Proteolysis-targeting influenza vaccine strains induce broad-spectrum immunity and in vivo protection.

Generating effective live vaccines from intact viruses remains challenging owing to considerations of safety and immunogenicity. Approaches that can be applied in a systematic manner are needed. Here we created a library of live attenuated influenza vaccines by using diverse cellular E3 ubiquitin ligases to generate proteolysis-targeting (PROTAR) influenza A viruses.

Precise deletion, replacement and inversion of large DNA fragments in plants using dual prime editing.

Precise manipulation of genome structural variations holds great potential for plant trait improvement and biological research. Here we present a genome-editing approach, dual prime editing (DualPE), that efficiently facilitates precise deletion, replacement and inversion of large DNA fragments in plants. In our experiments, DualPE enabled the production of specific genomic deletions ranging from ~500 bp to 2 Mb in wheat protoplasts and plants.

Novel MRI-based Hyper-Fused Radiomics for Predicting Pathologic Complete Response to Neoadjuvant Therapy in Breast Cancer.

Rationale And Objectives: To propose a novel MRI-based hyper-fused radiomic approach to predict pathologic complete response (pCR) to neoadjuvant therapy (NAT) in breast cancer (BC).

Materials And Methods: Pretreatment dynamic contrast-enhanced (DCE) MRI and ultra-multi-b-value (UMB) diffusion-weighted imaging (DWI) data were acquired in BC patients who received NAT followed by surgery at two centers. Hyper-fused radiomic features (RFs) and conventional RFs were extracted from DCE-MRI or UMB-DWI.

Radiomic Features at Contrast-Enhanced CT Predict Virus-Driven Liver Fibrosis: A Multi-Institutional Study.

Introduction: Liver fibrosis is a major cause of morbidity and mortality among in patients with chronic hepatitis. Radiomics, particularly of the spleen, may improve diagnostic accuracy and treatment strategies. External validations are necessary to ensure reliability and generalizability.

Design of Pentanary Mixed-Chalcogenides AgInSiSSe ( = 1, 2) Based on the Bucket Effect: Local Structural Difference and High-Performance Nonlinear-Optical Properties Realized by Partial Congener Substitution.

Noncentrosymmetric chalcogenides are promising candidates for infrared nonlinear-optical (NLO) crystals, and exploring high-performance ones is a hot topic and challengeable. Herein, the combination of AgQ, InQ, and SiQ (Q = S, Se) units with different S/Se ratios resulted in the discovery of the tetrahedral chalcogenides AgInSiSSe () and AgInSiSSe (). They both crystallize in the monoclinic space group with different local structures.

Arthroscopic Surgery Combined With Platelet-Rich Plasma Does Not Significantly Improve Pain, Function, Complications, and Retear Rate Compared With Arthroscopic Surgery Alone for Full-Thickness Rotator Cuff Tears: A Systematic Review and Meta-analysis.

Purpose: To evaluate the effectiveness and safety of arthroscopic surgery combined with platelet-rich plasma (PRP) compared with arthroscopic surgery alone in the treatment of patients with full-thickness rotator cuff tears.

Methods: The Cochrane Library, PubMed, Embase, Scopus, EBSCO, Web of Science, China National Knowledge Infrastructure, and Wanfang Database were systematically searched from inception to November 2023. Subject words combined with free words were used to collect randomized controlled trials focusing on arthroscopic surgery combined with PRP in the treatment of full-thickness rotator cuff tears.

Pentanary Oxythiogermanates BaMGeOS (M = Ca, Zn) Featuring [GeOS] Trimers and {[MGeOS]} Chains: Structural Chemistry and Physical Properties.

Oxychalcogenides are increasingly attracting wide attention because they contain multiple anions that may combine the advantages of oxides and chalcogenides. In this work, two new pentanary oxythiogermanates, BaMGeOS [M = Ca (), Zn ()], were synthesized by a high-temperature solid-state reaction. They crystallize in the orthorhombic space group , and their structures contain isolated [GeOS] units constructed by one [GeOS] and two [GeOS] tetrahedra that link with M ions to build the {[MGeOS]} chain, representing a new type of oxythiogermanate.

Polysubstitution Induced Centrosymmetric-to-Noncentrosymmetric Structural Transformation and Nonlinear-Optical Behavior: The Case of NaAgGaSe.

Obtaining compounds with large nonlinear-optical (NLO) coefficients and wide band gaps is challenging due to their competitive requirements for chemical bonds. Herein, the first member with mixed cations on the A site in the A-M-Q or A-Ag-M-Q (A = alkali metal; M = Ga, In; Q = S, Se, Te) family, NaAgGaSe (NAGSe), was obtained by a solid-state reaction. Its structure features [GaSe] tetrahedra built three-dimensional {[GaSe]} network, with Na and Na/Ag cations located at the octahedral cavities.

