Publications by authors named "Qasim Shah"

The growing interest in plant-derived compounds and synthesis of metallopolymer nanocomposites (MPNCs) especially silver chitosan nanocomposites (AgCS-NCs) emerges as a useful platform to encapsulate and deliver plant-based anticancer drugs. This work presents the synthesis of AgCS-NCs by using Moringa oleifera aqueous leaf extract (MOAE) and the effect of concentration of MOAE on physicochemical properties of AgCS-NCs followed by its anticancer effect on MCF-7 cell line. The results of UV-visible spectroscopy (UV-Vis) and Scanning electron microscopy (SEM) showed successful formation of AgCS-NCs.

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Article Synopsis
  • The CRISPR-Cas9 method is a groundbreaking tool for editing genes and has changed how scientists can modify DNA.
  • Researchers are exploring how changes in DNA and RNA can affect human diseases, especially through something called epigenetics.
  • New improvements in CRISPR technology are helping scientists better understand and treat diseases by making precise changes to DNA and controlling gene behavior.
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The rapid growth of the Internet of Things (IoT) and its integration into various industries has made it extremely challenging to guarantee IoT systems' dependability and quality, including scalability, dynamicity, and integration with existing IoT frameworks. However, the essential principles, approaches, and advantages of model-driven IoT testing indicate a promising strategy for overcoming these. This paper proposes a metamodeling-based interoperability and integration testing approach for IoT systems that automates the creation of test cases and the assessment of system performance by utilizing formal models to reflect the behavior and interactions of IoT systems.

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P2X7 receptor (P2X7R) has a key role in different pathological conditions, importantly overexpressed and activated in cancers. We explored the structure activity relationship (SAR) of three novel pyrazines, quinoline-carboxamide and oxadiazole series. Their selective inhibitory potency in Ca mobilization assay using h-P2X7R-MCF-7 cells improved with phenyl ring substitutions (-OCF, -CF, and -CH) in carboxamide and oxadiazole derivatives, respectively.

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Sustainable development objectives heavily promote the advancement of cleaner production technologies to reduce emissions and conserve the average world temperature. For the years 1990-2020, the USA, China, Japan, Russia, Germany, and Australia are studied by using the panel fully modified ordinary least square (FMOLS). The results show that clean fuels and technologies and a consumer price index are helpful to reduce greenhouse gas emissions from food system which reduce environmental degradation.

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Series of sulfonamide-substituted amide (-), benzamide (-), and 1,3-disubstituted thiourea (-) derivatives were synthesized from a common precursor, i.e., substituted benzoyl chlorides.

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L (ML) is locally used as an herbal contraceptive. We aim to assess the toxicity profile and validate the antifertility effects of its leaves in male rats. Adult male Sprague Dawley rats ( = 10 animals/group) were divided into four groups.

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Climate change policy has several potential risks. The purpose of this study is to investigate the impact of green technology development, green energy consumption, energy efficiency, foreign direct investment, economic growth, and trade (imports and exports) on greenhouse gas (GHG) emissions in South Asia from 1981 to 2018. We employed Breusch Pagan LM, bias-corrected scaled LM, and Pesaran CD as part of a series of techniques that can assist in resolving the problem of cross-sectional dependence.

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P2Y receptor (P2YR) antagonists represent potential drugs for treating cancer, pain, neurodegeneration, asthma, diabetes, colitis and other disorders. However, there are few chemical classes of known competitive antagonists. We recently explored the structure activity relationship (SAR) of 2H-chromene derivatives as P2YR antagonists of moderate affinity.

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High affinity phenyl-piperidine P2YR antagonist (PPTN) was modified with piperidine bridging moieties to probe receptor affinity and hydrophobicity. Various 2-azanorbornane, nortropane, isonortropane, isoquinuclidine, and ring-opened cyclopentylamino derivatives preserved human P2YR affinity (fluorescence binding assay), and their pharmacophoric overlay was compared. Enantiomeric 2-azabicyclo[2.

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Graph neural networks have been shown to achieve excellent performance for several crucial tasks in particle physics, such as charged particle tracking, jet tagging, and clustering. An important domain for the application of these networks is the FGPA-based first layer of real-time data filtering at the CERN Large Hadron Collider, which has strict latency and resource constraints. We discuss how to design distance-weighted graph networks that can be executed with a latency of less than one μs on an FPGA.

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This study evaluated the antifertility activity of methanolic extract of Chenopodium ambrosioides leaf on male rats. During the experiment, different doses of extract (0, 50, 100 and 150 mg/kg) were orally administered to rats for 28 days. Analysis of sperm parameters revealed a dose-dependent decrease in sperm motility, viability and daily sperm production (DSP).

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Article Synopsis
  • Hypertension is a significant health issue in Pakistan, but there's limited recent data on its prevalence, with the last national survey being over 20 years old.
  • The study aimed to determine the overall prevalence of hypertension in the Pakistani population using data from various research studies published between 1990 and 2017.
  • The results indicated a pooled prevalence of 26.34%, with higher rates in urban areas and an increase in prevalence over the decades, highlighting a concerning trend in hypertension among adults in Pakistan.
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