Clinical impact of circulating biomarkers in prediction of adverse cardiac events in patients with congenital heart disease. A systematic review.

Introduction: Patients with congenital heart disease (ConHD) are at increased risk for adverse cardiac events. Predicting long-term outcomes and guidance of patient management might benefit from a range of (new) biomarkers. This is a rapidly evolving field with potentially large consequences for clinical decision making.

[Medically unexplained somatic symptoms are not unexplainable, misunderstood or vague physical complaints].

Background: In the current literature and in clinical practice a very wide range of terms is used to describe medically unexplained somatic symptoms; this gives rise to a number of problems.

Aim: To propose an unambiguous multidisciplinary terminology which can solve a number of problems.

Method: A literature search was conducted using the database PiCarta and references in the literature found via that database.