Publications by authors named "Q J M Huys"

Despite progress in smoking reduction in the past several decades, cigarette smoking remains a significant public health concern world-wide, with many smokers attempting but ultimately failing to maintain abstinence. However, little is known about how decision-making evolves in quitting smokers. Based on preregistered hypotheses and analysis plan ( https://osf.

View Article and Find Full Text PDF
Article Synopsis
  • The hippocampus helps combine different pieces of information to support decision-making in uncertain situations, known as hidden state inference.
  • This study found that the ventral hippocampus is crucial for mice to perform well in a task that requires them to infer hidden states when choosing between two options.
  • The research highlights how hippocampal activity influences the differentiation of contexts and dopamine signaling, which are important for making optimized decisions.
View Article and Find Full Text PDF
Article Synopsis
  • Current mental disorder classifications are based on convention and symptom clusters rather than biological mechanisms, leading to significant overlap and variability in diagnoses.
  • There is a need for a new diagnostic framework that incorporates neurobiology to enhance treatment options and help patients better understand their illnesses.
  • The ECNP New Frontiers Meeting 2024 aims to establish a roadmap for improved precision diagnostics by focusing on innovative technologies, the biology of mental illness, and translating this knowledge into effective treatment strategies.*
View Article and Find Full Text PDF

Attentional set shifting refers to the ease with which the focus of attention is directed and switched. Cognitive tasks, such as the widely used CANTAB IED, reveal great variation in set shifting ability in the general population, with notable impairments in those with psychiatric diagnoses. The attentional and learning processes underlying this cognitive ability and how they lead to the observed variation remain unknown.

View Article and Find Full Text PDF

Background: Mood disorders involve a complex interplay between multifaceted internal emotional states, and complex external inputs. Dynamical systems theory suggests that this interplay between aspects of moods and environmental stimuli may hence determine key psychopathological features of mood disorders, including the stability of mood states, the response to external inputs, how controllable mood states are, and what interventions are most likely to be effective. However, a comprehensive computational approach to all these aspects has not yet been undertaken.

View Article and Find Full Text PDF