Four N ew Bisabolane-Type Sesquiterpenoids from Sanguisorba officinalis.

Sanguisorba officinalis L. (Di-Yu in Chinese) is a traditional herbal plant that belongs to the genus Sanguisorba (Rosaceae). Four new bisabolane-type sesquiterpenoids (1-4) and two known monoterpenoids (5 and 6) were isolated from the roots of S.

Unraveling the substrate-binding pocket: Endowing carbonyl reductase BaSDRX with intriguing inconsistent stereoselectivity towards similar structured β-Ketoesters.

Tailoring of carbonyl reductase with desired stereoselectivity for the asymmetric reduction of given β-ketoesters continues to pose a significant challenge. The reconstruction of substrate-binding pocket endowed carbonyl reductase BaSDRX with inconsistent stereoselectivity towards similar structured β-ketoesters. The variant F86C/E142A showed reversed stereoselectivity towards β-ketoesters with a larger substituent on the carbonyl side, giving antiPrelog alcohols with ee values varied from 52.

Development of a deep learning radiomics model combining lumbar CT, multi-sequence MRI, and clinical data to predict high-risk cage subsidence after lumbar fusion: a retrospective multicenter study.

Background: To develop and validate a model that integrates clinical data, deep learning radiomics, and radiomic features to predict high-risk patients for cage subsidence (CS) after lumbar fusion.

Methods: This study analyzed preoperative CT and MRI data from 305 patients undergoing lumbar fusion surgery from three centers. Using a deep learning model based on 3D vision transformations, the data were divided the dataset into training (n = 214), validation (n = 61), and test (n = 30) groups.

Coupling Photocatalytic Reduction and Biosynthesis Towards Sustainable CO Upcycling.

Upcycling carbon dioxide (CO) into long-chain compounds has attracted considerable attention with respect to mitigating environmental problems and obtaining value-added feedstocks, but remains a great challenge. Herein, we report a tandem photocatalysis-biosynthesis strategy for efficient CO reduction to energy-rich sucrose or α-farnesene. Firstly, photocatalytic reduction of CO to CH was optimized over the transitional metal doped ZnO (M-ZnO).

Insight into the role of antioxidant in microbial lignin degradation: Ascorbic acid as a fortifier of lignin-degrading enzymes.

Background: Microbial-driven lignin depolymerization has emerged as a promising approach for lignin degradation. However, this process is hindered by the limited activity of lignin-degrading enzymes. Antioxidants are crucial for maintaining redox homeostasis in living cells, which can impact the efficiency of enzymes.