Design, synthesis and antitumour activity of pyrimidine derivatives as novel selective EGFR kinase inhibitors.

Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, often linked to overexpression or abnormal activation of the epidermal growth factor receptor (EGFR). The issue of developing resistance to third-generation EGFR kinase inhibitors, such as osimertinib, underscores the urgent need for new therapies to overcome this resistance. Our findings revealed that compound A8 exhibits 88.

ExerGeneDB: A physical exercise-regulated differential gene expression database.

Background: Exercise induces molecular changes that involve multiple organs and tissues. Moreover, these changes are modulated by various exercise parameters-such as intensity, frequency, mode, and duration-as well as by clinical features like gender, age, and body mass index (BMI), each eliciting distinct biological effects. To assist exercise researchers in understanding these changes from a comprehensive perspective that includes multiple organs, diverse exercise regimens, and a range of clinical features, we developed Exercise Regulated Genes Database (ExerGeneDB), a database of exercise-regulated differential genes.

In situ surface oxygen vacancy effect synergistic with internal polarization effect in BiFeO for photoelectrochemical detection of T4 DNA ligase.

Recently, the field of cathode photoelectrochemistry has advanced significantly, yet there remained a dearth of innovative approaches in signal transmission strategies. This paper introduced a novel concept where the dopamine (DA)-engineered surface vacancy (Ov) effect on BiFeO microspheres synergistically interacted with the intrinsic polarization of the material, leading to a significantly enhanced photocurrent when compared to that of BiO or FeO alone without a built-in electric field. Based on this finding, we proposed a PEC biosensor that leveraged the competitive binding reaction between single-base nucleotides and DA for photocurrent output, wherein the T4 DNA ligase-mediated ligation reaction governed the production of single-base nucleotides.

Stabilization of Alkyltin γ-Keggin Clusters by 2, 5-Dihydroxyterephthalate Ligands.

The Keggin clusters are one kind of the most representative molecular structures in the field of metal-oxo clusters. Although the different types of Keggin clusters with various components were reported, the research about γ-Keggin isomer remains less developed. This is ascribed to the difficulty in obtaining the stable pure γ-Keggin cluster for the structural isomerization.