Confining Spirocyclic Fluorescein in an Asymmetric Solid-State Nanochannel: A Simple and Versatile Design Concept for Fabricating Integrated Nanofluidic Diodes with Adjustable Surface Chemistry.

Using small molecules to integrate multifunctional surfaces within a nanopore is an effective way to endow smart responsibilities of nanofluidic diodes. However, the complex synthesis of the small molecules hinders their further application in achieving multifunctional surfaces. Here, a simple and versatile design concept is reported for fabricating bioinspired integrated nanofluidic diodes with adjustable surface chemistry by confining a spirocyclic fluorescein derivative, 6-aminofluorescein (6-AF), within an asymmetric track-etched nanopore.

Causal Associations Between Chronic Obstructive Pulmonary Disease and Common Comorbidities: Evidence from Comprehensive Genetic Methods.

Background: Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory lung disease with high morbidity and mortality worldwide. Observational studies have shown correlations between common extrapulmonary comorbidities and COPD, but the existence of correlations does not necessarily prove a causal association. Therefore, causal relationships between diseases need to be explored by means of causal inference methods.

Lactate Dehydrogenase Indicates Development From Fulminant Myocarditis to Chronic Persistent Myocarditis: A Multicenter Retrospective Cohort Study in China.

Background: Fulminant myocarditis (FM) is a critical manifestation of myocarditis. However, the clinical features and risk factors associated with its adverse outcomes are not fully understood. Given the high mortality and potential for long-term complications, it is crucial to identify factors that could predict the progression of FM to chronic persistent myocarditis.

Sulfite-Induced Release and Oxidation of Cr(III) in Reduced Chromite Ore Processing Residue under Visible Light: The Critical Role of Fe(IV) Intermediates.

Reduced chromite ore processing residue (rCOPR) is vulnerable to the surrounding conditions in environments, which can induce the release and oxidation of Cr(III). This work found the synergistic effect of light and sulfite on destroying rCOPR stability, causing the significant release of Cr(VI), which was 4∼7 times higher than that under single factor action. In CrFe(OH)/sulfite/light system, Cr(VI) release rate could reach 11.

Studies on the Efficient Extraction of Ovotransferrin and the Effect of Heating Treatment on Its Structure and Activity.

Ovotransferrin (OVT) is very rich in nutritional value and possesses a variety of biological activities. However, there is a lack of suitable OVT extraction methods that are simple and suitable for large-scale production. For this reason, this study explored a new method of ovalbumin OVT extraction based on mesophilic treatment.