Effects of melatonin on the pharmacokinetics and amino acid metabolism profile of vigabatrin in rats.

Objectives: Investigating the effect of melatonin (MLT) on the pharmacokinetics and related neurotransmitter and amino acid metabolism of vigabatrin (VGB) in epileptic rats in vivo.

Methods: High performance liquid chromatography was used to examine the pharmacokinetics and tissue distribution of VGB after intragastric administration dosing (50，100，200) mg/kg singly or in combination with melatonin (20 mg/kg) in rats. The single-compartment model of first-order elimination was fitted with the nonlinear mixed-effect model of first-order estimation.

Rational Design, Synthesis, and Biological Evaluation of Novel c-Met Degraders for Lung Cancer Therapy.

Cellular-mesenchymal epithelial transition factor (c-Met) is an attractive target for treating multiple cancers. Despite plentiful c-Met inhibitors have been developed, some issues, including the acquired drug resistance to c-Met inhibitors, have emerged to hamper their application in clinical treatment. Degradation of c-Met offers an opportunity to solve these issues.

Construction of a rodent neural network-skeletal muscle assembloid that simulate the postnatal development of spinal cord motor neuronal network.

Neuromuscular diseases usually manifest as abnormalities involving motor neurons, neuromuscular junctions, and skeletal muscle (SkM) in postnatal stage. Present in vitro models of neuromuscular interactions require a long time and lack neuroglia involvement. Our study aimed to construct rodent bioengineered spinal cord neural network-skeletal muscle (NN-SkM) assembloids to elucidate the interactions between spinal cord neural stem cells (SC-NSCs) and SkM cells and their biological effects on the development and maturation of postnatal spinal cord motor neural circuits.

A new in situ fracturing-enhanced oxidative remediation for various low-permeability phenanthrene-contaminated soils: Oxidation effectiveness and kinetics of potassium permanganate.

A new in situ fracturing-enhanced oxidative remediation approach was recommended in this study to achieve rapid and efficient remediation of low-permeability contaminated sites. The objective of this study was to evaluate the effects of permeability and potassium permanganate (KMnO) concentration on the oxidation effectiveness and kinetics of KMnO in phenanthrene (PHE)-contaminated soil through rigid-wall hydraulic conductivity tests and a series of laboratory experiments. The results indicate that for various low-permeability contaminated soils, there was a critical KMnO concentration to significantly reduce the remediation time and a critical Darcy velocity to meet remediation goals.

Automatic multimodal registration of cone-beam computed tomography and intraoral scans: a systematic review and meta-analysis.

Objectives: To evaluate recent advances in the automatic multimodal registration of cone-beam computed tomography (CBCT) and intraoral scans (IOS) and their clinical significance in dentistry.

Methods: A comprehensive literature search was conducted in October 2024 across the PubMed, Web of Science, and IEEE Xplore databases, including studies that were published in the past decade. The inclusion criteria were as follows: English-language studies, randomized and nonrandomized controlled trials, cohort studies, case-control studies, cross-sectional studies, and retrospective studies.