Thrombolytic therapy for patients with acute ischemic stroke: systematic review and network meta-analysis of randomized trials.

Objective: To systematically compare the benefits and risks of all thrombolytic agents (tenecteplase, reteplase, and alteplase) at different doses for thrombolytic therapy in patients with acute ischemic stroke (AIS).

Background: Alteplase is the cornerstone treatment for AIS, but alternative thrombolytic agents are needed. The efficacy and safety of tenecteplase and reteplase, compared to alteplase, remain unclear, as does the optimal dosing for these treatments.

Suberosin attenuates rheumatoid arthritis by repolarizing macrophages and inhibiting synovitis via the JAK/STAT signaling pathway.

Background: Rheumatoid arthritis (RA) is a systemic disease that primarily manifests as chronic synovitis of the symmetric small joints. Despite the availability of various targeted drugs for RA, these treatments are limited by adverse reactions, warranting new treatment approaches. Suberosin (SBR), isolated from Plumbago zeylanica-a medicinal plant traditionally used to treat RA in Asia-possesses notable biological activities.

Imperatorin's Effect on Myocardial Infarction Based on Network Pharmacology and Molecular Docking.

Myocardial infarction (MI), a severe cardiovascular disease, is the result of insufficient blood supply to the myocardium. Despite the improvements of conventional therapies, new approaches are needed to improve the outcome post-MI. Imperatorin is a natural compound with multiple pharmacological properties and potential cardioprotective effects.

Comparative analysis of petal phytoconstituents reveals insights into the characteristics of an under-reported edible old rose variety native to Chongqing, China.

Chongqing Old Rose is an ancient edible rose variety native to Chongqing, China, but is under-reported. Further evidence is required to fully establish its potential benefits. The complete metabolic profiles were examined for comparative analysis between the Old Rose and three rose cultivars.

Hibernation Habitat Selection by the Threatened Chinese Softshell Turtle () in the Yellow River Wetlands of Northwest China: Implications for Conservation Management.

Hibernation is a crucial aspect of the life history of freshwater turtles inhabiting temperate regions. Therefore, understanding their hibernation habitat selection is essential for the targeted conservation of turtle species and their habitats. The Chinese softshell turtle (), a medium-sized freshwater turtle, is widely distributed in China; however, populations are rapidly declining, and threatened by habitat destruction, overfishing, and water pollution.