Publications by authors named "Q P Vo"
Induced pluripotent stem cell (iPSC)-derived biological pacemakers have emerged as an alternative to traditional electronic pacemakers for managing cardiac arrhythmias. While effective, electronic pacemakers face challenges such as device failure, lead complications, and surgical risks, particularly in children. iPSC-derived pacemakers offer a promising solution by mimicking the sinoatrial node's natural pacemaking function, providing a more physiological approach to rhythm control.
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- Sepsis leads to systemic immune issues and organ failure, often resulting in severe brain disability, with young females showing better recovery than males.
- Using a mouse model, researchers found that after experiencing sepsis, both male and female mice showed weight regain and reduced gut microbiome diversity, but males displayed more significant immune changes and brain inflammation.
- fMRI analysis highlighted that while both sexes experienced similar changes in certain brain areas, male mice had altered connectivity patterns suggesting a delayed recovery process compared to females, indicating a complex, sex-dependent response to sepsis.
This study aimed to evaluate the effects of nanoparticulate CaCO (NPCC) on the biological properties of calcium silicate-based cements (CSCs), including their cytotoxicity, in vitro osteogenic activity, and interactions with rat femur tissue. The average size of NPCC was 90.3±26.
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- Primary percutaneous coronary intervention (PCI) can cause microvascular embolism by dislodging atherosclerotic debris, but thrombus aspiration (TA) before stenting in STEMI patients has shown benefits like reduced mortality and improved cardiac function.
- A study involving 92 STEMI patients at Nguyen Tri Phuong Hospital revealed that those who underwent TA had better TIMI and TMP flow grades and higher ST-segment normalization rates, although major adverse cardiac events (MACEs) at 30 days and 12 months were similar between TA and non-TA groups.
- The findings suggest that while TA can improve myocardial perfusion metrics in STEMI patients, it does not increase the risk of adverse outcomes, highlighting its potential role in enhancing coronary care
1,4-Dihydronicotinamide derivatives, including 1-methyl-1,4-dihydronicotinamide (MNAH), are derivatives of the active center of nicotinamide coenzyme (NADH) and are therefore potent radical scavengers. MNAH serves as a useful model of NADH that allows for modeling studies to address the activity of this important biomolecule. In this work, MNAH activity was evaluated against typical free radicals using quantum chemical calculations in physiological environments, with a secondary aim of comparing activity against two physiologically relevant radicals of markedly different stability, HO˙, and HOO˙, to establish which of these is a better model for assessing antioxidant capacity in physiological environments.
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