Deaminase-mediated chromatin accessibility profiling with single-allele resolution.

Binding of transcription factors (TFs) at gene regulatory elements controls cellular epigenetic state and gene expression. Current genome-wide chromatin profiling approaches have inherently limited resolution, complicating assessment of TF occupancy and co-occupancy, especially at individual alleles. In this work, we introduce Accessible Chromatin by Cytosine Editing Site Sequencing with ATAC-seq (ACCESS-ATAC), which harnesses a double-stranded DNA cytosine deaminase (Ddd) enzyme to stencil TF binding locations within accessible chromatin regions.

Assessment of potentially toxic and rare earth elements in surface soils of Dong Nai, Vietnam.

This study investigates the quantities of Rare Earth Elements (REEs) and Potentially Toxic Elements (PTEs) in Dong Nai Province's surface soils. Atomic Absorption Spectrometry (AAS) and Instrumental Neutron Activation Analysis (INAA) were used to determine element concentrations. To validate the concentration results, established reference materials (NIST 2711 and IAEA Soil-7) were used.

Description of the larva of Hämäläinen, 2003 (Odonata, Platycnemididae), with a key to the larvae of the subfamily Platycnemidinae from the Sino-Japanese and Oriental regions.

The final instar larva of the rare species Hämäläinen, 2003 is described and illustrated here for the first time, including a new distribution record from Vietnam. The larva of differs from that of congeneric species by distinct morphological features, including the presence of four setae on the palpal lobe of the labium, the presence of lateral spines on abdominal S5-9, and a long terminal filament on the caudal lamella. We also provide a key to species for the known larvae of the subfamily Platycnemidinae in the Sino-Japanese and Oriental regions.

Core-Shell Bottlebrush Polymers: Unmatched Delivery of Small Active Compounds Deep Into Tissues.

The chemical structure of a delivery nanovehicle plays a pivotal role in determining the efficiency of drug delivery within the body. Leveraging the unique architecture of bottlebrush (BB) polymers-characterized by variations in backbone length, grafting density, and self-assembly morphology-offers a novel approach to understanding the influence of structural properties on biological behavior. In this study, developed a drug delivery system based on core-shell BB polymers synthesized using a "grafting-from" strategy.

Description of the final stadium larva of Cryptophaea vietnamensis (van Tol & Rozendaal, 1995) (Odonata: Euphaeidae) from Vietnam.

The final stadium larva of the Cryptophaea vietnamensis (van Tol & Rozendaal, 1995) from Vietnam is described and illustrated based on specimens reared to adulthood. This is the first record of a larva of the genus Cryptophaea Hämäläinen, 2003. The larvae of C.