Food Safety Concerns in Pakistan: Monitoring of Antimicrobial-Resistant Bacteria and Residue Contamination in Commercially Available Fish and Poultry Meat Samples.

Food safety is a critical issue in the 21st century due to antibiotic-resistant bacteria causing harmful foodborne diseases. This comprehensive study meticulously examined the presence of bacterial isolates, quinolone residue, and antimicrobial resistance genes in samples of broiler and fish meat. Forty samples were collected from various locations in the Faisalabad metropolis.

Water Quality and Kidney Health in Farming Communities.

Since the turn of the century, there has been an increase in the frequency of chronic interstitial nephritis in agricultural communities. This is particularly evident in young farm workers from equatorial regions, where the prevalence of chronic kidney disease cannot be explained by classical risk determinants or exposure to heat stress alone. Potentially causal agents have included organic and inorganic drinking water contaminants.

Nutritional and antioxidative characterization, antimicrobial and sensorial stability of flaxseed powder supplemented mutton patties.

Oxidative stress and microbial growth deteriorate food quality and cause safety risks. Therefore, the present study was investigated to explore the nutritional, sensorial, anti-oxidative and anti-microbial attributes of flaxseed powder (FP) supplemented at 2-8 % (i.e.

Uncovering Antiviral Potential of Cistus ladanifer Extracts Against HSV-1 and SARS-CoV-2 by In Vitro and In Silico Analysis.

Infectious diseases remain a major global health concern. Cistus ladanifer, a plant commonly employed in Moroccan traditional medicine, has been identified as a potential antiviral candidate. This study aimed to evaluate the antiviral activity of C.

The complexities in the differential diagnosis of restless legs syndrome (Willis-Ekbom disease).

Introduction: We present a literature review on the clinical conundrums surrounding the differential diagnosis of restless legs syndrome (RLS, Willis-Ekbom disease), as well as conditions that can mimic RLS. An extensive literature search showed that secondary causes of RLS ranged from commonly recognized causes, such as iron deficiency anemia, to less widely noted causes, such as rheumatoid disorders and hypothyroidism. There is a controversial association with Parkinson's disease, essential tremor, and RLS, whereby RLS is proposed as a prodromal feature.

Advancements in Structural Basis of Covalent Inhibitors Targeting SARS-CoV-2 Essential Proteins.

Covalent inhibitors play a pivotal role in the development of pharmaceutical therapies, as they form stable, irreversible bonds with target biomolecules, leading to prolonged therapeutic effects and enhanced efficacy. Since covalent inhibitors first appeared in the late 1800s, the field has become innovative rapidly, and covalent inhibitors now account for around 30% of all marketed therapeutics. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the pandemic of Coronavirus Disease 2019 (COVID-19).

Inclusive AI for radiology: Optimising ChatGPT-4 with advanced prompt engineering.

This letter responds to the article "Encouragement vs. liability: How prompt engineering influences ChatGPT-4's radiology exam performance," offering additional perspectives on optimising ChatGPT-4 for Radiology applications. While the study highlights the significance of prompt engineering, we suggest that addressing additional key challenges such as age-related diagnostic needs, socio-economic diversity, data security, and liability concerns is essential for responsible AI integration.

Test, track, treat using wearable sensors for management of Parkinson's disease: 12‑month prospective observational United Arab Emirates study using Parkinson's Kinetograph (EmPark-PKG Study).

Parkinson's disease (PD) is a progressive neurodegenerative disorder marked by both motor and non-motor symptoms that necessitate ongoing clinical evaluation and medication adjustments. Home-based wearable sensor monitoring offers a detailed and continuous record of patient symptoms, potentially enhancing disease management. The EmPark-PKG study aims to evaluate the effectiveness of the Parkinson's KinetoGraph (PKG), a wearable sensor device, in monitoring and tracking the progression of motor symptoms over 12 months in Emirati and non-Emirati PD patients.

FeS-based nanocomposites: A promising approach for sustainable environmental remediation - Focus on adsorption and photocatalysis - A review.

Population expansion, industrialization, urban development, and climate changes increased the water crisis in terms of drinking water availability. Among the various nanomaterials for nanoremediation towards water treatment, FeS-based nanocomposites have emerged as promising candidates in the adsorptive and photocatalytic removal of contaminants. This paper, therefore, evaluates the potential of FeS-based nanocomposites for environmental applications, more specifically the combined use of adsorption and photocatalysis.

Effect of thermal and non-thermal processing on Technofunctional, nutritional, safety and sensorial attributes of potato powder.

Potato is a highly nutritious staple food however, it also contains some antinutrients like alkaloids, phytates, tannins, oxalates as well as pesticide residues. Therefore, this study was conducted to reduce the loads of antinutrients and pesticides in potato powder (PP) using thermal and non-thermal processing techniques. Nutritional analysis revealed that the raw PP contained significantly ( < 0.

SLNP-based CDK4- targeted nanotherapy against glioblastoma.

Introduction: Glioblastoma is a grade IV solid brain tumor and has a 15-month survival rate even after treatment. Glioblastoma development is heavily influenced by retinoblastoma protein (pRB) pathway changes. The blood-brain barrier, drug resistance, and severe toxicity of Temozolamide are key obstacles in treating glioblastoma.

Hydride-Induced Reconstruction of Pd Electrode Surfaces: A Combined Computational and Experimental Study.