Rational Design of Novel Promising Infrared Nonlinear Optical Materials: Structural Chemistry and Balanced Performances.

ConspectusSecond-order nonlinear optical (NLO) materials are currently a hot topic in modern solid-state chemistry and optics because they can produce coherent light by frequency conversion. Noncentrosymmetric (NCS) structure is not only the prerequisite for NLO materials but also a challengeable issue because materials tend to be centrosymmetric (CS) in terms of thermodynamical stability. Among NLO materials, an excellent infrared (IR) candidate should simultaneously meet several strict key conditions including a large NLO coefficient, high laser-induced damage threshold (LIDT), phase-matchable (PM) behavior, and so on.

NaREPSe (RE = Y, Sm, Gd-Dy): Quaternary Rare-Earth Selenophosphates with Unique 3D {[REPSe]} Framework Built by RESe and PSe Motifs and Multiple Properties.

Rare-earth (RE) chalcophosphates have been widely studied because of their abundant structures. Here, five new RE selenophosphates, NaREPSe (RE = Y, Sm, Gd-Dy), were synthesized by a facile RE oxide-boron-selenium solid-state route. They crystallize in the triclinic 1̅ space group, featuring three-dimensional (3D) structures constructed by RESe and PSe motifs, different from common 2D RE chalcophosphates A-RE-P-Q (A = alkali metal; Q = S, Se) system.

ABCQ: A New Family for the Design of Infrared Nonlinear Optical Materials by Coupling Octahedra and Tetrahedra Units.

Large second-harmonic generation (SHG) response and broad band gap are two important and competitive parameters. It is difficult to balance them out in one material. In this work, by coupling alkali earth metal (AEM) octahedra with large highest occupied molecular orbital (HOMO)-lowest unoccupied molecular orbital (LUMO) gap and nonlinear optical (NLO)-active tetrahedra units, nine noncentrosymmetric (NCS) compounds, belonging to a new quaternary chalcogenide family ABCQ with unique windmill-like [MgMQ] (M = Al, Ga; Q = S, Se) units constructed by alternated [MgQ] octahedra and [MQ] tetrahedra, are rationally designed and fabricated.

Discovery of chalcogenides structures and compositions using mixed fluxes.

Advancements in many modern technologies rely on the continuous need for materials discovery. However, the design of synthesis routes leading to new and targeted solid-state materials requires understanding of reactivity patterns. Advances in synthesis science are necessary to increase efficiency and accelerate materials discovery.

Synthesis of mesoporous-structured MIL-68(Al)/MCM-41-NH for methyl orange adsorption: Optimization and Selectivity.

Here, we report a novel amino-modified mesoporous-structured aluminum-based metal-organic framework adsorbent, MIL-68(Al)/MCM-41-NH, for dye sewage treatment. The introduction of molecular sieves overcomes the inherent defects of microporous MOFs in contaminant transfer and provides more active sites to enhance adsorption efficiency. Compared with using organic amino ligands directly, this strategy is ten times cheaper.

Evidence for Nonlinear Gluon Effects in QCD and Their Mass Number Dependence at STAR.

The STAR Collaboration reports measurements of back-to-back azimuthal correlations of di-π^{0}s produced at forward pseudorapidities (2.6<η<4.0) in p+p, p+Al, and p+Au collisions at a center-of-mass energy of 200 GeV.

A Retrospective Cohort Study of Factors Influencing Lymph Node Metastasis in Patients With Early Gastric Papillary Adenocarcinoma.

Introduction: High risk of lymph node metastasis (LNM) in gastric papillary adenocarcinoma causes endoscopists to worry about the suitability of endoscopic resection for early gastric papillary adenocarcinoma (EPAC). We compared risk factors and attempted to establish a scoring system to stratify LNM risk in patients with EPAC.

Methods: A retrospective analysis was performed on 2,513 patients with early gastric carcinoma (EGC) who underwent radical resection in 4 tertiary hospitals in China.

Establishment and Implementation of Potential Fluid Therapy Balance Strategies for ICU Sepsis Patients Based on Reinforcement Learning.

Objective: Fluid therapy for sepsis patients has always been a problem that puzzles clinicians, that is, knowing when patients need fluid infusion and when they need negative fluid balance. Different clinicians may have different judgment criteria and make different decisions. Recently, studies have suggested that different fluid treatment strategies can cause different clinical outcomes.

Rare examples of hybrid chalcogenoarsenate(III) incorporating trivalent vanadium complexes.

