Publications by authors named "Q Philippot"
Article Synopsis
- * A study examined 131 female patients with X-linked dominant incontinentia pigmenti (IP), finding that 36% produced autoantibodies against IFN-α and/or IFN-ω, significantly higher than age-matched controls.
- * The presence of these autoantibodies is linked to an abnormally small thymus and predisposes patients to life-threatening viral infections, while those without these autoantibodies do not face the same risk.
Article Synopsis
- Some babies with a specific mutation in the IL7R gene have a serious immune problem called SCID, where they lack a certain type of immune cells called T cells, but still have normal B and NK cells.
- In a study of 6 adults who have a similar genetic issue, they showed low levels of T cells but had relatively normal levels of other immune cells, indicating a more specific problem in T cell development.
- Even though their T cells didn’t grow well in the lab, the study hints that there might be another way T cells can develop that doesn’t depend solely on the IL-7 cytokine.
Severe defects in human IFNγ immunity predispose individuals to both Bacillus Calmette-Guérin disease and tuberculosis, whereas milder defects predispose only to tuberculosis. Here we report two adults with recurrent pulmonary tuberculosis who are homozygous for a private loss-of-function TNF variant. Neither has any other clinical phenotype and both mount normal clinical and biological inflammatory responses.
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- Human metapneumovirus (hMPV) is a major cause of respiratory infections, and this study focused on adult patients with hMPV-related lower respiratory tract infections to evaluate their clinical features and outcomes.
- A total of 208 patients were studied, with a median age of 74 years; most patients had coexisting health issues, and common symptoms included difficulty breathing and cough, while pneumonia was the most frequent diagnosis.
- The study found that 18% of patients had a complicated course requiring intensive care, with a notable increased risk in those with bacterial coinfections, suggesting the need for careful monitoring and potential early intervention in this population.