulation of Enals with Aminonaphthoquinones for the Synthesis of Functionalized Aza-anthraquinones.

Rapid construction of functionalized aza-anthraquinones has been successfully developed via NHC-catalyzed formal [3 + 3] annulation of 2-aminoquinones with enals. This reaction features several advantages, such as readily available starting materials, mild reaction conditions, and flexible product transformations. The study on the atroposelective version of this strategy was also carried out, and several C-N axial chiral aza-anthraquinones were synthesized in moderate yields with moderate to good enantioselectivities.

Prospective cohort study on the clinical significance of interferon-γ, D-dimer, LDH, and CRP tests in children with severe mycoplasma pneumonia.

Background: Mycoplasma pneumoniae is a significant cause of respiratory infections in children, often leading to severe pneumonia. This study aimed to assess the clinical relevance of interferon-gamma (interferon-γ), D-dimer, lactate dehydrogenase (LDH), and C-reactive protein (CRP) as biomarkers in the severity of mycoplasma pneumonia in pediatric patients.

Methods: In this prospective study, 203 pediatric patients with mycoplasma pneumonia were classified into mild (123 patients) and severe (80 patients) groups.

Outcomes of First-Line Microwave Ablation of Treatment-Naive Epidermal Growth Factor Receptor-Mutated Advanced Lung Adenocarcinoma Treated with Tyrosine Kinase Inhibitors.

Purpose: To investigate the outcomes of first-line image-guided microwave ablation (MWA) plus tyrosine kinase inhibitors (TKIs) in untreated epidermal growth factor receptor (EGFR)-mutant advanced lung adenocarcinoma (LUAD) and to compare with TKIs alone.

Materials And Methods: This retrospective cohort study included patients between December 2015 and December 2021 and was divided into 2 groups (Group A: first-line MWA+TKIs; Group B: TKIs alone). Progression-free survival (PFS) was the primary end point, whereas overall survival (OS) was the secondary end point and were compared via the Kaplan-Meier methods.

Magnetic nanobead assisted the dual targets driven fluorescent biosensor based on SPEXPAR and MNAzyme for the olfactory marker protein detection.

Fig. 1: Schematic illustration of the principle of the Dual targets driven SPEXPAR assisted MNAzyme (D-S-M) fluorescent biosensor for olfactory marker protein (OMP) detection. A.

Structure-guided discovery of novel dUTPase inhibitors with anti- activity by computational design.

The zoonosis caused by is increasing seriously. But commonly used antibiotic drugs often lead to resistance. dUTPase (dUTPase) plays a key role in the proliferation of , and was regarded as a potent drug target.

Preparation, process optimisation, stability and bacteriostatic assessment of composite nanoemulsion containing corosolic acid.

Corosolic acid (CA), a pentacyclic triterpenoid, exhibits remarkably low hydrophilicity, restricting its application in aqueous systems. To enhance its hydrophilicity, we optimised nanoemulsion preparation conditions, resulting in a stable corosolic acid nanoemulsion system. By screening the oil phase, surfactant, and cosurfactant, along with investigating the mass ratio of surfactant and cosurfactant and the preparation temperature, we achieved an optimal corosolic acid nanoemulsion.

[Teaching reform and practice of the postgraduate course "Biocatalysis and Enzyme Engineering" under the "dual-drive and dual-guide" model].

Value shaping and innovation capability improvement are two important goals of postgraduate course teaching. Biocatalysis and Enzyme Engineering is a core course for postgraduates majoring in bioengineering. Our teaching team established a "dual-drive and dual-guide" teaching model, that is, "double drive" (value-driven + innovation-driven) as the traction, this model integrated professional quality with industry needs, engineering ethics, and scientist spirit, combined theoretical teaching with research frontiers, industrial cases, and engineering practice, and incorporated thematic lectures, group peer evaluation, and review papers into course assessment.

A B7-H3-targeted CD28 bispecific antibody enhances the activity of anti-PD1 and CD3 T-cell engager immunotherapies.

T-cell activation is a multistep process requiring T-cell receptor engagement by peptide-major histocompatibility complexes (Signal 1) coupled with CD28-mediated costimulation (Signal 2). Tumors typically lack expression of CD28 ligands, so tumor-specific Signal 1 (e.g.

Highly Enantioselective Synthesis of Polycyclic Dihydroisoquinolinones via NHC-Catalyzed [4 + 2] Annulations.

The NHC-catalyzed enantioselective [4 + 2] annulation of 9-fluorene-1-carbaldenydes with cyclic imines was successfully developed. A series of optically enriched polycyclic dihydroisoquinolinones were synthesized in moderate to excellent yields with good to excellent enantioselectivities. In addition, this efficient method could also be amenable to the synthesis of spirocyclic compounds by using isatin-derived ketimines as the electrophiles.

Strain-Release-Driven Electrochemical Skeletal Rearrangement of Non-Biased Alkyl Cyclopropanes/Butanes.

Capitalizing the inherent strain energy within molecules, strain-release-driven reactions have been widely employed in organic synthesis. Small cycloalkanes like cyclopropanes and cyclobutanes, with their moderate ring strain, typically require dense functionalization to induce bias or distal activation of (hetero) aromatic rings via single-electron oxidation for relieving the tension. In this study, we present a pioneering direct activation of alkyl cyclopropanes/butanes through electrochemical oxidation.

Sappanone A enhances hepatocyte proliferation in lipopolysaccharide-induced acute liver injury in mice by promoting injured hepatocyte apoptosis and regulating macrophage polarization.

Objectives: Lipopolysaccharide (LPS), also known as endotoxin, is the main toxic component of the cell wall of gram negative bacteria, which is released after bacterial death and widely exists in the living environment. Human exposure to endotoxin may cause sepsis. The occurrence of septic liver injury is a prominent factor contributing to mortality in patients with sepsis.

Transcriptome sequencing reveals non-coding RNAs respond to porcine reproductive and respiratory syndrome virus and co-infection in Kele piglets.

Co-infection with porcine reproductive and respiratory syndrome virus (PRRSV) and (HPS) has severely restricted the healthy development of pig breeding. Exploring disease resistance of non-coding RNAs in pigs co-infected with PRRSV and HPS is therefore critical to complement and elucidate the molecular mechanisms of disease resistance in Kele piglets and to innovate the use of local pig germplasm resources in China. RNA-seq of lungs from Kele piglets with single-infection of PRRSV or HPS and co-infection of both pathogens was performed.

wraps around and synergistically escapes from Neutrophil extracellular traps.

Background: NETs, a unique neutrophil immune mechanism, are vital in defending against microbial invasions. Understanding the mechanisms of co-infection by and , which often leads to higher mortality and poorer prognosis, is crucial for studying infection progression.

Methods: In our study, we established a mouse model of subcutaneous infection to characterize the inflammation induced by co-infection.

Algae promotes the biogenic oxidation of Mn(II) by accelerated extracellular superoxide production.

Microbial manganese (Mn) oxidation, predominantly occurs within the anaerobic-aerobic interfaces, plays an important role in environmental pollution remediation. The anaerobic-aerobic transition zones, notably riparian and lakeside zones, are hotspots for algae-bacteria interactions. Here, we adopted a Mn(II)-oxidizing bacterium Pseudomonas sp.