Publications by authors named "Q-Z Wang"

Imprinting abnormalities pose a significant challenge in applications involving embryonic stem cells, induced pluripotent stem cells, and animal cloning, with no universal correction method owing to their complexity and stochastic nature. In this study, we targeted these defects at their source-embryos from same-sex parents-aiming to establish a stable, maintainable imprinting pattern de novo in mammalian cells. Using bi-paternal mouse embryos, which exhibit severe imprinting defects and are typically non-viable, we introduced frameshift mutations, gene deletions, and regulatory edits at 20 key imprinted loci, ultimately achieving the development of fully adult animals, albeit with a relatively low survival rate.

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Purpose To develop and evaluate a deep learning-based prognostic model for predicting survival in locoregionally- advanced nasopharyngeal carcinoma (LA-NPC) using serial MRI before and after induction chemotherapy (IC). Materials and Methods This multicenter retrospective study included 1039 LA-NPC patients (779 male, 260 female, mean age 44 [standard deviation: 11]) diagnosed between April 2009 and December 2015. A radiomics- clinical prognostic model (Model RC) was developed using pre-and post-IC MRI and other clinical factors using graph convolutional neural networks (GCN).

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Rationale And Objectives: To propose a novel MRI-based hyper-fused radiomic approach to predict pathologic complete response (pCR) to neoadjuvant therapy (NAT) in breast cancer (BC).

Materials And Methods: Pretreatment dynamic contrast-enhanced (DCE) MRI and ultra-multi-b-value (UMB) diffusion-weighted imaging (DWI) data were acquired in BC patients who received NAT followed by surgery at two centers. Hyper-fused radiomic features (RFs) and conventional RFs were extracted from DCE-MRI or UMB-DWI.

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Background: Whether it is effective and safe to extend the time window of intravenous thrombolysis up to 24 hours after the last known well is unknown. We aimed to determine the efficacy and safety of tenecteplase in Chinese patients with acute ischemic stroke due to large/medium vessel occlusion within an extended time window.

Methods: Patients with ischemic stroke presenting 4.

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DS-Cav1, SC-TM, and DS2 are distinct designer pre-fusion F proteins (pre-F) of respiratory syncytial virus (RSV) developed for vaccines. However, their immunogenicity has not been directly compared. In this study, we generated three recombinant vaccines using the chimpanzee adenovirus vector AdC68 to express DS-Cav1, SC-TM, and DS2.

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Background: Risk profile of recurrence may influence the effect of antiplatelet therapy. This study aimed to evaluate the efficacy and safety of clopidogrel-aspirin initiated within 72 hours after symptom onset for acute mild stroke or high-risk transient ischemic attack stratified by risk profile.

Methods: This is a secondary post hoc analysis of the INSPIRES (Intensive Statin and Antiplatelet Therapy for Acute High-risk Intracranial or Extracranial Atherosclerosis) randomized clinical trial that enrolled patients 35 to 80 years old with acute mild ischemic stroke or high-risk transient ischemic attack between 2018 and 2022.

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Background: Type A aortic dissection (TAAD) is a life-threatening condition characterized by complex pathophysiology, in which macrophages play a critical but not yet fully understood role. This study focused on the role of endothelial cells with elevated expression of ACKR1 (atypical chemokine receptor 1) and their interaction with proinflammatory macrophages in TAAD development.

Methods: Single-cell transcriptomic analysis of human aortic tissues was used to identify cellular heterogeneity in TAAD.

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Rationale And Objectives: To construct and validate a clinical-radiomics model based on radiomics features extracted from two-stage multimodal ultrasound and clinicopathologic information for early predicting pathologic complete response (pCR) to neoadjuvant chemotherapy (NAC) in breast cancer patients treated with NAC.

Materials And Methods: Consecutive women with biopsy-proven breast cancer undergoing multimodal US pretreatment and after two cycles of NAC and followed by surgery between January 2014 and November 2023 were retrospectively collected for clinical-radiomics model construction (n = 274) and retrospective test (n = 134). The predictive performance of it was further tested in a subsequent prospective internal test set recruited between January 2024 to July 2024 (n = 76).

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Background Gallium 68 (Ga) pentixafor has emerged as a potential C-X-C chemokine receptor type 4 (CXCR4)-targeted radiotracer for neuroendocrine tumor, yet its application in Cushing disease remains uncertain. Purpose To assess the diagnostic accuracy and value of Ga-pentixafor PET/MRI in localizing adrenocorticotropic hormone (ACTH)-secreting pituitary tumors in Cushing disease. Materials and Methods A prospective single-center study was conducted from March 2023 to February 2024 in participants with Cushing disease scheduled for surgical pituitary tumor resection.

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Background: Imlunestrant is a next-generation, brain-penetrant, oral selective estrogen-receptor (ER) degrader that delivers continuous ER inhibition, even in cancers with mutations in the gene encoding ERα ().

Methods: In a phase 3, open-label trial, we enrolled patients with ER-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer that recurred or progressed during or after aromatase inhibitor therapy, administered alone or with a cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor. Patients were assigned in a 1:1:1 ratio to receive imlunestrant, standard endocrine monotherapy, or imlunestrant-abemaciclib.

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  • The study aimed to evaluate how tourniquet usage impacts surgical time, muscle injury, and pain after ACL reconstruction.
  • Researchers conducted a systematic review of randomized controlled trials, extracting data on various factors such as operative time and postoperative pain across seven studies with 471 participants.
  • Findings indicated that tourniquet use reduced surgery duration but was linked to increased muscle injury markers (higher CPK levels) and greater postoperative pain and blood loss.
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Background: The effect of embolization of the middle meningeal artery in patients with subacute or chronic subdural hematoma is uncertain.

