Gestational weight gain (GWG) is critical for maternal and neonatal health, but excessive GWG can lead to complications such as gestational diabetes, hypertension, and increased obesity risk later in life. Minoritized and immigrant women often face higher risks of excessive GWG. This cross-sectional study assessed Central American women's beliefs and concerns about GWG, the receipt of advice from healthcare providers, and sources of information for healthy weight management during pregnancy.
View Article and Find Full Text PDFThe application of sand-clay mixtures is diverse in contemporary engineering practices, with particular emphasis on their shear strength characteristics. This study focused on the estimation of the shear strength of sand-clay mixtures using the artificial neural network (ANN) and low-field nuclear magnetic resonance (NMR) spectroscopy. In this study, NMR tests and triaxial compression tests were carried out on 160 artificial sand-clay mixtures with different mineralogical compositions, water contents, and dry densities in the laboratory to obtain the T spectra and shear strength indices, respectively.
View Article and Find Full Text PDFDelivering protein drugs to the central nervous system (CNS) is challenging due to the blood-brain and blood-spinal cord barrier. Here we show that neutrophils, which naturally migrate through these barriers to inflamed CNS sites and release neutrophil extracellular traps (NETs), can be leveraged for therapeutic delivery. Tannic acid nanoparticles tethered with anti-Ly6G antibody and interferon-β (aLy6G-IFNβ@TLP) are constructed for targeted neutrophil delivery.
View Article and Find Full Text PDFToxicol Appl Pharmacol
December 2024
The elevated risk of cardiovascular disease (CVD) associated with inflammatory rheumatic diseases has long been recognized. Patients with established rheumatoid arthritis (RA) have a higher mortality rate compared to the general population due to abnormal platelet activation. Thymidine phosphorylase (TYMP) plays a crucial role in platelet activation and thrombosis, following bridging the link between RA and CVD.
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