ARNT-dependent HIF-2α signaling protects cardiac microvascular barrier integrity and heart function post-myocardial infarction.

Myocardial infarction (MI) compromises the cardiac microvascular endothelial barrier, increasing leakage and inflammation. HIF2α, predominantly expressed in cardiac endothelial cells during ischemia, has an unclear role in barrier function during MI. Here, we show that inducible, adult endothelial-specific deletion of Hif2α in mice leads to increased mortality, cardiac leakage, inflammation, reduced heart function, and adverse remodeling after MI.

A near-infrared "turn-on" fluorescent probe for selective detection of copper(II) ions in aqueous media and its application in cell imaging.

Copper (II) is considered the third most essential trace element for life, following iron and zinc, and plays a vital role in various physiological and pathological processes. The fluorescent probe has become an important method for the detection of heavy metal ions. This investigation involved the development and synthesis of a near-infrared "turn-on" fluorescent probe, DCX-Cu, with a significant Stokes shift (156 nm), specifically to identify Cu compared other ions.

A Crystalline Polymer Cathode for Sodium-Organic Batteries.

Sodium-organic batteries (SOBs) are widely recognized as a rising star in large-scale energy storage technology because of their abundant resources, high energy density, and environmental friendliness. However, the poor cyclability and rate performance due to high solubility and poor conductivity with organic electrode materials limit their practical applications. Here, we constructed a new crystalline polymer poly(tetraaminobenzoquione) (PTABQ) featuring a layered structure with conjugated backbone and intermolecular hydrogen bonds.

Bioinformatics Analysis of the Expression and Prognostic Significance of Transcription Factor YY1 in Gastric Cancer.

Background: Emerging evidence indicates that the transcription factor Yin Yang 1 (YY1) plays a critical role in the carcinogenesis and progression of various human malignancies. YY1 is highly expressed in gastric cancer (GC), raising interest in its role in GC.

Aims: This study aims to analyze the role of YY1 in gastric cancer, investigate its effect on the tumor microenvironment, and assess its potential as a prognostic marker.

Maternal dietary flavonoid intake and child wheeze and asthma in the Conditions Affecting Neurocognitive Development and Learning in Early Childhood (CANDLE) cohort.

Background: Higher intakes of flavonoids have been associated with better lung function in adults. The aim of this study was to examine the associations between maternal prenatal intake of flavonoids and offspring asthma and wheeze.

Methods: We conducted a prospective study of Black (62.