Publications by authors named "Q Razlighi"
Background: Different subtypes of Alzheimer's Disease (AD) are shown to have differential patterns of tau deposition on the cerebral cortex. However, for cognitively unimpaired elders the spatial specificity of tau deposition has not been fully investigated.
Objective: We aim to show that tau deposition in different brain regions is uniquely associated with performance in different cognitive domains.
The deposition of amyloid-β (Aβ) protein in the human brain is a hallmark of Alzheimer's disease and is related to cognitive decline. However, the relationship between early Aβ deposition and future cognitive impairment remains poorly understood, particularly concerning its spatial distribution and network-level effects. Here, we employed a cross-validated machine learning approach and investigated whether integrating subject-specific brain connectome information with Aβ burden measures improves predictive validity for subsequent cognitive decline.
View Article and Find Full Text PDFDiagnostic accuracy of phosphorylated tau217 in detecting Alzheimer's disease pathology among cognitively impaired and unimpaired: A systematic review and meta-analysis.
Alzheimers Dement
December 2024
Our review summarizes the diagnostic accuracy of plasma and cerebrospinal fluid (CSF) phosphorylated tau 217 (p-tau217) in detecting amyloid and tau pathology on positron emission tomography (PET). We systematically reviewed studies that reported the diagnostic accuracy of plasma and CSF p-tau217, searching MEDLINE/PubMed, Scopus, and Web of Science through August 2024. The accuracy of p-tau217 in predicting amyloid and tau pathology on PET was evaluated in 30 studies.
View Article and Find Full Text PDFArticle Synopsis
- Late-onset psychosis (LOP) is a complex and poorly understood condition that could stem from late-onset schizophrenia or Alzheimer's disease, making accurate diagnosis crucial for effective treatment.
- * This study used structural MRI data from 699 healthy individuals and 469 patients with schizophrenia or Alzheimer's to employ data-driven techniques, specifically K-means clustering, to differentiate between these conditions.
- * Findings indicated that structural differences, such as larger right putamen volumes in schizophrenia patients, could help in distinguishing between AD and SCZ, highlighting the need for better diagnostic tools for LOP.
Objective: To investigate whether the Negative BOLD Response (NBR) is more task-specific than the Positive BOLD Response (PBR) during cognitive tasks and to determine whether task-evoked activity reflects brain reconfigurations during different tasks better than functional connectivity.
Methods: Functional Magnetic Resonance Imaging (fMRI) data were collected from 214 participants under 50 years old (152 in Dataset 1 and 62 in Dataset 2) performing twelve cognitive tasks spanning vocabulary, speed of processing, fluid reasoning, and memory domains. Data analysis included subject-level and group-level analyses, focusing on comparing the spatial patterns and task specificity of NBR and PBR through similarity measures using Dice coefficients.