Methods: We performed a multicenter, open-label, randomized trial in China, involving patients with symptomatic nonacute subdural hematoma with mass effect. Patients were assigned to undergo burr-hole drainage or receive nonsurgical treatment at the surgeon's discretion, and patients in each group were then randomly assigned, in a 1:1 ratio, to undergo middle meningeal artery embolization with liquid embolic material or to receive usual care.

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  • A study was conducted to find out the best systolic blood pressure targets for patients over 50 with type 2 diabetes and high cardiovascular risk, comparing intensive treatment (target <120 mm Hg) to standard treatment (target <140 mm Hg) over 5 years.
  • Out of 12,821 patients, the intensive treatment group had a lower average systolic blood pressure after one year (121.6 mm Hg) compared to the standard group (133.2 mm Hg), resulting in significantly fewer major cardiovascular events.
  • Despite the lower overall events in the intensive group, there were more cases of symptomatic hypotension and hyperkalemia, but the rates of serious adverse events were similar in both groups.
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Phytophthora pathogens secrete numerous apoplastic effectors to manipulate host immunity. Herein, we identified a polysaccharide lyase 1 protein, PsPL1, which acts as an essential virulence factor of P. sojae infection in soybean.

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In deep-space optical communication systems, precise pointing and aiming of the laser beam is essential to ensure the stability of the laser link. In this paper, an adaptive compound control system based on adaptive feedforward and Proportional-Integral-Differentiation (PID) feedback is proposed. The feedforward controller is stabilized using Youla-Kucera (YK) parameterization.

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Background: We aim to assess the efficacy of rapid local ischemic postconditioning (RL-IPostC) following successful reperfusion in patients with acute ischemic stroke with anterior circulation large vessel occlusion who underwent endovascular thrombectomy.

Methods: We conducted an ambidirectional cohort study with 78 prospectively enrolled patients with RL-IPostC and endovascular thrombectomy and 129 retrospectively enrolled patients with endovascular thrombectomy. The RL-IPostC procedure involved 5 cycles of 15-s balloon inflation and deflation in the ipsilateral internal carotid artery.

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Two-dimensional (2D) ion crystals may represent a promising path to scale up qubit numbers for ion trap quantum information processing. However, to realize universal quantum computing in this system, individually addressed high-fidelity two-qubit entangling gates still remain challenging due to the inevitable micromotion of ions in a 2D crystal as well as the technical difficulty in 2D addressing. Here we demonstrate two-qubit entangling gates between any ion pairs in a 2D crystal of four ions.

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  • Basal cells (BCs) maintain the tracheal epithelium's integrity, and mitochondrial pyruvate carriers (MPCs) are crucial for determining BC fate.
  • Inhibiting MPCs allows BCs from both mice and humans to expand long-term, with genetic changes in mice showing issues in cell differentiation and regeneration.
  • The study suggests that manipulating pyruvate-citrate metabolism could correct abnormal BC behavior in lung diseases, including chronic obstructive lung disease (COPD).
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  • Zorifertinib is an experimental cancer drug that targets mutations in the EGFR gene and has shown effectiveness in patients with lung cancer that has spread to the brain.
  • A phase 3 trial compared zorifertinib to standard treatments and found that it significantly extended the time patients lived without the disease worsening (progression-free survival).
  • Results indicate that zorifertinib may be a better first-line treatment option for non-small cell lung cancer due to its ability to improve survival and manage side effects effectively.
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  • Scientists created a computer program called ReportGuidedNet that helps find brain problems in MRI scans by using information from radiology reports.
  • They tested this program on thousands of brain scans from different hospitals and compared it to another program called PlainNet that didn’t use report info.
  • ReportGuidedNet did a much better job at diagnosing brain conditions and understanding where to look on the scans, making it more reliable and easier to explain its findings.
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  • H3K27ac is an important marker for active enhancers and is linked to metabolic dysfunction-associated steatotic liver disease (MASLD), which is not fully understood yet.
  • A study found that H3K27ac levels and related gene activity are significantly increased in rats with MASLD due to a high-fat diet, identifying the gene TDO2 as a key player in abnormal fat accumulation.
  • The researchers developed a nanoparticle-based treatment to inhibit TDO2, which effectively reduces liver fat and metabolic issues, suggesting that targeting the H3K27ac-TDO2-NF-κB pathway could lead to new treatments for MASLD.
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Glucagon-like peptide-1 (GLP-1) analogs are important therapeutics for type 2 diabetes and obesity. Ecnoglutide (XW003) is a novel, long-acting GLP-1 analog. We conducted a Phase 2, randomized, double-blind, placebo-controlled study enrolling 145 adults with T2DM.

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Background: Remote ischemic preconditioning (RIPC) has 2 time windows for organ protection: acute and delayed. Previous studies have mainly focused on the organoprotective effects of acute RIPC. We aimed to determine whether delayed RIPC can reduce the occurrence of acute kidney injury (AKI) and postoperative complications in patients undergoing cardiac surgery.

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  • In June 2019, a patient in Inner Mongolia developed severe symptoms after a tick bite, leading to the discovery of a new virus named Wetland virus (WELV) through advanced genetic testing.
  • Active surveillance identified 17 cases of WELV infection across multiple regions in China, with patients exhibiting a range of nonspecific symptoms and laboratory abnormalities.
  • WELV was isolated from various ticks and animals, and studies showed that it can cause serious illness in mice, indicating a potential tick vector for the virus.
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