A series of new hybrid vanadium chalcogenoarsenates(III) [V(en)AsS] (1, en = ethylenediamine), [V(dap)AsSe] (2, dap = 1,2-diaminopropane), [V(teta)AsQ] {Q = S (3) and Se (4), teta = triethylene-tetramine}, and [VIII2(en)(μ-O)][AsSe] (5) were solvothermally prepared and structurally characterized. The trigonal-pyramidal [AsQ] anions in 1-4 act as η-AsQ chelating ligands to the unsaturated trivalent vanadium complex cations [V(en/dap)]/[V(teta)], resulting in neutral molecules. 5 consists of a discrete saddle-like selenidoarsenate [AsSe] anion built up from corner-sharing [AsSe] trigonal pyramids and the dinuclear trivalent vanadium complex cation [VIII2(en)(μ-O)] constructed through two [V(en)] units bridged one μ-O group.

Sodium-Glucose Cotransporter-2 Inhibitors in Patients With Heart Failure : A Systematic Review and Meta-analysis.

Background: Randomized controlled trials established the cardiac protection of sodium-glucose cotransporter-2 (SGLT2) inhibitors among adults with type 2 diabetes. New evidence suggests that these results could extend to people without diabetes.

Purpose: To evaluate the effect of SGLT2 inhibitors in patients with heart failure, regardless of the presence of type 2 diabetes.

Development and Validation of Prognostic Models to Estimate the Risk of Overt Hepatic Encephalopathy After TIPS Creation: A Multicenter Study.

Introduction: Overt hepatic encephalopathy (HE) is a major complication of transjugular intrahepatic portosystemic shunt (TIPS). This study aimed to develop and validate prognostic models to identify patients at different risks of overt HE within 3 months after TIPS.

Methods: Two cohorts of patients with cirrhosis undergoing TIPS insertion were retrospectively included.

Clinical impact of craniopharyngioma classification based on location origin: a multicenter retrospective study.

Background: An assessment of the clinical impact for craniopharyngiomas (CPs) classification based on origin location has not been reported. The aim of this study was to determine the clinical impact of the site of tumor origin in primary CPs.

Methods: Patients from six national institutions who had undergone resection for primary CP were enrolled.

Dynamic compensation control strategy of DC bus voltage based on residual generator.

Aiming at the problem of bus voltage control in DC microgrid, a dynamic compensation control strategy based on a residual generator is designed to complete the voltage compensation of DC-DC converter. Firstly, based on the DC microgrid system architecture, the bus voltage fluctuations are analyzed theoretically, and then the DC-DC converter state-space mathematical models of the DC microgrid system are established to obtain the input-output relationship of the control system. Based on the theory of double coprime decomposition and Youla parameterization stable controller, the proposed control architecture based on the residual generator is obtained, and the output value generated by the current disturbance is compensated in reverse by applying model matching theory.

Potential Benefits of Underdilation of 8-mm Covered Stent in Transjugular Intrahepatic Portosystemic Shunt Creation.

Introduction: Hepatic encephalopathy (HE) is a major complication of transjugular intrahepatic portosystemic shunt (TIPS) creation. This study was aimed to determine whether underdilated TIPS with 8-mm polytetrafluoroethylene-covered stents could reduce the risk of HE and liver damage yet maintain clinical and hemodynamic efficacy.

Methods: This retrospective case-controlled study included 134 patients treated with TIPS from March 2017 to November 2019.

One-Dimensional Vanadium(III) Chalcogenidostannates Incorporating [V(tepa)] Complexes as Bridging Groups.

Two new one-dimensional (1D) vanadium(III) chalcogenidostannates, [Htepa][V(tepa)(μ-SnQ)] [Q = S (), Se (); tepa = tetraethylenepentamine], were achieved by solvothermal methods, which offer the first examples of organic hybrid polymeric chalcogenidostannates incorporating [V(tepa)] complexes as bridging groups. Both and feature the 1D sinusoidal chains of [V(tepa)(μ-SnQ)] containing two types of novel bridging modes of the [μ-SnQ] anion. Their magnetic, photocurrent response, and optical properties are also studied.

Utility of Natural Sitting Lateral Radiograph in the Diagnosis of Segmental Instability for Patients with Degenerative Lumbar Spondylolisthesis.

Background: Segmental instability in patients with degenerative lumbar spondylolisthesis is an indication for surgical intervention. The most common method to evaluate segmental mobility is lumbar standing flexion-extension radiographs. Meanwhile, other simple radiographs, such as standing upright radiograph, a supine sagittal magnetic resonance imaging (MRI) or supine lateral radiograph, or a slump or natural sitting lateral radiograph, have been reported to diagnose segmental instability.

Bilateral Bundle Branch Area Pacing to Achieve Physiological Conduction System Activation.

Background: Left bundle branch pacing (LBBP) is a technique for conduction system pacing, but it often results in right bundle branch block morphology on the ECG. This study was designed to assess simultaneous pacing of the left and right bundle branch areas to achieve more synchronous ventricular activation.

Methods: In symptomatic bradycardia patients, the distal electrode of a bipolar pacing lead was placed at the left bundle branch area via a transventricular-septal approach.