A new species of Ctenocheles Kishinouye, 1926 (Decapoda, Axiidea, Ctenochelidae) from China.

A new species of ghost shrimp, Ctenocheles sinicus, is described based on specimens recently collected from Taiwan Strait, the East China Sea, at a depth of 50 m. The new species is characterized by: the dorsally unarmed rostrum attaining one-third the length of the eyestalks; the rounded suborbital angle of the carapace; maxillipeds 2 and 3 each with a short exopod; the merus and ischium of pereopod 1 being unarmed along the lower margin; the major cheliped with fingers twice as long as the palm; the ischium of pereopod 2 armed with prominent spiniform setae along the lower margin; and the rounded anterodistal angle of uropodal exopod. The morphological differences between the new species and other congeners are discussed and a key to the species of Ctenocheles Kishinouye, 1926 is provided.

E3 ubiquitin ligase HECW2: a promising target for tumour therapy.

Ubiquitination is a prevalent post-translational modification that plays a crucial role in a wide range of pathophysiological processes, including cell proliferation, apoptosis, autophagy, immune response, and DNA damage repair. Among the enzymes involved in ubiquitination, E3 ubiquitin ligases are particularly significant, serving as key regulators of numerous diseases, including tumours. This review focuses on HECW2 (HECT, C2, and WW domain-containing E3 ubiquitin protein ligase 2, also known as NEDL2), providing a comprehensive overview of its interactors and its pathological roles in tumorous cancer and other diseases.

Establishment of a Prognostic Model for Pancreatic Cancer Based on Hypoxia-Related Genes.

Objectives: Pancreatic cancer presents a formidable challenge with its aggressive nature and dismal prognosis, often hampered by elusive early symptoms. The tumor microenvironment (TME) emerges as a pivotal player in pancreatic cancer progression and treatment responses, characterized notably by hypoxia and immunosuppression. In this study, we aimed to identify hypoxia-related genes and develop a prognostic model for pancreatic cancer leveraging these genes.

Phosphate-to-alanine ratio and bilirubin-to-androsterone glucuronide ratio are the hub metabolites in upper gastrointestinal cancers: a Mendelian randomisation (MR) study.

Objective: Upper gastrointestinal (UGI) cancers, particularly esophageal cancer (EC) and gastric cancer (GC) represent a significant health burden with complex etiologies. Metabolic alterations are known to play a crucial role in cancer development and progression. Identifying key metabolic biomarkers may offer insights into the pathophysiology of UGI cancers and potential therapeutic targets.

Dual-Path Large Kernel Learning and Its Applications in Single-Image Super-Resolution.

To enhance the performance of super-resolution models, neural networks frequently employ module stacking. However, this approach inevitably results in an excessive proliferation of parameter counts and information redundancy, ultimately constraining the deployment of these models on mobile devices. To surmount this limitation, this study introduces the application of Dual-path Large Kernel Learning (DLKL) to the task of image super-resolution.