Publications by authors named "Q Hamid"
DNA damage underlies the progression of asthma toward a severe, steroid hyporesponsive phenotype. The accumulation of double-stranded DNA within the cytosol triggers the activation of cytosolic DNA-sensing pathways, notably the Stimulator of Interferon Genes (STING) pathway. However, the precise role of STING in driving steroid hyporesponsiveness remains elusive and warrants further investigation.
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- - The text discusses the urgent need to enhance the role of community pharmacists (CPs) in managing non-communicable diseases (NCDs) in the UAE, where these diseases are seen as a public health crisis.
- - A qualitative research study was conducted with 28 experts to gather insights, resulting in a roadmap focused on education, work environment, and policy improvements for CPs.
- - Key suggestions include establishing specialized programs for NCDs, fostering collaboration between healthcare disciplines, and increasing CP engagement in public health initiatives, requiring cooperation from various stakeholders.
Macrolide antibiotic azithromycin is widely used in clinical practice to treat respiratory tract infections and inflammatory diseases. However, its mechanism of action is not fully understood. Given the involvement of the CD27 pathway in the pathophysiology of various T-lymphocyte-mediated inflammatory, autoimmune, and lymphoproliferative diseases, we examined the impact of AZM on CD27 regulation and potential consequences on CD4+ and CD8+ T-cell phenotypes.
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- - Asthma is a chronic inflammatory disease affecting both children and adults, leading to irreversible changes in airway structure due to ongoing inflammation.
- - Common treatments like inhaled corticosteroids often face issues with steroid resistance, prompting the need for alternative therapies.
- - IL-5 has emerged as a key target for biological treatments, and the review discusses the role of IL-5 in asthma pathology and airway remodeling, highlighting available monoclonal antibodies like mepolizumab and reslizumab.
Article Synopsis
- The COVID-19 pandemic posed significant challenges for researchers and healthcare providers, with genetic factors like Single nucleotide variants (SNVs) in ACE2 and TMPRSS2 genes potentially influencing disease severity.
- The study examined gene variants in Emirati patients, finding that they lacked previously identified variants linked to COVID-19 severity, but identified a new variant associated with worse outcomes specifically in female patients.
- Results indicated that this new genetic variant affected gene transcription and was correlated with increased levels of certain cytokines and chemokines, highlighting the role of genetic factors in COVID-19 susceptibility and severity across different populations.