Methylation-dependent Tissue Factor Suppression Contributes to the Reduced Malignancy of IDH1-mutant Gliomas.

Purpose: Gliomas with mutations (IDH1) are less aggressive than IDH1 wild-type (IDH1) gliomas and have global genomic hypermethylation. Yet it is unclear how specific hypermethylation events contribute to the IDH1 phenotype. Previously, we showed that the gene encoding the procoagulant tissue factor (TF), , is among the most hypermethylated and downregulated genes in IDH1 gliomas, correlating with greatly reduced thrombosis in patients with IDH1 glioma.