Proapoptotic Effect and Molecular Docking Analysis of Curcumin-Resveratrol Hybrids in Colorectal Cancer Chemoprevention.

Different hybrids based on curcumin and resveratrol were previously synthesized and characterized by spectroscopic techniques. The most active molecules (, , , and ) were evaluated in vitro as an approach to determine the possible mechanism of action of the hybrids. The results indicated that the evaluated curcumin/resveratrol hybrids induce mitochondrial instability in SW620 and SW480 cells.

Collisionless Shocks Driven by Supersonic Plasma Flows with Self-Generated Magnetic Fields.

Collisionless shocks are ubiquitous in the Universe as a consequence of supersonic plasma flows sweeping through interstellar and intergalactic media. These shocks are the cause of many observed astrophysical phenomena, but details of shock structure and behavior remain controversial because of the lack of ways to study them experimentally. Laboratory experiments reported here, with astrophysically relevant plasma parameters, demonstrate for the first time the formation of a quasiperpendicular magnetized collisionless shock.