From Natural Product Derivative to Hexagonal Prism Supermolecule: Potent Biofilm Disintegration, Enhanced Foliar Affinity, and Effective Management of Tomato Bacterial Canker.

Clavibacter michiganensis (Cmm), designated as an A2 quarantine pest by the European and Mediterranean Plant Protection Organization (EPPO), incites bacterial canker of tomato, which presently eludes rapid and effective control methodologies. Dense biofilms formed by Cmm shield internal bacteria from host immune defenses and obstruct the ingress of agrochemicals. Even when agrochemicals disintegrate biofilms, splashing and bouncing during application disperse active ingredients away from target sites.

Study on molecular structural heterogeneity of tar-rich coal based on micro-FTIR.

The coal molecular structure in micro-areas plays a critical role in matrix thermal conduction and volatile generation during the pyrolysis of tar-rich coal. However, as a major maceral contributing to hydrocarbon generation, the molecular structures of different micro-areas in vitrinite show heterogeneity, which still lacks research. Micro-FTIR technology was used in this study to characterize the molecular structure in different micro-areas of tar-rich coal with varying tar yields.

Exploring Dynamics and Intermolecular Interactions in Binary Mixtures of Reline and DMSO: An Investigation Using Nuclear Magnetic Resonance and Infrared Spectroscopic Techniques.

Reline, which is composed of choline chloride and urea in a molar ratio of 1:2, is the first and most extensively studied deep eutectic solvent (DES). In certain applications, reline is blended with organic solvents, dimethyl sulfoxide (DMSO) in most cases, to gain improved properties. Therefore, it is crucial to have a profound understanding of the impact of DMSO on the dynamics and structures of the species in the binary mixtures.

NLRP6 overexpression improves nonalcoholic fatty liver disease by promoting lipid oxidation and decomposition in hepatocytes through the AMPK/CPT1A/PGC1A pathway.

Objectives: To investigate the regulatory role of nucleotide-bound oligomerized domain-like receptor containing pyrin-domain protein 6 (NLRP6) in liver lipid metabolism and non-alcoholic fatty liver disease (NAFLD).

Methods: Mouse models with high-fat diet (HFD) feeding for 16 weeks (=6) or with methionine choline-deficient diet (MCD) feeding for 8 weeks (=6) were examined for the development of NAFLD using HE and oil red O staining, and hepatic expressions of NLRP6 were detected with RT-qPCR, Western blotting, and immunohistochemical staining. Cultured human hepatocytes (LO2 cells) with adenovirus-mediated NLRP6 overexpression or knock-down were treated with palmitic acid (PA) in the presence or absence of compound C (an AMPK inhibitor), and the changes in cellular lipid metabolism were examined by measuring triglyceride, ATP and β-hydroxybutyrate levels and using oil red staining, RT-qPCR, and Western blotting.

3D printing fiber-tip integrated Fabry-Perot interferometers for ultrasensitive RI sensing with an enhanced Vernier effect.

An ultrasensitive refractive index (RI) sensing technology based on an enhanced Vernier effect is proposed, which integrates a polymer Fabry-Perot interferometer (FPI) with an open cavity FPI on the tip of a seven-core optical fiber. Interference spectra of the polymer FPI and the open cavity FPI shift to opposite directions as the ambient RI changes, thus leading to the enhanced Vernier effect. Investigations of RI sensitivity and temperature dependence of the proposed fiber sensors are carried out.