Polydatin suppresses VEGF-induced angiogenesis through binding with VEGF and inhibiting its receptor signaling.

Polydatin, also called piceid, is a stilbenoid glucoside of a resveratrol derivative. It derives mainly from the root and rhizome of Polygonum cuspidatum Sieb. et Zucc.

Evaluating the susceptibility of mitochondrial DNA germline mutations in Chinese cancer patients.

It has been suggested that impairment of mitochondrial oxidative phosphorylation (OXPHOS) is a common character in cancer cells, urging attention to variation on mitochondrial DNA (mtDNA) that encodes 13 units of the OXPHOS. However, most of mtDNA somatic mutations in cancer were suggested to result from the relaxed functional constrains and thus the byproducts of tumorigenesis. MtDNA germline mutations present not only in the cancer tissue but also in the normal tissue.

Magnetic resonance image-guided transcatheter closure of atrial septal defects.

Background: Recent developments in cardiac MRI have extended the potential spectrum of diagnostic and interventional applications. The purpose of this study was to test the ability of MRI to perform transcatheter closures of secundum type atrial septal defects (ASD) and to assess ASD size and changes in right cardiac chamber volumes in the same investigation.

Methods And Results: In 7 domestic swine (body weight, 38+/-13 kg), an ASD (Q(p):Q(s)=1.