Phosphorylation-dependent VaMYB4a regulates cold stress in grapevine by inhibiting VaPIF3 and activating VaCBF4.

Cold stress severely impacts the quality and yield of grapevine (Vitis L.). In this study, we extend our previous work to elucidate the role and regulatory mechanisms of Vitis amurensis MYB transcription factor 4a (VaMYB4a) in grapevine's response to cold stress.

NK cell exhaustion in Wilson's disease revealed by single-cell RNA sequencing predicts the prognosis of cholecystitis.

Metabolic abnormalities associated with liver disease have a significant impact on the risk and prognosis of cholecystitis. However, the underlying mechanism remains to be elucidated. Here, we investigated this issue using Wilson's disease (WD) as a model, which is a genetic disorder characterized by impaired mitochondrial function and copper metabolism.

Hydraulic performance of a pre-aerated stilling basin: Experimental study.

Spillway chutes are critical in dam flood control, particularly in high dams where high water heads and large discharge in narrow canyons amplify the demand for safe discharging. For large unit discharges in spillways, aeration protection is essential to prevent cavitation erosion, but challenges arise from air duct choking in the traditional spillway and nonaerated regions in the stepped spillway. This paper introduces a novel spillway called the pre-aerated stilling basin spillway (PSBS).

The Financial Toxicity Experience of Patients with Colorectal Cancer During Chemotherapy: A Qualitative Study.

Background: This study aimed to explore the experience of financial toxicity in patients with colorectal cancer during chemotherapy and to inform the development of targeted interventions.

Methods: A descriptive qualitative research method was used to conduct semi-structured interviews with a purposive sample of 15 patients with colorectal cancer undergoing chemotherapy who attended the Department of Medical Oncology of the First Affiliated Hospital of Anhui Medical University from March to June 2024, and the data were organized and analyzed using the Nvivo 11.0 qualitative data analysis software and the thematic analysis method.

University STEM Students' Perceived Challenges During the COVID-19 Pandemic.

University students faced unprecedented challenges and stressors during the COVID-19 pandemic. STEM students experienced unique challenges because many had traditional lectures and hands-on learning in laboratories or field settings. This qualitative study aimed to explore STEM university students' experiences and difficulties perceived during the pandemic.