Utilization of wall-breaking sludge for improving soil structure in abandoned mine land.

Promoting soil structure is considered an essential prerequisite for abandoned mine land restoration. Sewage sludge (SS) has the potential to improve soil structure. However, traditional SS application to improve soil structure requires a lot of SS, potentially exacerbating heavy metal (HM) contamination.

TRIAGE: an R package for regulatory gene analysis.

Regulatory genes are critical determinants of cellular responses in development and disease, but standard RNA sequencing (RNA-seq) analysis workflows, such as differential expression analysis, have significant limitations in revealing the regulatory basis of cell identity and function. To address this challenge, we present the TRIAGE R package, a toolkit specifically designed to analyze regulatory elements in both bulk and single-cell RNA-seq datasets. The package is built upon TRIAGE methods, which leverage consortium-level H3K27me3 data to enrich for cell-type-specific regulatory regions.

A mitochondria-interfering nanocomplex cooperates with photodynamic therapy to boost antitumor immunity.

Immunotherapeutics against triple-negative breast cancer (TNBC) hold great promise. In this work, we provide a combination therapy for simultaneous increasing tumor immunogenicity and down-regulating programmed cell death ligand 1 (PD-L1) to boost antitumor immunity in TNBC. We prepare bis (diethyldithiocarbamate)-copper/indocyanine green nanoparticles (CuET/ICG NPs) simply in aqueous with one-pot method.

Smith-Magenis syndrome with Dandy-Walker malformation in a 2-year-old girl: A case report.

Smith-Magenis syndrome (SMS) and Dandy-Walker malformation (DWM) are uncommon genetic conditions with nonspecific clinical features, which makes reaching a definitive diagnosis challenging. We describe here, a 2-year-old girl who was diagnosed with SMS at the age of 12 months due to delayed growth and development. The child presented to hospital with acute heart failure and respiratory failure.

Influence of the Transducer-Mounting Method on the Radiation Performance of Acoustic Sources Used in Monopole Acoustic Logging While Drilling.

Transducers used in acoustic logging while drilling (ALWD) must be mounted on a drill collar, and their radiation performance is dependent on the employed mounting method. Herein, the complex transmitting voltage response of a while-drilling (WD) monopole acoustic source was calculated through finite-element harmonic-response analysis. Subsequently, the acoustic pressure waveform radiated by the source driven by a half-sine excitation voltage signal was calculated using the complex transmitting voltage response.