Publications by authors named "Q Fosse"
Background: The present study was designed to investigate the evolution and the impact of respiratory muscles function and limb muscles strength on weaning success in prolonged weaning of tracheotomized patients. The primary objective was to determine whether the change in respiratory muscles function and limb muscles strength over the time is or is not associated with weaning success.
Methods: Tracheotomized patients who were ventilator dependent upon admission at a weaning center were eligible.
Background: Improvements in oxygenation and lung mechanics with prone position (PP) in patients with acute respiratory distress syndrome (ARDS) are inconstant. The objectives of the study were (i) to identify baseline variables, including the recruitment-to-inflation ratio (R/I), associated with a positive response to PP in terms of oxygenation (improvement of the ratio of arterial oxygen partial pressure over the inspired oxygen fraction (PaO/FiO) ≥ 20 mmHg) and lung mechanics; (ii) to evaluate whether the response to the previous PP session is associated with the response to the next session.
Methods: In this prospective, observational, single-center study in patients who underwent PP for ARDS due to COVID-19, respiratory variables were assessed just before PP and at the end of the session.
Article Synopsis
- A novel ultrasound device (CUSdi) was tested in 49 mechanically ventilated patients to monitor diaphragm function, specifically measuring diaphragm excursion (EXdi) and contraction velocity (PCVdi).
- The results showed a strong correlation between measurements from CUSdi and standard ultrasound, indicating it can reliably assess diaphragm strength.
- The study found that an EXdi of less than 1.1 cm significantly predicts weaning failure, providing a critical cut-off value for clinicians to use during patient evaluations.
Introduction And Objectives: The human congenital central hypoventilation syndrome (CCHS) is caused by mutations in the PHOX2B (paired-like homeobox 2B) gene. Genetically engineered PHOX2B rodents exhibit defective development of the brainstem retrotrapezoid nucleus (RTN), a carbon dioxide sensitive structure that critically controls expiratory muscle recruitment. This has been linked to a blunted exercise ventilatory response.
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- Ventilator associated pneumonia (VAP) caused by wild-type AmpC-producing Enterobacterales is common in ICU patients, and the study explores the effectiveness of different antimicrobial therapies (AMT), specifically piperacillin ± tazobactam (PTZ) and third-generation cephalosporins (3GCs).
- In a study involving 274 ICU patients, no significant differences in treatment success at day 7 were found between the groups receiving PTZ, 3GCs, or other control treatments, with all groups showing success rates around 68-74%.
- However, patients treated with 3GCs had a higher likelihood of pneumonia recurrence by day 28 compared to those on PTZ