Designing electrocatalysts with optimal activity and selectivity relies on a thorough understanding of the surface structure under reaction conditions. In this study, experimental and computational approaches are combined to elucidate reconstruction processes on low-index Pd surfaces during H-insertion following proton electroreduction. While electrochemical scanning tunneling microscopy clearly reveals pronounced surface roughening and morphological changes on Pd(111), Pd(110), and Pd(100) surfaces during cyclic voltammetry, a complementary analysis using inductively coupled plasma mass spectrometry excludes Pd dissolution as the primary cause of the observed restructuring.

NEONATAL HYDROMETROCOLPOS: CLINICAL PRESENTATION AND THERAPEUTIC APPROACH.

Hydrometrocolpos (HMC) is a rare pediatric condition characterized by significant enlargement of the uterus and vagina due to the accumulation of fluid, generally caused by a blockage in the lower vagina. This disorder typically presents in newborns with the retention of normal genital tract secretions. The following case report highlights the clinical features, diagnostic process, and treatment of HMC in a newborn.

Toxic Dye Degradation Employing Phoenix dactylifera Seed Extract for the Green Synthesis of Silver Nanoparticles: Characterization and Application.

This research highlights the facile green synthesis of silver nanoparticles (AgNPs) using Phoenix dactylifera seed extracts and its photocatalytic application for the degradation of toxic dyes. The AgNPs synthesis was confirmed by the appearance of its representative absorption peak at 416 nm in UV-visible absorption spectroscopy. Moreover, the reduction of silver ions to Ag was justified through Fourier transform infrared (FTIR) spectroscopy.

Prescribing Patterns of Antibiotics in Pediatric Wards of Secondary Care Centers: A Retrospective Study Based on WHO AWaRe Classification.

Antimicrobial resistance (AMR) poses a significant threat to global public health, with substantial mortality rates attributed to AMR-related infections. Pediatric populations face heightened vulnerability due to prevalent antimicrobial misuse. This study aimed at addressing the significant threat of antimicrobial resistance (AMR) and its associated mortality rates.

Flexible Electromagnetic Sensor with Inkjet-Printed Silver Nanoparticles on PET Substrate for Chemical and Biomedical Applications.

For this article, a low-cost, compact, and flexible inkjet-printed electromagnetic sensor was investigated for its chemical and biomedical applications. The investigated sensor design was used to estimate variations in the concentration of chemicals (ethanol and methanol) and biochemicals (hydrocortisone-a chemical derivative of cortisol, a biomarker of stress and cardiovascular effects). The proposed design's sensitivity was further improved by carefully choosing the frequency range (0.

The Investigation of Structural, Optical and Thermal Properties of Nickel Doped CeO Integrated PVC Nanocomposite.

PVC nanocomposite (NC) films with cubic CeO and Ni-doped CeO (NDC) have been prepared using a conventional solution-casting technique. The prepared films were characterized with FT-IR spectrometer, X-ray diffraction (XRD), and scanning electron microscopy (SEM). The optical and thermal properties of the films were evaluated using a UV-visible spectrophotometer and TGA/DSC.

An evaluation of the preprints produced at the beginning of the 2022 mpox public health emergency.

Background: Preprints are scientific articles that have not undergone the peer-review process. They allow the latest evidence to be rapidly shared, however it is unclear whether they can be confidently used for decision-making during a public health emergency. This study aimed to compare the data and quality of preprints released during the first four months of the 2022 mpox outbreak to their published versions.

Sparkling Synergy: Enhancing Hydrogen Evolution with a Mesoporous CoP/FeP Interface.

The reaction kinetics is predominantly determined by the surface and interface engineering of electrocatalysts. Herein, we demonstrate the growth of cobalt monophosphide and iron monophosphide (CoP/FeP) with an effective solid interface. The surface of CoP/FeP is mesoporous, which is obtained by phosphidizing mesoporous CoFeO.

Facile Synthesis of -(4-Bromo-3-methylphenyl)pyrazine-2-carboxamide Derivatives, Their Antibacterial Activities against Clinically Isolated XDR , Alkaline Phosphatase Inhibitor Activities, and Docking Studies.

The emergence of extensively drug-resistant Typhi (XDR-) poses a grave public health threat due to its resistance to fluoroquinolones and third-generation cephalosporins. This resistance significantly complicates treatment options, underscoring the urgent need for new therapeutic strategies. In this study, we synthesized pyrazine carboxamides (-) in good yields through the Suzuki reaction.

Addressing the Ethnicity Gap in Catechol O-Methyl Transferase Inhibitor Trials in Parkinson's Disease: A Review of Available Global Data.

Catechol-O-methyltransferase inhibitors (COMT-Is) have significantly improved the quality of life and symptom management for those at advanced stages of Parkinson's Disease (PD). Given that PD is one of the fastest-growing neurodegenerative diseases worldwide, there is a need to establish a clear framework for the systematic distribution of COMT-Is, considering inter-individual and intra-individual variations in patient response. One major barrier to this is the underrepresentation of ethnic minority participants in clinical trials investigating COMT-Is.

Vestibular Neurostimulation for Parkinson's Disease: A Novel Device-Aided Non-Invasive Therapeutic Option.

Dopaminergic replacement therapy remains the mainstay of symptomatic treatment for Parkinson's disease (PD), but many unmet needs and gaps remain. Device-based treatments or device-aided non-oral therapies are typically used in the advanced stages of PD, ranging from stereotactic deep brain stimulation to levodopa or apomorphine infusion therapies. But there are concerns associated with these late-stage therapies due to a number of procedural, hardware, or long-term treatment-related side effects of these treatments, and their limited nonmotor benefit in PD.