THE USAGE AND REPORTING OF DENTAL PATIENT-REPORTED OUTCOMES AMONG SYSTEMATIC REVIEWS IN ORTHODONTICS: A METHODOLOGICAL STUDY.

Objective: To summarize and analyze the usage and reporting of dental patient-reported outcomes (dPROs) within systematic reviews (SRs) published in 5 leading orthodontic journals between 2015 and 2023.

Methods: A manual search was conducted to identify intervention (therapeutic or preventive) involved SRs published in selected journals between 2015 and 2023 from the official online archives. Two authors independently and in duplicate extracted the characteristics of each included SR, recording both the usage of dPROs in the Methods sections and the reporting of dPROs in the Results sections.

Natural Products Targeting Tau Protein Phosphorylation: A Promising Therapeutic Avenue for Alzheimer's Disease.

Alzheimer's disease is a progressive neurodegenerative disorder characterized by tau protein hyperphosphorylation and neurofibrillary tangle formation, which are central to its pathogenesis. This review focuses on the therapeutic potential of natural products in targeting tau phosphorylation, a key factor in Alzheimer's disease progression. It comprehensively summarizes current research on various natural compounds, including flavonoids, alkaloids, saponins, polysaccharides, phenols, phenylpropanoids, and terpenoids, highlighting their multitarget mechanisms, such as modulating kinases and phosphatases.

Multiomics analysis revealed the effects of polystyrene nanoplastics at different environmentally relevant concentrations on intestinal homeostasis.

Nanoplastics pollution is a global issue, with the digestive tract being one of the first affected organs, requiring further research on its impact on intestinal health. This study involved orally exposing mice to polystyrene nanoplastics (PS-NPs) at doses of 0.1, 0.

Microneedle hierarchical structure construction for promoting multi-stage wound healing.

As a new type of drug delivery system, microneedle have received extensive attention in wound healing due to their penetrability, painlessness, and high drug delivery efficiency. However, microneedle are often unable to penetrate the skin completely due to the limitations of the skin's mechanical properties, resulting in low drug delivery efficiency during wound repair. Therefore, it is particularly important to optimize the multi-level structural design of microneedles.

The potential effective components from Danlou tablet attenuates acute myocardial infarction by restoring ALOX12-mediated perturbed oxylipins.

Ethnopharmacological Relevance: Danlou Tablet (DLP) was developed from the "Gualou-Xiebai-Baijiu decoction", as documented in the "Synopsis of the Golden Chamber" by Dr. Zhongjing Zhang. It is widely used for clinical treatment of different degrees of coronary heart disease (CHD).