Publications by authors named "Q Zhuge"
Introduction: T cell Antigen Coupler (TAC) T cells harness all signaling subunits of endogenous T cell receptor (TCR) to trigger T-cell activation and tumor cell lysis, with minimal release of cytokines. Some of the major obstacles to cellular immunotherapy in solid tumors include inefficient cell infiltration into tumors, lack of prolonged cellular persistence, and therapy-associated toxicity.
Methods: To boost the cytotoxic potential of TAC-T cells against solid tumors, we generated a novel NECTIN-4-targeted TAC-T variant, NECTIN-4 TAC28-T, which integrated the co-stimulatory CD28 cytoplasmic region, and compared the anti-tumor activities between NECTIN-4 TAC-T cells and NECTIN-4 TAC28-T cells in vitro and vivo.
Background: To identify biomarkers and develop an inflammatory score based on proper integration to improve risk prediction of delayed cerebral ischemia (DCI) and poor outcome in patients with aneurysmal subarachnoid hemorrhage (aSAH). We also further explore the mediation and interaction of DCI within the chain of events using the four-way effect decomposition.
Methods: Machine learning algorithms are used for biomarker selection and constructed the inflammatory score.
Digital radio-over-fiber (D-RoF) quantizes the wireless waveform to improve the noise tolerance in fronthaul links. Unlike conventional data transmission, the quantization bits exhibit different weights, offering a new strategy to protect the high-weight bits. By introducing a dual-drive MZM (DD-MZM)-based optical transmitter, the interaction between frequency chirp and chromatic dispersion (CD) results in eye closure/open.
View Article and Find Full Text PDFIntracerebral hemorrhage (ICH) is a devastating form of stroke associated with significant morbidity and mortality. Microglia are intracranial innate immune cell that play critical roles in Intracerebral hemorrhage through direct or indirect means. Vesicle transport is a fundamental mechanism of intercellular communication.
View Article and Find Full Text PDFArticle Synopsis
- Glioblastoma is a common and aggressive brain cancer, and researchers discovered that cancer cells can be transformed into neuron-like cells using specific proteins, NEUROG2 and SOXC.
- The study utilized various techniques, including ChIP-seq and RNA-seq, to explore how NEUROG2 and SOXC factors interact in this reprogramming process, revealing that SOXC factors actually function as transcriptional repressors rather than activators.
- The findings suggest that manipulating pathways involving RhoA and its effectors can mimic the effects of SOXC factors, providing potential new approaches for reprogramming glioblastoma cells into neurons.