Comparison of cerebral technetium-99m-ethyl cysteinate dimer perfusion in patients with dementia with Lewy bodies and Parkinson's disease dementia.

Dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD) are closely related neurodegenerative conditions within the Lewy body spectrum. The relationship between DLB and PDD remains debated, with ongoing discussion about whether they are distinct diseases or different manifestations of the same disorder. This study aimed to identify differences in cerebral perfusion patterns between DLB and PDD patients.

Dissecting the Predictors of Cyber-Aggression Through an Explainable Machine Learning Model.

The general aggression model (GAM) suggests that cyber-aggression stems from individual characteristics and situational contexts. Previous studies have focused on limited factors using linear models, leading to oversimplified predictions. This study used the light gradient boosting machine (LightGBM) to identify and rank the importance of various risk and protective factors in cyber-aggression.

A novel phenotype imputation method with copula model.

Background: Jointly analyzing multiple phenotype/traits may increase power in genetic association studies by aggregating weak genetic effects. The chance that at least one phenotype is missing increases exponentially as the number of phenotype increases especially for a real dataset. It is a common practice to discard individuals with missing phenotype or phenotype with a large proportion of missing values.

The splicing factor SF3B1 is essential for proper alternative splicing and zygotic genome activation in early porcine embryos.

Alternative splicing (AS) is a pivotal posttranscriptional regulatory mechanism that is involved in embryonic development. However, the roles of AS in specific developmental events, especially the zygotic genome activation (ZGA) of porcine early embryos, remain unclear. In this study, we demonstrated that alternative splicing events (ASEs) were most prevalent in mammalian embryos during ZGA and that skipped exons were the predominant splicing pattern.